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1. Liu Shanshan, Lu Zhonghua. Serological characteristics and liver histopathological analysis of patients with chronic hepatitis B with normal ALT[J/OL].Journal of Clinical Hepatobiliary Diseases,1-6[2024-04-22].http://kns.cnki.net/kcms/detail/22.1108.R.20240327.1434.002.html.
Food and Health,2024,36(03):42-43.
3. Zhao Xiaoming, Jia Qin.Does it matter if aminotransferase is elevated[J].Family Medicine,2024,(02):58.)
In November 2018, Uncle Wang, who has retired 65 years old in Sichuan, participated in the physical examination of the unit, and the results of the physical examination came, Uncle Wang frowned, it turned out that his alanine aminotransferase and aspartate aminotransferase have a big upward arrow, which means that the indicators are abnormally high.
Then Uncle Wang took the physical examination report to find the doctor to solve the puzzle, the doctor saw that glutaminase was 164U/L, and glutaminase was 109U/L, which was indeed very serious, and the normal indicators of these two were about 40, which was more than double the normal value, so the doctor said to Uncle Wang: Your liver condition is very poor!
It turns out that aspartate aminotransferase mainly exists in the mitochondria of hepatocytes, while alanine aminotransferase is mainly distributed in the cytoplasm of hepatocytes, which is not present in large quantities in the blood under normal circumstances, and when hepatocytes are damaged and the cell membrane is ruptured, then the alanine aminotransferase and alanine aminotransferase present in it will be released, and then enter the blood, resulting in an increase in the concentration of aspartate aminotransferase and alanine aminotransferase in the blood.
Therefore, these two aminotransferase indicators can directly reflect the health level of the liver, and the doctor also used this to conclude that Uncle Wang's liver health is very poor.
The doctor told Uncle Wang that there are many reasons for the increase in aminotransferase indicators, first of all, viral hepatitis is the biggest culprit, these viruses will continue to replicate and proliferate in liver cells, causing immune cells to constantly attack liver cells, causing a large number of liver cells to damage and die, so that liver cells release a large number of aminotransferases, if the aminotransferase index in the body rises sharply, then you can consider the possibility of acute viral hepatitis, and chronic hepatitis will also lead to a slow increase in aminotransferases.
Uncle Wang said that he has no history of hepatitis, and the doctor said that drugs or alcohol can also damage liver function, resulting in abnormal elevation of aminotransferases, and the metabolism of many drugs needs to be carried out in the liver, so long-term use of these drugs will lead to damage to liver function, and alcohol is also very harmful to the liver, the content of aminotransferases is positively correlated with alcohol intake, and abstinence from alcohol can effectively reduce the content of aminotransferases, and long-term drinking may lead to liver fibrosis, liver cirrhosis and even liver cancer.
And Uncle Wang is an old drunkard, and Uncle Wang realized that the abnormal elevation of his transaminases was caused by his perennial drinking. But looking at his two aminotransferase numbers, one high and one low, Uncle Wang had questions again, he was very concerned about which number was higher and more dangerous, and which number was more important for aspartate aminotransferase and alanine aminotransferase, and then he asked the doctor his own questions.
The doctor was happy to answer Uncle Wang's question, and the doctor said that he had previously understood the location of these two aminotransferases, so for alanine aminotransferase, a slight hepatocyte injury may lead to the release of alanine aminotransferase into the blood in the cytoplasm, and for aspartate aminotransferase, he is mostly present in the mitochondria, so if you want it to be released into the blood, first of all, the cell membrane of the hepatocyte must be damaged, and the mitochondria also need to be destroyed.
When the mitochondria are damaged, it means that the liver cells have been seriously damaged, so alanine aminotransferase is more sensitive than aspartate aminotransferase, so we can notice that in Uncle Wang's examination indicators, alanine aminotransferase is higher than aspartate aminotransferase, and the increase of alanine aminotransferase is also more dangerous than the increase of alanine aminotransferase, which indicates that the damage to the liver is more serious.
At this time, Uncle Wang finally figured out what the indicators of alanine aminotransferase and aspartate aminotransferase represented, and knew which of the two aminotransferases was more dangerous, and Uncle Wang, who knew that his liver health was not good, made up his mind to take care of his liver. And according to Uncle Wang's etiology and symptoms, the doctor prescribed compound glycyrrhizin tablets.
This is a hepatoprotective drug for ethanol liver injury, and he can also reduce inflammation, anti-allergies, and improve the immune response of the liver, so it also has a good therapeutic effect on viral hepatitis, and can also promote the self-repair of liver cells, protect the stability of liver cells, thereby improving the liver function that has been damaged, compared with another drug for the treatment of liver disease, silybinin, it has a more significant effect on chronic liver disease.
Uncle Wang began to take drugs actively after returning home, and he changed his previous free and easy, and began to look for ways to nourish the liver everywhere, but, not to mention, the efforts immediately paid off, in April 2019, Uncle Wang went to recheck, and the alanine aminotransferase index became 53U/L
The aspartate aminotransferase has become 42U/L, which is very close to normal, you must know that the damage to the liver is also difficult to reverse, often only the early fatty liver is easy to return to normal, and for an old drunkard like Uncle Wang, it can be said that it is not simple to quickly control the aminotransferase index within five months.
Therefore, the doctor was also very curious, and he asked Uncle Wang: Have you taken some other medicines, why are the indicators of the two aminotransferases suddenly returning to normal, and now the control is very good, which is worthy of praise!
In the face of the doctor's praise, Uncle Wang was also flattered, and at the same time he also said: I only ate the compound glycyrrhizin tablets you prescribed, but I learned about the four methods of nourishing the liver on the Internet, according to these four methods I insist on every day, I didn't expect it to be so effective, I have reduced the value of these two aminotransferases so much in just five months!
Don't drink alcohol, this is the simplest and most important one, alcohol is the most harmful substance to the liver, alcohol will affect the metabolism of the liver, cause metabolic dysfunction, and will also lead to liver cell damage and even death, resulting in alcoholic hepatitis, fatty liver, liver cirrhosis, liver cancer and other diseases, so quitting alcohol is the most important step to protect liver health, and no matter what causes the decline in liver function, then it is always not wrong to quit drinking first, and the same is true for elevated aminotransferases.
Pay attention to the use of medicine, because of the age, Uncle Wang sometimes has to take all kinds of drugs, then there are many drugs will have a serious impact on the liver, some will increase the burden on the liver, some will directly damage the liver, so Uncle Wang after a detailed understanding, arranged his own unique way of taking medicine, first of all, for some miscellaneous health products, Uncle Wang did not eat all, and then some drugs with serious damage to the liver, Mr. Wang consulted the doctor and made a replacement, and some can not be replaced, but also carried out hepatoprotective treatment when taking medicine, reducing the toxic side effects of drugs on the liver。
Pay attention to rest, this is two things, one is from the sleep aspect, to ensure adequate sleep, this is because the liver is an important detoxification organ, detoxification work at night, if you stay up late, it will lead to the cessation of detoxification, resulting in the accumulation of liver endotoxins, and finally lead to liver damage, and then overwork will also lead to abnormal metabolism, resulting in damage and necrosis of liver cells, thus showing abnormal elevation of aminotransferases, so pay attention to rest.
Pay attention to the mood, the liver is happy and depressed, indicating that the liver is deeply affected by emotions, and bad emotions will affect the health of the liver, so try to avoid being in negative emotions, and keep a comfortable mood and peace of mind.
In addition, you should also pay attention to your diet, eat less fatty foods, and exercise more, which can also help maintain the health of the liver.