After staying up for a long time, I finally had a holiday, so I began to fly myself, surfing the Internet, chasing dramas, playing games, and it was already 2 a.m. when I came to the gods. Anyway, if I don't go to work tomorrow, I can sleep until 12 o'clock. Then as soon as the eyes are closed, it is the seventh day of the first month of the first month, the day to go to work, and I feel that the whole person is weak, listless, and sluggish...
At this time, the voice of the 2017 Nobel Prize winner seems to still echo in the ears. Yes, it's the clichéd, but relevant, biological clock. In 1984, three scientists discovered that fruit flies have a gene related to the biological clock, which synthesizes something called PER protein, which becomes more at night and less during the day, thus forming a "circadian rhythm". In 1994, Young discovered that there is another gene in the fruit fly that can synthesize the corresponding TIM protein, and this protein combined with the previous protein can prevent the gene from synthesizing the PRE protein, thereby regulating the amount of PER protein, which is the so-called biological clock.
1. History and Chronobiology
The biological clock, as the name suggests, is like an invisible clock in the organism. It is the intrinsic rhythm of the life activity of the organism and is determined by the temporal structure order in the organism. It ticks like a very sophisticated instrument, controlling every aspect of our body.
1. In the 18th and 19th centuries, botanists discovered that the movement of mimosa leaves had a cycle. In the 20th century, scientists Wilhelm Pfeffer, Anthonia Kleinhoonte, put the plant Yaknishopea in dark conditions and found that the leaves of Yasukasa are still rhythmic, suggesting that leaf movement is endogenously controlled by plants
Later, scientists Erwin Bünning, Hans Kalmus, Pittendrigh found in fruit flies that the time for fruit flies to hatch remained at the same point in time under continuous light, further proving that the rhythm was endogenous. The phenomenon was later found in other species, suggesting that circadian rhythms are universal. 2. In 1954, scientist Pittndrigh placed fruit flies under different temperature conditions and found that the hatching cycle of fruit flies does not depend on ambient temperature, revealing the temperature compensation effect of circadian rhythms.
2. Post-Holiday Rout: The Power of the Biological Clock
1. In addition to lack of energy, the disorder of the biological clock can also bring many problems, such as memory loss. In 2014, a team of researchers at Stanford University published a paper called Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing, which used the short-tailed pygmy hamster as a model and found that circadian rhythm disorders can lead to memory loss.
2. The team simulated human rhythm disorders while the genetic and physiological structure of the SCN remained intact by performing "phase shift interference" on short-tailed dwarf hamsters, and then detected their memory through the "T-maze" test and the "new object recognition" test.
The consequences of a disordered circadian clock may also include: diabetes, depression, obesity...