Hyaluronic acid
Also known as hyaluronic acid (HA), is an acidic mucopolysaccharide, hyaluronic acid is widely present in nature, in humans and various animals contain hyaluronic acid, some bacteria capsule also has a high content, these sources of different hyaluronic acid, its chemical mechanism is exactly the same, are a single disaccharide repeat structure, no species difference, which provides a material basis for the use of hyaluronic acid as a filler. For us humans, about 56% of the hyaluronic acid content in our body is located in the dermis layer of the skin, which is an important part of the volume in the dermis layer.
What does it do?
If people want their skin to be supple, they need hyaluronic acid.
The human body itself contains hyaluronic acid. Its water retention effect is obvious, and it is the strongest moisturizing substance found in the field at present. Hyaluronic acid can improve the nutritional metabolism of the skin, make the skin supple and smooth, and have the effect of removing wrinkles and increasing skin elasticity.
To put it bluntly, it is "skin elixir", and women are absolutely willing to spend money for the sake of face women
Two women in the hyaluronic acid industry, Jian Jun of Aimeke and Zhao Yan of Huaxi Biotechnology
Jian Jun who loves Meike
In 1985, he graduated from the Department of Business Administration of Tsinghua University and entered China Cereals, Oils and Food Import and Export Corporation.
In the 90s, with the rise of the boom of going abroad, Jian Jun quit his job at the iron rice bowl of the central enterprise and went to the United States to pan for gold.
In 2000, the ProCytech Biochemistry Laboratory in France developed an injectable synthetic gel and obtained marketing approval.
This beauty needle that can be used to fill in wrinkles, sunken scars and facial contouring on the flat area is very popular in Western countries.
Jian Jun felt this was an opportunity and established Yousen Biotechnology in 2002 to represent this medical beauty product in China.
In 2004, at the age of 41, Jian Jun quit his job in the United States and returned to China to start a business.
She founded Yingzhihuang Biotechnology Co., Ltd., which was renamed Aimeike the following year. In the old factory of a pharmaceutical factory in Changping District, Beijing, the road of independent research and development of hyaluronic acid began.
Aimeike: The company is valued at 130 billion
In 2009. Aimeike's first product "Yimei" came out and was approved for marketing by the State Food and Drug Administration, breaking the situation of relying on imports of hyaluronic acid for medical beauty.
Jian Jun said: "Based on the current stage of Aimeike's development, focusing is the best choice. ”
At present, Aimeke has five Class III sodium hyaluronate series products (i.e. hyaluronic acid products) approved by the State Food and Drug Administration, and obtained the Class III medical device registration certificate for poly-p-dioxone facial implant in May 2019.
Aimeke attaches great importance to R&D investment and product development, and the company continues to develop medical products in the field of medical cosmetology, including injection products containing polylactic acid for functional treatment of the skin, botulinum toxin type A drugs for injection, and recombinant protein drugs for injection for chronic weight management.
At present, the company's main products include Hi Ti, Avrai/Aimefei, and Bonida, accounting for more than 95% of the revenue.
Revenue from solution injectable products, including Hi Body and Yimei, contributed 75.2% of revenue. Due to product iteration, Yimei's revenue accounted for less than 1% in 2019. Therefore, in the current revenue structure, Hi Ti contributes nearly 70% of the company's revenue.
Hi body is a typical non-surgical light medical aesthetic project, compared with surgical projects, non-surgical projects have the characteristics of low single price, low risk, and less trauma, so the market acceptance is high.
Zhao Yan of Huaxi Biotechnology
In 2000, Zhao Yan, who played real estate, met Guo Xueping in the MBA class of Peking University.
Guo Xueping is a researcher at the Shandong Institute of Materia Medica, which cooperated with foreign capital to establish Freda Enterprise, which mainly produces hyaluronic acid, later hyaluronic acid.
In 2001, Huaxi International Investment Group, a subsidiary of Zhao Yan, invested in Shandong Freda Biomedical Co., Ltd.
According to public information, Shandong Freda, the predecessor of Bloomage Biotechnology, purchased the initial technology of fermentation method to produce medicinal hyaluronic acid from the Shandong Institute of Biopharmaceuticals. In response to the fourth inquiry from the Shanghai Stock Exchange, Bloomage Biotech revealed that the technology transfer fee of the project was 450,000 yuan, and it paid out the technology in a lump sum in August 2001.
In 2012, Shandong Freda Biopharmaceutical Co., Ltd. changed its name to Shandong Huaxi Freda Biopharmaceutical Co., Ltd.
In 2018, after a series of equity changes, Shandong Huaxi Freda Biopharmaceutical Co., Ltd. changed its name to Bloomage Biotechnology Co., Ltd., and since then Bloomage Biotechnology and Freda no longer have an equity relationship.
Bloomage Biotech: The company is valued at 60 billion
The main business of Bloomage Biotech is mainly divided into 4 categories.
1 Raw material product business: hyaluronic acid
Bloomage Biotech is the world's largest hyaluronic acid R&D, production and sales enterprise, accounting for 44% of the global raw material market.
2. Medical terminal product business
In the first half of 2022, the revenue of the medical terminal business (mainly medicine and medical beauty) was about 300 million, accounting for about 10% of the main business revenue of Bloomage Biotechnology
3 Functional skin care business
At present, Bloomage Biotech has a number of brand series such as "Runbaiyan", "Quadi", "Mibel", "BM Muscle Live", "Runxihe", "Bai Oben Set" and so on, and its product categories include sub-parabolic liquid, various creams and lotions, face masks, hand masks, eye masks, sprays, maternal and baby personal care, scalp care and some makeup products.
The functional skincare business has become the revenue pillar of Bloomage Biologics. In the first half of last year, the business achieved revenue of about 2.1 billion yuan, accounting for 72% of the company's main business income.
4 Functional food business, that is, hyaluronic acid products that can be eaten.