Clinically, there are many patients with hyperlipidemia who take atorvastatin, and atorvastatin has two most symptomatic diseases, one is hypercholesterolemia and the other is coronary heart disease.
If the cholesterol content in the blood is greater than 6.45mmol/L, it is considered hypercholesterolemia, and if the problem is more serious and the cholesterol cannot be lowered for a long time, then atorvastatin needs to be taken.
Due to coronary artery disease caused by various reasons, patients will have myocardial ischemia, coronary atherosclerosis, hypercholesterolemia, etc., and if not treated in time, it may lead to myocardial infarction.
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There are many chronic diseases caused by high cholesterol, high blood lipids, and coronary heart disease, and taking atorvastatin is equivalent to solving the problem fundamentally, but there are also many contraindications to be aware of during taking it.
01
What does atorvastatin do?
Atorvastatin is a commonly used lipid-lowering drug whose main effect is to lower blood cholesterol and LDL cholesterol levels. Here are a few of the main effects of atorvastatin:
◆ Lowers cholesterol levels: Atorvastatin can inhibit the synthesis of cholesterol, thereby reducing cholesterol levels in the blood. This is of great significance for the prevention and treatment of diseases such as hypercholesterolemia and atherosclerosis.
◆ Stabilize plaques: Atorvastatin can stabilize atherosclerotic plaques and reduce the risk of plaque rupture and thrombosis. This has a positive effect on the prevention of cardiovascular events such as myocardial infarction, stroke, etc.
◆Anti-inflammatory effect: atorvastatin has an anti-inflammatory effect, which can reduce the inflammatory response of blood vessels and reduce the incidence of cardiovascular events.
◆Improve endothelial function: atorvastatin can improve endothelial function, promote the regeneration and repair of endothelial cells, thereby protecting the cardiovascular system.
◆Antiplatelet aggregation: atorvastatin can inhibit platelet aggregation and reduce the risk of thrombosis, which plays an important role in the prevention and treatment of cardiovascular diseases.
02
What foods and drugs should "atorvastatin" not be taken with?
Atorvastatin is a drug commonly used to lower cholesterol and prevent cardiovascular disease, however, it has some specific drug interactions and food contraindications that require special attention when using it. Here are some foods and medications that should not be taken with atorvastatin:
Grapefruit: The ingredients in grapefruit may affect the metabolism of atorvastatin in the liver, thereby increasing its blood concentration, which may lead to drug overdose and adverse reactions.
Red yeast rice, such as red yeast rice, red yeast rice products, etc., may affect the liver's metabolism of atorvastatin and increase its blood concentration.
Certain antifungal drugs, such as ketoconazole and itraconazole, may inhibit the metabolism of atorvastatin in the liver and increase its blood concentration.
Certain antibiotics, such as clarithromycin and erythromycin, may inhibit the metabolism of atorvastatin in the liver and increase its blood concentration.
Certain antidepressants, such as citalopram and sertraline, may inhibit the metabolism of atorvastatin in the liver and increase its blood concentration.
03
What is the best time to take atorvastatin?
The best time to take atorvastatin is usually in the evening or after dinner, this is because the synthesis of cholesterol peaks at night, so taking atorvastatin at night can better inhibit the synthesis of cholesterol, in addition, taking it after dinner is also beneficial for the absorption and utilization of the drug.
However, the specific best time to take it depends on the individual's situation and the doctor's advice, some patients may need to take it in the morning in order to better control cholesterol levels, in addition, the side effects of atorvastatin mainly include gastrointestinal discomfort, muscle pain, etc., so it is necessary to choose the appropriate time to take it according to the individual's physical condition and tolerance.
While taking atorvastatin, it is also necessary to pay attention to the dosage of the drug and how to take it, the dosage of atorvastatin needs to be determined according to the specific situation of the patient, too high a dose may lead to increased side effects, in addition, atorvastatin needs to be taken with food, so it is necessary to pay attention to the effect of diet on the absorption of the drug.
04
Who is prohibited from taking statins?
Statins are a type of medication that is commonly used to lower cholesterol and the risk of cardiovascular disease. However, some people may not be candidates for statins due to specific health conditions or drug interactions. Here are some people who are prohibited or need to be cautious about taking statins:
★ Pregnant and lactating women: Statins may have adverse effects on the fetus or baby, so pregnant and breastfeeding women should avoid taking them.
★ People with liver disease: Statins are mainly metabolized by the liver, so people with liver disease may need to take them with caution or use other cholesterol-lowering drugs as recommended by their doctor.
★ People with kidney disease: Statins can have adverse effects on the kidneys, so people with kidney disease need to be cautious about taking them or use other cholesterol-lowering drugs as recommended by their doctor.
★ Diabetics: Some studies suggest that statins may increase the risk of diabetes, so people with diabetes need to be cautious and monitor their blood sugar levels closely while taking them.
★ Older patients: Older patients may be poorly tolerated to statins and need to be taken with caution and under the guidance of a physician.
In addition, if you are taking other medications, especially anticoagulants, immunosuppressants, antibiotics, etc., it may also interact with statins and cause adverse reactions, so it is best to consult your doctor before taking statins to ensure your health and safety.