On January 25th, Juzi Biotech held the "Recombinant Collagen Empirical Science" Recombinant Collagen Empirical Scientific Research Report and Kelijin Brand New Product Launch Conference. The conference brought together authoritative experts in the industry, with the help of the cutting-edge two-photon microscopic imaging technology independently developed by the mainland, to deeply discuss the latest empirical scientific achievements of recombinant collagen, promote the deep integration of scientific research and clinical practice in the recombinant collagen industry, and learn about the future development trend of recombinant collagen.
△Ms. Fang Juan, Senior Vice President of Giant Biotech, delivered an opening speech
In recent years, the recombinant collagen industry can be described as the "dark horse" of the functional skin care track, with rapid development and broad prospects. However, at the same time of rapid development, it is also accompanied by many doubts, such as "can recombinant collagen be absorbed through the skin?" and "can recombinant collagen really promote the body's own collagen production?" and other issues have become the focus of attention of the industry and consumers, and answering the public's doubts is undoubtedly the only way for the steady development of the recombinant collagen industry.
As the first company in China to independently design, develop and produce recombinant collagen using synthetic biology technology platform, Giant Biotech has been leading the recombinant collagen industry with scientific research strength for more than 20 years, and actively assumes the responsibility of promoting the orderly development of the industry. Today, Giant Bio has formed the leading scientific research and technological advantages of recombinant collagen [1].
It is understood that the Giant Biomolecule Bank has more than 40 kinds of recombinant collagen reserves, and is currently the only company that publicly discloses that it can produce full-length single-chain recombinant collagen, covering all functional areas and all functional active sites。
In response to many doubts in the development of the industry, as a pioneer of recombinant collagen, Juzi Bio has also been promoting the industry standardization process with its own strength, and has taken the lead in introducing cutting-edge detection technology to visualize the efficacy of products.
In September 2023, the "Determination Method for Promoting Collagen Secretion in Human Cells" and "Transdermal Absorption Determination Method for Recombinant Collagen" led by Giant Biotech were officially released, providing standard basis and method guidance for the evaluation of biological functions of recombinant collagen. In this press conference, Giant Biotech demonstrated a number of empirical test data reports on the raw materials of C5HA recombinant collagen biomimetic combination [2] with new technologies, which is an important measure to break the public's doubts about recombinant collagen with scientific evidence.
It is understood that the cutting-edge detection technology adopted by Giant Bio is the two-photon microscopic imaging technology independently developed by the mainland. In 2023, the Shenzhou-15 astronaut crew used the space station two-photon microscope independently developed by the mainland to carry out an in-orbit verification experiment and succeeded. This is the first known time in the world that two-photon microscopy has been used to obtain three-dimensional images of the epidermis and superficial dermis of astronauts' skin during space flight. This cutting-edge technology provides a technical means for the effectiveness testing of functional ingredients.
In this press conference, Professor Duan Zhiguang, Professor of the Institute of Biomedicine of Northwest University and Chief Technology Officer of Giant Biotech, shared a special report on "Biomanufacturing of Multi-type Recombinant Collagen and Efficacy of C5HA Biomimetic Composition". According to the report, Juzi Biotech took the lead in displaying the raw skin detection results of the C5HA recombinant collagen biomimetic combination [2] with a two-photon 3D dynamic model, and used the new technology of laser scanning confocal microscopy and two-photon excitation to use it for microscopic imaging of skin biological cells to image tissues and dynamic processes at different depths of the skin, and carried out a series of authoritative tests through the transdermal absorption test and human efficacy test of the 3D full-thickness skin model, effectively demonstrating the C5HA recombinant collagen biomimetic combination [2] Transdermal absorption of raw materials and the ability to promote collagen production in the skin.
△Professor, Institute of Biomedicine, Northwest University,
Professor Duan Zhiguang, Chief Technology Officer of Giant Biotech
The visual presentation of scientific evidence can not only effectively answer the doubts of the public, but also allow consumers to feel the effect of the product more intuitively in the process of using the product, enhance the persuasiveness of the product, and provide a strong evidence for promoting the wider application of recombinant collagen, a Chinese ingredient.
In the roundtable forum on "Innovation and Application Exploration of Recombinant Collagen", Professor Yang Rongya, Vice President of China Plastic Surgery Association, Professor Li Qiong, Vice President of Shanghai Daily Chemicals Industry Association and Consultant of Beauty Practice, and Professor Duan Zhiguang, Professor of the Institute of Biomedicine of Northwest University and Chief Technology Officer of Giant Bio, discussed the prospects of recombinant collagen in clinical application. Professor Duan Zhiguang mentioned that for a long time, Giant Biotech has been actively expanding its layout in the field of life sciences and professional beauty. For example, in the field of life sciences, targeted drugs for damaged human skin, organs, and collagen, and in the field of professional beauty, there are also research and development of Class III medical device products, such as glabellar line filler injection products, nasolabial fold injection filling products, etc.
△ "Innovation and Application Exploration of Recombinant Collagen" roundtable forum
In fact, in recent years, Giant Biotech has been striving to get close to consumers and pass on professional skin care knowledge to consumers in a way that is closer to life and easier to understand. In the future, Giant Biotech will also build a bridge of better communication with consumers through more visual experiments and evidence, so that consumers can participate more in the link of science communication.
Finally, Mr. Wang Xiaojun, Director of Product R&D of Giant Biotech, released a blockbuster new product of the Kelijin brand of Juzi Biotech - Kelijin Film Eye Cream [4], which adopts the refined "432" formula ingredient system: Quadruple Collagen [2] x Triple Peptide [5] x Dual A Alcohol [6], with C5HA recombinant collagen biomimetic combination [2] as the core active ingredient, and improves the "collapse, wrinkles, dullness and dryness" around the eyes in different regions, sub-mechanisms and multiple targets Four major problems, and invited staff on site to compare the VISIA test before and after the use of the product, and show its product strength with empirical results.
△ Mr. Wang Xiaojun, Director of Product R&D of Juzi Biotech
Since its establishment in 2000, Giant Biotech has been committed to the in-depth research and exploration of synthetic biology technology, combining advanced technology with scientific evidence, continuously promoting technological innovation and breakthroughs, and actively leading the standardized, healthy and scientific development of the industry in the development of the industry. The demonstration of the efficacy of recombinant collagen with new technology not only allows consumers to visualize the ingredients and product efficacy, but also lays a solid foundation for the clinical application of recombinant collagen and provides an important basis for the promotion of related products.
It is believed that in the future, Giant Bio will continue to use more science and technology to let consumers witness the hard power of recombinant collagen, and win the recognition and trust of more consumers with empirical evidence.
[1] It refers to more than 40 kinds of proteins, including the natural full-length sequence with the largest molecular weight, some functional fragment repeats, splicing combinations, and the smallest small molecule with the smallest molecular weight; the amino acid sequence of recombinant type III collagen is the full-length sequence of the α1 chain of human type III. collagen, and it is 100% homologous to human type III. collagen by mass spectrometry; the molecular weight of GAA is 217Da, which is the smallest recombinant collagen peptide that can be mass-produced on the market
[2] Refers to the C5HA recombinant collagen biomimetic combination, which is a mixture of recombinant type I human collagen, recombinant type III human collagen, recombinant human collagen, and mini small molecule recombinant collagen peptides, which is shown as "soluble collagen" in the ingredient list, and has good anti-wrinkle and firming effects
[3] From Xinhuanet's "Mainland's Independently Developed Space Station Two-Photon Microscope Obtained the First Three-dimensional Image of Astronaut Skin" released by Xinhuanet on February 27, 2023
[4] Kelijin Film Eye Cream is the nickname of the product, and the full name of the product is Kelijin Recombinant Collagen Activating Three-dimensional Firming and Lightening Wrinkle Essence Eye Cream
[5] Refers to supramolecular hexapeptides, snake-like peptides, and arginine/lysine polypeptides, of which supramolecular hexapeptides are shown as "acetyl hexapeptide-8" in the composition list, and "dipeptide diaminobutyrylbenzylamide diacetate" in the ingredient list of snake-like peptides
[6] Refers to HPR and lutein, of which HPR is shown as "hydroxypinazone retinoate" in the ingredient list