When it comes to David Sinclair, the top of the anti-aging community, the outside world's impression of him is either a Harvard professor, a "godfather of anti-aging", or NMN, resveratrol and his scientific achievements. When Pai Pai introduced him before, he also mentioned that he founded an anti-aging company, but it was only a "related interest" that was gently taken.
But these two days of pie surfing, it was found that David Sinclair was not a man who could be summed up simply by saying "interested". According to incomplete statistics on the official website of the Sinclair Laboratory of Harvard Medical School (the last update was September 18, 2020), Sinclair actually has interests in nearly 50 companies.
Some of these 50 companies were founded by Sinclair, some of which he invested, some of whom he worked as a director or scientific advisor, and some of whom bought his patents, all of which are inextricably linked to him. The most outrageous thing is that in addition to anti-aging companies, this list actually includes agricultural and animal husbandry companies, and even companies that treat female infertility, which is so widely seen that the audience is amazing.
*The meaning of the letter after the company in the figure below:
F = Founder
I = Investor
E = Equity
A = Advisor /Consultant
B = Board of Directors
IP = Inventor on licensed patents
L = Funding for laboratory
Figure Note: Companies with sinclair interests
As the saying goes, look at a person not to see what he says, but to see what he does, and the same applies. Sinclair has a tolerant attitude towards various anti-aging technologies on podcasts and social media, and it seems that all roads can lead to anti-aging. However, a closer look at the long list above and which anti-aging companies he actually invested in or founded will give you a good idea of which anti-aging technologies he really favors.
Because there are too many related companies, here are only a few of the most representative ones for everyone to introduce the comments, like Sirtris Pharmaceuticals, which has become a company that has become history after pitting Glenschson 720 million US dollars ("Exclusive Decryption: The Chain of Interests Behind NMN Longevity Drug NR"), I will not repeat it here.
Invasion of the U.S. Special Operations Command,
Want to monopolize the NMN market
MetroBiotech, which specializes in the development of NAD+ precursors, claims to "change our lifestyle and aging through the pioneering NAD+ pharmaceuticals", and is one of the anti-aging companies co-founded by Sinclair.
The company's star product, "Super NAD+ Precursor" (synonymous Sinclair) MIB-626, is a special polycrystalline form of NMN, developed by Sinclair Laboratories, has entered Phase 2 human clinical, and is said to have a better effect than ordinary NMN products on the market.
Compared to other companies that Sinclair didn't mention, or branded once or twice on his Twitter, MetroBiotech and MIB-626 enjoy pro-son treatment here in Sinclair.
Sinclair first said in the podcast that "I am studying more effective (NMN supplements)", and then broke the principle of "not recommending NMN brands" and directly promoted the latest human clinical results of MIB-626 on Twitter: the safety and well-tolerated safety and well-tolerated of MIB-626 taken 1-2 times a day orally (Related Reading: "Is NMN!). "Godfather of Anti-Aging" Sinclair "Super NAD+" Human Clinical: Safe without Side Effects, or Monopoly on the Global Market").
Under Sinclair's support, MetroBiotech itself is also very competitive, and last June it "invaded" the US Special Operations Command, and reached a cooperation with the US Special Operations Command to carry out NAD+ anti-aging drug human clinical trials in fiscal 2022.
Last December, MetroBiotech also wrote a letter to the FDA, saying that its MIB-626 is a "patented form of NMN" that has been recognized as a drug, requiring the FDA to remove all NMN supplements from the market (Note: U.S. law stipulates that if a substance is approved by an official agency to recognize it as a drug, manufacturers can no longer sell the substance alone as a supplement or add to food). The FDA has not responded to the matter.
The road is winding,
The "money path" is bright
CohBar, a company that primarily uses naturally occurring mitochondrial peptide drugs to treat aging-related disorders associated with mitochondrial dysfunction. The founders of the company are mostly scientists from the field of anti-aging, including Professor Nir Barzilai, head of the first anti-aging human TAME in addition to Sinclair.
The company's most likely drug to market is CB4211, a natural mitochondrial-derived peptide MOTS-c analogue that can treat non-alcoholic steatohepatitis and obesity by modulating the AMPK pathway and/or insulin pathway, and has successfully completed 1a/1b clinical trials that show that CB4211 is not only curative, but also well tolerated, without serious adverse reactions. It is also currently the only mitochondrial-derived peptide drug that has completed human clinical trials.
In addition, CohBar has four other preclinical mitochondrial-derived peptide drugs for the treatment of diseases such as COVID-19, fibrotic disease, and cancer.
Note: CohBar drug progression
Mitochondria have always been an important research direction in the field of anti-aging, but there are not many anti-aging companies related to mitochondria, and CohBar can be said to be one of the leaders. But CohBar is still in its early clinical stages, with no path to profitability until CB4211 is expected to go public in 2025 and $10 million a year on research and development. However, analysts estimate that once CB4211 is successfully put into production, it will reach $240 million in annual sales.
So, while KohBar's road is tortuous, the road to money is bright, and Sinclair's investment vision is evident.
Every miller draws water to his own mill
The treatment is far better than that of the son
InsideTracker, a company focused on personalized nutrition and health analysis, uses patented big data algorithms, databases, and the latest scientific research results to provide personalized anti-aging guidance based on users' blood, DNA, and daily habits.
The company's second-generation flagship product, InnerAge 2.0, can reveal the user's physiological age by detecting biomarkers such as glucose and liver enzymes in the blood (18 for men and 14 for women) and provide a series of personalized improvement programs.
Of the companies associated with Sinclair, InsideTracker is arguably one of the most special. Sinclair once said on Twitter that he owned "a small number of InsiderTracker shares," but his efforts to promote it made people suspect that the company was owned by himself.
From his Twitter alone, the company's exposure is as high as dozens of times, go to insideTracker blood test to send a tweet, the test results come out to send a tweet, and even when someone leaves a message asking which indicators to detect, he also wants to cue InsideTracker, saying that he mainly tests here, which is the treatment that his son MetroBiotech does not have.
Figure Note: Someone left a message asking which indicators need to be detected, and the best way to detect them, Sinclair directly @InsideTracker
It's not surprising to think about Sinclair's preference for InsideTracker. Only by understanding their aging through testing can they know whether anti-aging interventions are effective, and it can be said that testing is the cornerstone of anti-aging. Sinclair himself loves to try new anti-aging methods, and in order to understand whether these anti-aging methods are effective or need to be adjusted, he has to do a blood test every quarter to understand his indicators in real time.
Anyway, to do the test, where is not to do, naturally the fertilizer water does not flow to the outsider field.
Cast wide nets and catch more fish
Life Biosciences is a longevity company founded by Sinclair focused on the pathology and basic biology of aging.
Unlike other companies that generally focus only on a specific area of aging, Life Biosciences has a larger spread outreach, covering almost all the major biological mechanisms related to aging and aging-related diseases, and currently mainly targets the three biological mechanisms of aging, protein homeostasis loss, mitochondrial dysfunction and epigenetic changes, most of which are still in the preclinical stage.
Note: Life Biosciences claims to develop drug discovery from the eight aging biological mechanisms mentioned above
Probably because there are too many aging molecular mechanisms, Life Biosciences itself is too busy to come, and it has acquired many subsidiaries to carry out research and development from different directions. For example, Life Biosciences' Senolytic Therapeutics, a company that, as its name suggests, treats aging and related diseases primarily through Senolytics therapy that removes senescent cells. Another subsidiary, Selphagy Therapeutics, focuses on autophagy and is currently developing autophagy drugs that can treat lysosomal storage disorder.
By the way, many of Life Biosciences' subsidiaries also have Sinclair's shadow, such as Senolytic Therapeutics, which Sinclair co-founded, and Animal Biosciences, which Sinclair invested in.
Overall, Sinclair is not as jumpy in terms of anti-aging investment as it is in interventions (such as the magical combination of 1/4 teaspoon of olive oil + resveratrol + matcha), but is rarely steady, investing in drugs developed according to anti-aging intervention mechanisms that have been widely recognized by the anti-aging community.
In a way, Sinclair, who founded and invested in multiple anti-aging companies, is more of a successful businessman than a pure scientist.
He once tweeted, "The mystery is not to make money but to be a scientist." If you know more than anyone, money will come unexpectedly. ”
Hopefully, under the constraint of many interests, Sinclair can really make money in the process of becoming a scientist, as he says, rather than playing a scientist to make money.
Sinclair's choice of InnerAge 2.0 quantifies aging by examining more than a dozen biomarkers in the blood. In contrast, the time ruler-Sanguine aging comprehensive blood test independently developed by Time Pie is no less impressive, covering 50 selection indicators, providing you with the same exclusive customized anti-aging guide of Sinclair.
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