Uncle Zhu is 75 years old this year, although he prefers to smoke and drink before he retires, but his body has always been OK. However, in the night before January, when getting out of bed to urinate, suddenly dizzy and fell to the ground, the family rushed to contact 120 to send to the emergency department, after CT examination was diagnosed as acute cerebral infarction, fortunately found that in time still within the "golden four hours" of thrombolysis, after entering the green channel thrombolysis, it was out of danger of life.
After being discharged from the hospital, doctors kept him on imported aspirin enteric-coated tablets for anticoagulation. But because Uncle Zhu lives in the countryside, sometimes when aspirin is eaten, he goes to the village clinic to buy, but when he takes out the hospital medicine box, the doctor is difficult, saying that I only have domestic aspirin here, the manufacturer is different from you, the price is more than half cheaper, but the effect is almost the same, do you want it?
This also made Uncle Zhu feel difficult, thinking that he would not be able to save this money, or want to buy high-priced imported aspirin, saying that he still rode a motorcycle to buy in the town.
Dr. Lin will talk about the difference between generic drugs and imported drugs, the same is aspirin, why is the price difference of dozens of times? Is it a domestic drug cutting corners?
What is a generic drug?
Speaking of generic drugs, we will think of the anti-cancer drug Glenin in the movie "I am not a medicine god" that was fired a few years ago, a bottle of Glenin's brand medicine costs tens of thousands of yuan, while a bottle of Indian generic drugs with the same medicinal effect only costs a few thousand yuan.
In fact, want to develop generic drugs, not a simple copy, the difficulty is no less than re-development, some of the original drug patents have expired for many years, there are still no generic drugs listed, such as some inhalation preparations and long-acting sustained release injections. Because the original drug has various patent and non-patent barriers in terms of prescription and process technology, it needs to be overcome one by one.
And in the mainland, there is also a "generic drug consistency evaluation" assessment, which is strictly reviewed and supervised by the State Food and Drug Administration based on the prevailing technical standards in Europe and the United States, so the research and development to clinical trials are strictly in line with the original research and drug standards in Europe and the United States, so the quality and efficacy can still be comparable to imported drugs.
How big is the difference between 3 cents of domestic aspirin and 7 yuan of imported drugs?
The same aspirin, why is the price difference of dozens of times? Is it a domestic drug cutting corners? Before answering this question, let's first understand the double ten law of the pharmaceutical industry - a new drug from development to market, an average of 10 years and 1 billion US dollars investment. The difficulty of research and development of new drugs has increased, and the cost has increased year by year, and the investment in a new drug has reached nearly 1.8 billion US dollars.
So from the cost of drug research and development is indeed huge, the so-called unprofitable early, capital is profit-seeking, the cost is to be used for a thousand times the profit, so in the 20 years of the patent period, the price will certainly be set very very high, in contrast, generic drugs do not need to invest a lot of money for clinical research, research and development costs are much lower than the original research drugs, so the cost is much lower, plus the mainland medical insurance drug collection, and then the price continues to be pressed down, so the price of many drugs is as low as unimaginable.
From the perspective of efficacy, domestic generic drugs have passed the consistency evaluation, requiring domestic drugs and similar imported original drugs to maintain a high degree of consistency in pharmacodynamics and pharmacokinetics, to put it bluntly, there is no obvious difference.
At present, domestic aspirin, some manufacturers have passed the consistency evaluation, so even if the price is sold to 3 cents a piece, its quality and clinical effect are no different from the imported drugs of 7 yuan a piece, even if there is no manufacturer that has passed the consistency evaluation, due to the strict requirements of the state in the quality of drugs, this difference will not be too big. Therefore, patients can use domestic drugs with confidence.
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