When customers buy cough syrups containing ethanol, pharmacies must warn that it is forbidden to take them with cephalosporins.
On 2022-05-31, the State Food and Drug Administration issued an announcement on revising the drug instructions of snake gallbladder Chuanbei preparations:
Snake bile:
1. It should not be used with Chuanwu, Chuanwu, Caowu, Caowu, Aconite and its preparations.
2. This product contains a small amount of ethanol (alcohol), people who are allergic to alcohol should use it with caution, or consult a physician before use.
3. This product contains a small amount of ethanol (alcohol), and it is not recommended to use it in combination with cephalosporins, metronidazole, tinidazole, ketoconazole, furazolidone and other drugs during the medication.
Top causes:
The main components of snake gallbladder shellfish liquid are snake bile and flat fritillary. Aconitum anti-fritillary, melon, banxia, baijiu, baiji.
The excipients of snake gallbladder shellfish liquid contain ethanol, which can react disulfiram like with antibacterial drugs such as cephalosporins.
What is a disulfiram-like reaction?
The so-called disulfiram-like reaction refers to the ingestion of ethanol after taking cephalosporins, which leads to the accumulation of acetaldehyde in the body and produces a toxic reaction.
The main manifestations are: chest tightness, shortness of breath, laryngeal edema, cyanosis of the lips, dyspnea, increased heart rate, decreased blood pressure, hallucinations, trance, and even anaphylactic shock.
In short, deadly.
Therefore, when customers buy cough syrup containing ethanol, pharmacies must remind that it is forbidden to take it with cephalosporins.
These 6 kinds of cough syrup cannot be used in combination with cephalosporin
1. Cough and asthma syrup
Indications: cough, expectorant, asthma. It can be used for cough and wheezing, pale sputum caused by cold phlegm obstruction of the lungs, or chronic bronchitis with the above syndromes.
The main ingredient of cough and asthma syrup is Manshan red and contains 20%~28% ethanol.
2. Nourish yin and clear lung syrup
Indications: It is suitable for upper respiratory tract infection, acute bronchitis, pneumonia and other diseases caused by lung heat injury. It can be used for dry and sore throat, dry cough, little or no phlegm, etc.
Yangyin Qinglung syrup excipients contain ethanol and cannot be used in combination with cephalosporin.
3. Dextromethorphan guaifenesin syrup
Mechanism of action: dextromethorphan hydrobromide is a central antitussive, the antitussive effect is equal to or slightly stronger than codeine, and long-term use is non-dependent and tolerable.
Guaifenesin is an expectorant that can increase the secretion of respiratory glands, dilute sputum, and make it easy to cough up.
Dextromethorphan guaifenesin syrup uses ethanol as an excipient and cannot be used in combination with cephalosporins.
4. Dextromethorphan hydrobromide syrup
Indications: Dextromethorphan hydrobromide 2mg per ml. It can be used for dry coughs, including coughs caused by upper respiratory tract infections (such as colds and pharyngitis), bronchitis, etc.
It is important to note that dextromethorphan hydrobromide syrup uses ethanol in the excipients.
5. Guaifenesin syrup
Mechanism of action: Contains 20mg of guaifenesin per ml. Guaifenesin is a stimulant expectorant, which can stimulate the gastric mucosa, reflexively cause an increase in the secretion of respiratory glands, dilute the sputum, and make it easy to cough up, thus producing expectorant effect. Therefore, it is contraindicated in patients with pulmonary hemorrhage, nephritis, and acute gastroenteritis.
Guaifenesin syrup uses ethanol as an excipient and cannot be used in combination if the customer has purchased cephalosporin.
6. Compound licorice oral liquid
Mechanism of action: The main components of licorice flow extract are glycyrrhizic acid and flavonoids, which have good antibacterial and antiviral effects. The compound camphor tincture contains opium tincture, which directly inhibits the cough center.
Among them, compound camphor tincture not only contains camphor and opium tincture (containing ethanol), but cannot be used in combination with cephalosporin.
Addendum: Oral solution containing ethanol
Warm reminder: Please follow the doctor's instructions for specific details!