Diabetic peripheral neuropathy is mainly due to the patient's body in a state of high blood sugar for a long time, resulting in damage to microvessels, which in turn leads to peripheral nerve tissue disorders. Most of the disease will cause nerve demyelinating damage, numbness, coldness, pain in the extremities, and an increased risk of complications such as infection and foot ulcers.
Studies believe that diabetic peripheral neuropathy is closely related to inflammatory response, injury, genetic factors, oxygen free radicals, etc. Western medicine treatment of diabetes mellitus with peripheral neuropathy is mainly symptomatic treatment, methylcobalamin, epastatic, lipoic acid as commonly used drugs, has a good improvement effect on the conduction of neurons, can repair damaged nerve tissue, but the efficacy is not ideal.
There is no distinction between type 1 diabetes and type 2 diabetes in traditional Chinese medicine, according to the symptoms and symptoms of diabetes, it belongs to the category of "thirst quenching", thirst quenching disease for a long time, gas consumption, blood injury, injury, qi and blood jin liquid are insufficient, qi deficiency blood stasis, jin liquid loss is the body lost in nourishment, the disease machine should be the basis of the virtual standard, and the key disease mechanism is qi deficiency blood stasis, and should be based on the method of beneficial qi and blood activation. Qidan tongluo granules, mutan granules, etc. are representative.
Qidan tongluo granules
Qidan Tongluo granules are composed of 12 herbs such as astragalus, danshen, angelica, appendage (system), guizhi, red peony, Sichuan root, Sichuan beef knee, fine spice, soil poria and Zhimu. It has the effect of invigorating blood, warming the sun, and relieving pain. It is suitable for the treatment of diabetic peripheral neuropathy, which is evidence of qi deficiency and blood stasis, cold coagulation, and is clinically manifested as spontaneous pain in the extremities, numbness in the extremities, chills in the extremities, weakness in the limbs, paresthesias or losses; or purple or dull tongue, fine or astringent pulses.
Fangzhong reuses astragalus and salvia, strengthens the power of yiqi and invigorates blood, assists with appendages, ephedra, fine spices, warm and helps yang, and penetrates the table, so that the evil qi comes out from the surface, so as to enhance the strength of Wenyang to disperse cold and relieve pain, which is the essence of the formula and the characteristics of the formula. In addition, take angelica blood replenishment, guizhi tonic liquid, jin blood homology, and play the work of replenishing blood together. Motherly cold moisturizing, both internal heat and thirst, bone steaming hot flashes. Poria is detoxified and dehumidified to increase the effect of tongli joints.
Modern pharmacological studies have shown that astragalus, salvia, angelica, Sichuan root, red peony and other blood-activating drugs, one can inhibit the activity of aldose reductase, with different degrees of hypoglycemic effect; the other is to inhibit platelet aggregation and improve microcirculation. In addition, Zhimu also has a strong inhibition of aldose reductase activity and significant hypoglycemic effect. The active ingredients in cinnamon, ephedra and fine spices have a certain analgesic effect.
The drug has a strong antioxidant effect, reduces the activity of aldose reductase, inhibits the accumulation of pathological products such as sorbitol and malondialdehyde in the nerve tissue, thereby improving the pathological changes of peripheral nerve demyelinating and improving the nerve conduction rate. At the same time, it also has a significant analgesic effect on the pain response caused by a variety of stimuli. It can effectively improve the symptoms of pain, numbness, paresthesia and other symptoms in patients with diabetic neuropathy, and improve the quality of life of patients.
Mudan granules
Mudan granules are composed of astragalus, yanhusuo (vinegar), panchi, red peony, salvia, Sichuan root, safflower, sumu, and chicken blood vine. It has the effect of invigorating qi and invigorating blood, and relieving pain. It is suitable for the treatment of diabetic peripheral neuropathy, which is a symptom of qi deficiency obstruction, and is clinically manifested as numbness, pain and paresthesia of the extremities and trunks; or skin nail errors, dull complexion, fatigue and fatigue, self-sweating, etc.
Studies have found that Mudan granules have a unique three-ring therapy: replenishing vitality, dissolving blood stasis, improving diabetic symptoms; removing blood stasis, restoring the elasticity of blood vessel walls, relieving pain; increasing blood flow, improving nerve conduction speed, and preventing disease recurrence. Among them, red peony, salvia, Sichuan root, safflower, sumu, chicken blood vine, etc. have obvious effects such as activating blood stasis and dredging meridians, which can increase local blood flow perfusion and establish lateral branch circulation, thereby effectively improving peripheral circulation and promoting the blood flow rate of lower limbs; it can also inhibit platelet aggregation and improve the tolerance of peripheral tissues to hypoxia.
In addition, salvia and hematoxylin can enhance the antioxidant capacity of microcirculation, reduce oxidative damage, and repair damaged nerves. Sanqi, Yanhusuo qi ventilation to relieve pain, has obvious analgesic effect, Yanhusuo can also sedative hypnosis. Chicken blood vine can antithrombin, improve hemodynamics, regulate immunity, anti-arteriosclerosis and so on.
The combination of mudan granules and methylcobalamin is significantly better than that of Western medicine alone. Numerous studies have shown that Mudan granules delay or reverse the occurrence and development of diabetic peripheral neuropathy by adjusting the comprehensive effects of affecting the level of neurometabolic substances, repairing damaged nerves, improving nerve conduction speed, relieving body pain symptoms and improving microcirculation.
In short, diabetic peripheral neuropathy as one of the common complications of diabetes, commonly used Western drugs are limited, mainly vitamin drugs such as methylcobalamin, lipoic acid, as an active coenzyme of neurometabolism, in the repair of nutrient nerves, promote nerve conduction and other aspects of the role, in addition to aldose reducta inhibitor epastat and so on. Qidan tongluo granules and mutan granules can achieve both symptoms and root causes through multi-component and multi-target action.