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"On March 21, 2024, Wisdom Buds' Bio Biological Sequence Database launched the world's first chemical modification search function for sequences, setting a new milestone in the field of bioinformatics. ”
来源:IPRdaily中文网(iprdaily.cn)
As the world's leading biological data resource, Wisdom Buds' Bio Biological Sequence Database ("Bio") has once again set a new milestone in the field of bioinformatics by launching the world's first chemical modification search function for sequences on March 21, 2024. This is another innovative breakthrough after the innovation in 2023, Bio has not only established an unrivaled competitive advantage in the industry with its excellent functions and in-depth data coverage, but also has been recognized as a leader in the industry!
The chemical modification search function of Bio biological sequence database is officially launched!
Basic Concepts – What is Chemical Modification?
Chemical modification of a sequence refers to changes in the structure of biological macromolecules such as nucleic acids (DNA, RNA) or proteins. These modifications involve the introduction of chemical groups or other structural changes at specific sites in the sequence to improve their properties or functions. For example, 2'-oxymethyl (2'-OMe) modification: In the nucleotide of siRNA, the 2'-hydroxyl group is replaced by a methyl group, which can improve the stability of the siRNA and enhance resistance to RNases. Similarly, phosphorothioate modifications, cholesterol modifications (5'-Chol, 3'-Chol) and so on. Chemical modification methods can be selected and combined according to experience, patent literature, and specific experimental needs and application scenarios to improve the performance of the target product and improve the therapeutic effect.
Why do you do a sequential chemical modification search database?
With the soaring popularity of small nucleic acid peptides, sequence design and modification is a key step in the development of effective drugs in these fields, and it is also an important strategic point for IP protection. However, there is currently no database in the world that can achieve one-click search by modification type and modification loci, covering all relevant sequences and patents, resulting in professionals having to rely on time-consuming keyword searches and expert screening.
Through in-depth research on international pharmaceutical companies, the R&D and IP professionals of Wisdom Buds Bio have revealed a real challenge: in the context of the lack of efficient automation tools, R&D and IP professionals have to rely on the strategy of initial goal setting and manual search of patent information, which needs to be updated frequently. The obscure description of chemical modifications in patent documents further complicates this process and significantly increases the difficulty of infringement risk management.
The results highlight the urgency and importance of chemical modification sequence search in two key areas:
1) R&D efficiency improvement: An effective chemical modification search tool can help R&D teams accurately identify and analyze the modification status of target proteins, thereby accelerating the process of drug discovery and molecular design, and improving R&D efficiency and the transformation potential of results.
Target identification: For R&D teams focused on signaling mechanisms, retrieving sequences with specific chemical modifications, such as phosphorylation, can accelerate the drug discovery process by pinpointing and targeting potential target proteins.
Drug optimization: By analyzing the effects of different chemical modifications on the half-life and stability of molecules, developers can optimize the performance of drug candidates to achieve higher efficacy and safety standards.
2) IP strategic protection: An in-depth understanding of chemical modifications and rapid retrieval are essential for IP professionals to help maintain their intellectual property advantages and avoid potential legal risks in the fierce market competition.
Patentability Analysis: The IP team assesses the novelty of a particular chemical modification by carefully combing through the existing literature and patent information. By comparing the target modification with the known modification, they were able to identify unique features that might support a patent application.
FTO Assessment: IP experts need to conduct a comprehensive review of existing intellectual property rights to determine whether newly discovered chemical modifications may infringe the patent rights of others. This includes analysing the use of specific modifications, relevant documentation, etc., to ensure that R&D activities do not give rise to IP disputes.
Launched a world-first feature that allows users to efficiently search for chemical modifications of sequences
Users who previously could only view chemical modifications by sequence, can now use the Wisdom Buds Bio chemical modification search function to search for sequences and patents directly by chemical modifications, eliminating the need for manual collation. The traditional time-consuming and laborious chemical modification retrieval problem has been solved in the Bio chemical modification retrieval function of Wisdom Buds.
Figure: Bio Bio Sequence Database Chemical Modification Search Portal
Traditional Challenge 1: The lack of uniform standards for the description of sequence modifications in patent documents has led to significant variations. When conducting a keyword search, users must manually include all possible modifications, which can easily lead to the omission of key patents.
Bio's technological breakthrough: We have successfully established a standardized search system for many sequence modifications, and will continue to iteratively optimize to ensure that users can accurately and comprehensively obtain the information they need.
Figure: Standardized chemical modification system can be checked
Traditional challenge 2: Users face great difficulty in searching for sequences with the same modification type, especially at specific sites. The existing workflow is complex, and it usually requires a combination of basic sequence search and modifier keyword search, and adopts a multi-strategy parallel approach.
Bio's technological breakthrough: With our chemical modification search function, users can directly search for sequences of specific modification types without sequence information, greatly simplifying the search process and improving the accuracy and efficiency of the search.
Figure: Disordered search provides deeper insight into R&D ideas
Traditional Challenge 3: Unable to visualize the entire chemical modification search results. Looking at the chemical modifications in each patent individually may leave out some key information, such as common modification types, optimal modification sites, or hot R&D trends in the field.
Bio's technological breakthrough: Our list page, Modification Overview, allows users to quickly identify the distribution of chemical modifications across the data results and export reports.
Figure: "Retouching Overview" at a glance retouching the whole picture
A detailed display of the data, technology and products behind the innovative breakthroughs
Sources of chemical modification data
Based on the manual collation of 670,000 data by the expert team of Wisdom Buds and the extraction of 840,000 chemical modification data in the patent sequence list, a total of 1.5 million modification sequences are available for users to search and query, creating a chemical modification standardization system covering 9 categories and 382 subcategories.
The global sequence alignment algorithm is introduced
Advanced global alignment algorithms for most sequences with significant similarity, sometimes returning better results, especially for short sequence retrieval.
The product is convenient and easy to use
The search interface is clear and easy to use, with complete functions, comprehensive and detailed search result data, and can support export reports to trace the source of hit modification data. The following is the product display.
a. Construct a search query
b. Search results page
c. Grooming overview generates a grooming search report
d. View sequence details
In the future, we will continue to optimize and iterate
1. Improve the accuracy and coverage of chemical modification standardization, and users can accurately search for more specific modifications.
2. Expand the scope of modification coverage in patents to cover tables, full texts, and pictures, and further better support users to search for modification sequences.
3. Improve the visual display of results, provide intuitive data interpretation, and clearly identify the relationship between different data.
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(Original title: Industry Innovation!Following the "General Search", the world's exclusive "Chemical Modification Search" technology has made a shocking debut)
来源:IPRdaily中文网(iprdaily.cn)
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