Recently, a number of important scientific research achievements in the fields of medicine, life science, materials, chemistry and other fields of Tongji University have been published in international authoritative journals and have attracted attention from the academic community.
Providing a new perspective on diabetes intervention
同济大学医学院/附属东方医院章小清/刘玲/房玉江团队，在《细胞·代谢》（Cell Metabolism）上发表了题为“Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells”的研究成果。 该研究首次在体内证实了胞内pH-Smad5信号通路的生理病理功能，揭示了这一通路异常在糖尿病发病中的病理生理机制，以及通过模拟胞浆碱化来改善糖尿病胰岛素分泌不足表型，为糖尿病的防治提供了新的思路。
Unraveling the mechanisms underlying the generation and maintenance of alertness
The team of Song Jianren from the School of Medicine of the University published a research result entitled "Serotonergic modulation of vigilance states in zebrafish and mice" in Nature Communications. This study is the first to unravel the intrinsic mechanism by which 5-HT neurons in the nucleus of the middle suture shape the alert state of the zebrafish and mouse brains at the neural circuit level in a non-traditional activation manner, contributing to the understanding of the interactions between neuromodulators and neural circuits necessary for the production of behavioral states.
Unraveling early embryonic development and cell fate decisions
The research team of Shaorong Gao/Cizhong Jiang/Rui Gao/Jiayu Chen from the School of Life Science and Technology published a research paper entitled "Defining a TFAP2C-centered transcription factor network during murine peri-implantation" in the journal Developmental Cell. This study revealed the regulatory network centered on the transcription factor TFAP2C in the early embryonic development stage of mice, and proposed that the combination of metabolism, epienvironment and genetic information jointly regulate the binding of TFAP2C, thereby driving the smooth progress of embryonic development and helping researchers better understand early embryonic development and cell fate determination.
To reveal the dynamic patterns and regulatory models of CTCF in early embryos
Yawei Gao/Daniel Zhang/Shaorong Gao's team from the School of Life Science and Technology published a research paper titled "ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice" online in Genes & Development. This study was the first to map the CTCF binding dynamics of mouse preimplantation embryos, discovered the species-specific transposon-mediated cleavage phase-specific CTCF binding characteristics, and discovered the ADNP-mediated CTCF binding restriction during blastocyst differentiation, which is of great significance in understanding transposon regulation of development and genome evolution.
It provides feasible guidance for hydrogen production by electrolysis of water with single-atom catalysts
Nature Communications published a research paper "Facilitating alkaline hydrogen evolution reaction on the hetero-interfaced Ru/RuO2 through Pt single atoms doping" by Jiwei Ma's team from the School of Materials Science and Engineering and his collaborators online. In this study, an efficient alkaline water electrolysis catalyst for hydrogen production was prepared by designing a Ru/RuO2 composite structure doped with trace Pt single atoms in a heterogeneous interface, which greatly improved the catalytic performance of alkaline HER while reducing the cost of the catalyst, and using advanced in-situ technology and theoretical calculations to reveal the reaction mechanism of the catalyst, which provided feasible guidance for the development of high-performance and low-cost noble metal-based basic hydrogen evolution catalysts, and was expected to be applied to the actual production of H2.
Preparation of piezoelectric ceramics with more efficient energy conversion
The research team of Jiwei Zhai from the School of Materials Science and Engineering published the results in Nature Communications with the title of "Multiscale reconfiguration induced highly saturated poling in lead-free piezoceramics for giant energy conversion". In this study, T-xBHT textured piezoelectric ceramics were prepared based on the template crystal growth method and the two-step sintering method by using the texturization process and the synergistic optimization of the medium-entropy-induced NPB phase boundary strategy, which exhibited excellent piezoelectric energy harvesting and ultrasonic transducer characteristics, and had strong competitiveness in both lead-free and lead-based piezoelectric ceramics. This study not only demonstrates a new idea for the design of high-performance KNN-based piezoelectric ceramics, but also establishes a close relationship between piezoelectric properties and potential multi-scale structures.
It provides a new idea for the precise construction of quaternary carbon and tertiary carbon chiral center compounds
化学科学与工程学院杨泽鹏课题组研究成果以“Enantioselective Construction of Quaternary Stereocenters via Cooperative Photoredox/Fe/Chiral Primary Amine Triple Catalysis”为题在线发表于国际知名期刊《美国化学会志》（Journal of the American Chemical Society）。 该研究利用外球机制机理，通过光氧化还原/铁/手性伯胺三重协同催化的策略，成功构建了一系列季碳手性中心化合物，为该类化合物的精准构筑提供了一种新思路。
近日，该课题组也实现了一例非活化烷基醇（β-羟基酮）与芳基溴的立体汇聚式脱氧还原偶联反应，相关研究成果以“Ni-catalyzed enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohols and aryl bromides”为题在线发表于国际知名期刊《自然·通讯》（Nature Communications）。
Greatly improve the nonlinear optical performance of 2D materials
The research team of Zhipeng Huang and Chi Zhang from the School of Chemical Science and Engineering published the research team of "Prominent Nonlinear Optical Absorption in SnS2-Based Hybrid Inorganic–Organic Superlattice" in the internationally renowned academic journal Advanced Functional Materials. In this study, quaternary ammonium ion intercalation achieves the simultaneous improvement of the nonlinear optical absorption coefficient and modulation depth of two-dimensional materials (SnS2), and proposes that dielectric enhancement is the main mechanism for improving the nonlinear optical performance of organic and inorganic superlattices, and also shows that organic ion intercalation can be an effective strategy to improve the nonlinear optical absorption performance of two-dimensional materials.
Achieve high performance and long life of zinc-ion batteries
The research results of Mingxian Liu's team from the School of Chemical Science and Engineering were published in Chemical Science, a well-known international journal in the field of chemistry, with the title of "In situ Nafion-nanofilm oriented (002) Zn electrodeposition for long-term zinc-ion batteries", and was selected as the cover article of the journal. In this study, a novel electrolyte with perfluorosulfonic acid resin (Nafion) as an additive was designed, which significantly improved the zinc ion deposition/stripping efficiency, and obtained dendritic zinc anode and long-life zinc-ion batteries.
近日，该团队设计了多电子双极型四硝基卟啉大环有机正极材料，构建了高能量密度和长循环寿命的锌-有机电池，相关成果以“Multielectron Redox-Bipolar Tetranitroporphyrin Macrocycle Cathode for High-Performance Zinc-Organic Batteries”为题发表于国际知名期刊《德国应用化学》（Angewandte Chemie International Edition）。 此外，该团队综述论文以“Non-Metal Ion Storage in Zinc−Organic Batteries”为题，在线发表于国际知名期刊《先进科学》（Advanced Science）。
An ultra-sensitive auditory-olfactory light-responsive flexible bionic sensor was fabricated
The research results of Bing Yan's team from the School of Chemical Science and Engineering are based on the research results of "Biomimetic Eu@HOF photoactivated sponge as ultrasensitive auditory and olfactory sensor for infrasound wave monitoring and bimodal information integration" The title was published online in the internationally renowned journal Advanced Functional Materials. This study skillfully integrates the idea of biomimetics into the design of hydrogen-bonded organic framework light-activated devices, and fabricates an ultra-sensitive auditory-olfactory light-responsive flexible bionic sensor, which can be applied to the monitoring and bimodal information integration of physically stimulated infrasound and chemically stimulated volatile gases at the same time, which is very promising in realizing bimodal interaction, simulating complex biological economic systems, and promoting environmental monitoring, disaster early warning and medical care.
不久前，《先进功能材料》（Advanced Functional Materials）还以“Smart Multiple Photoresponsive Tongue for Sensing Umami, Sour and Bitter Tastes Based on Tb3+ Functionalized Hydrogen-Bonded Organic Frameworks”为题，发表了该团队另一成果。 该研究通过将荧光和磷光信号结合，开发了一种具有多模式光响应的智能味觉传感器，可以有效识别出鲜味、酸味和苦味。
It provides theoretical guidance for the realization of highly selective electrosynthesis coupled hydrogen production
化学科学与工程学院赵国华团队研究成果以“Accelerated Dynamic Reconstruction in Metal‐Organic Frameworks with Ligand Defects for Selective Electrooxidation of Amines to Azos Coupling with Hydrogen Production”为题，在线发表于国际知名期刊《德国应用化学》（Angewandte Chemie International Edition）。 该研究通过配体缺陷调控金属有机框架（MOFs）的电子结构并暴露其不饱和位点，以促进偶氮电合成（ESA）耦合制氢催化剂的重构。 该研究深入揭示了水相ESHP系统中MOFs电催化剂重构过程和高活性的起源，为调节电催化剂重构以实现高选择性ESHP提供了理论指导，具有巨大的工业应用潜力。
Enables selective conversion of polyols
Tao Xu's research group in the School of Chemical Science and Engineering has developed a new method for the direct deoxidation of alcohols based on exogenous radical addition to phosphorus radical intermediates, and the related research results are based on "Deoxygenative Transformation of Alcohols via Phosphoranyl Radical from Exogenous Radical Addition" It was published online in Angewandte Chemie International Edition, a well-known international academic journal in the field of chemistry. This novel strategy is expected to play an important role in the field of organic synthetic chemistry because it can achieve the selective conversion of polyhydroxyl compounds and be used to quickly obtain important pharmaceutical intermediates that were difficult to obtain by previous methods.
Achieve high-efficiency photocatalytic CO₂ reduction to ethanol
化学科学与工程学院费泓涵课题组研究成果以“Modulating Inorganic Dimensionality of Ultrastable Lead Halide Coordination Polymers for Photocatalytic CO2 Reduction to Ethanol”为题，发表于国际知名期刊《德国应用化学》（Angewandte Chemie International Edition）。 该研究通过有机配体的单原子变化（NH vs. CH2）来调控有机卤化铅的维度，以亚氨基基团与层间碘化铅组份发生配位，实现二维到三维的结构转变，构建了一例具有高水稳定性的三维碘化铅配位聚合物，大幅降低了激子结合能，在水蒸气环境下光催化CO2还原至乙醇。
It provides new ideas for the development of CPL materials with dynamic tweaking
Guofeng Liu's research group in the School of Chemical Science and Engineering has developed a new method for circular polarization luminescence enhancement and chiral flipping based on multi-order assembly regulation of metal-organic triple helix, and the related research results are called "Hierarchical Self-Assembly Promoted Circularly Polarized Luminescence Enhancement and Handedness Inversion of". Metal-Organic Helicate" was published online in the Proceedings of the Chinese Chemical Society (CCS Chemistry). This novel coordination assembly strategy can easily construct a variety of metal-organic triple helix structures, and amplify and control the CPL properties of materials through hierarchical assembly, which provides a new idea for in-depth understanding of chiral transfer mechanism and the development of dynamically tunable CPL materials.
Aiming at the world's frontier of science and technology, facing the major strategic needs of the country, Tongji University bravely shoulders the important task of the era of scientific and technological innovation, devotes itself to scientific research, strives to achieve more breakthroughs from "0 to 1", helps high-level science and technology to become self-reliant and self-reliant, and injects new momentum into accelerating the development of new quality productivity.
Editor: Wu Baixin
Source: Tongji University
*Please indicate that the reprint is from the official WeChat of Shanghai Yangpu