Human pursuit of immortality, from ancient times to the present has never stopped, there is a legend of Qin Shi Huang sent Xu Fu to seek immortal medicine, and with the continuous progress of scientific research, for anti-aging related research, has also been in progress, recently mainland scientists published in the Journal of Cell Discovery ("Cell Exploration") a new study, through a large number of experimental studies, revealed a common endogenous small molecule metabolite substance in the human body - uridine, with the ability to promote tissue regeneration, An important physiological role in enhancing individual physiology. Today's popular science article will introduce this major "anti-aging" discovery of mainland scientists and the magical substance of uridine.
Key metabolites for anti-aging were discovered
Severed limb regeneration, which exists in myths and legends of the "immortal skill", and for humans, it is impossible to do, but this ability, in the animal kingdom, there are many animals with such ability, salamander limbs are removed, can gradually regenerate, and in mammals, the antlers that fall off every year will also grow again, and in this newly published scientific research, scientists are through this cross-species metabolomics analysis and research, It was revealed that uridine may be an important metabolically critical substance that promotes tissue regeneration.
In this scientific research, scientists pointed out that stem cells occupy an important position in tissue repair and regeneration, if compared with the regenerative tissue stem cells of salamander limbs or deer antlers, human stem cells, mesenchymal stem cells, the regenerative repair ability of important tissues and organ damage is relatively limited, and with age, the repair ability of human stem cells will further decline or even lose, therefore, aging and disease production, and the above physiological mechanisms have an important relationship.
In order to study the differences in this metabolic substance that differs in the regenerative capacity of different species, the researchers studied the bud base of the regeneration of the broken limb of the salamander, deer antler stem cells, the brain, heart, liver, muscle, kidney and other tissues of young and old cynomolgus monkeys, and the mesenchymal stem cells of young and old people.
By analyzing metabolites with different regenerative capacities in different species models, after strict quality control and standardization, researchers identified 400 to 759 different types of metabolites in the model, including lipids, nucleotides, amino acids, carbohydrates, peptides, cofactors and vitamins, etc. After screening scientists, scientists found that uridine, a nucleotide substance, plays an important role in promoting human tissue repair and regeneration.
In vitro experimental studies have found that the stem cell model treated with uridine has higher regeneration and repair capacity, and achieves a higher proliferation rate and cartilage regeneration capacity, and obtains increased genomic and epigenomic stability. For in vivo experimental studies, the researchers selected uridine to conduct experimental studies on mice, and for mice with muscle injury models, pulmonary fibrosis models, hair regeneration models, myocardial infarction models and arthritis models, the mice were injected, smeared, orally, respectively, to allow the mice to further ingest uridine.
The results of animal experiments are gratifying! The results showed that uridine may promote tissue regeneration process by regulating metabolic processes and inhibiting inflammation, which has played a significant role in improving the repair and regeneration of the above tissues, and the mice in the uridine treatment group not only repaired the damaged tissue better, but also showed higher grip strength and longer running distance, and the researchers finally pointed out that through the above research, the filtered uridine is an effective compound that promotes the repair and regeneration of various tissues and organs, and has the potential to potentially improve the healthy life expectancy of the elderly.
What is the sacredness of uridine?
Many friends may not be familiar with the word uridine, in fact, this substance is a small molecule substance of origin in the human body, a nucleotide base substance that is very important to the human body, its full name is uracil nucleoside, which is a precursor substance of cell RNA synthesis, which is widely present in various organisms.
Physiological studies have proved that uridine has an important role in promoting the healthy formation of cell membranes, and this role is mainly derived from the fact that uridine is an important precursor substance for the synthesis of lecithin, and lecithin is not only an important substance constituting the cell membrane, but also an important nutrient for promoting the health of the nervous system. And improvement has been shown for a group of people with mild Alzheimer's (n = 221).
In the cross-species biological study conducted by Chinese scientists, the new functions of uridine were screened out, including the important role of anti-inflammatory, repairing tissue cell damage, promoting tissue regeneration, etc., and the systematic analysis of human mesenchymal stem cells in this study also found that uridine in the plasma of young individuals was higher than that in the plasma of the elderly. In Europe and the United States, in recent years, there have been exogenous supplementary uridine health care products on the market, and the US FDA also approved uridine drugs in 2016 to alleviate the adverse reactions of chemotherapy patients.
Uridine has such an important role, if you want exogenous supplementation of uridine, which foods contain this substance? In fact, in our daily familiar beer, breast milk, are rich in uridine, but breast milk is not accessible, and beer contains alcohol should not be drunk in large quantities, so these are not a good source of ingestion of uridine from the outside world, if you want to supplement uridine through diet, the following 3 types of food may wish to eat more in moderation -
Mushroom foods, including reishi mushrooms, are rich in uridine
Legumes, various legumes, and soy products are also rich in uridine.
Deep-sea fish meat is not only rich in uridine, but also rich in omega-3 fatty acids, and the two have the effect of synergistic nutrient nerves.
In addition, in broccoli, oats and other foods, are also rich in uridine.
Finally, it should be pointed out that uridine is a kind of "endogenous" small molecule substance in the human body, mainly derived from the body's autologous synthesis, through exogenous supplementation of uridine, can it play a role in promoting tissue repair, improving inflammatory response, delaying tissue and organ aging, and promoting healthy aging. Is exogenous supplementation a safety risk to the human body? Further scientific research is also needed, therefore, for these cutting-edge scientific research, what brings us is the light of hope to improve the quality of life and healthy life, and it is really applied to reality, and there is still a long way to go, so it is good to rationally look at the important role of uridine and pay attention to healthy diet supplements in daily life.
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