For patients who eat statins for a long time, the most disturbing is the "side effects of statins", while having to take drugs for a long time, while worrying about drugs hurting the liver, hurting the kidneys, and raising blood sugar... Therefore, in order to prevent these possible adverse reactions, everyone is also trying their best: reduce the dose of medication, take medicine every other day, add liver protection drugs and so on.
In fact, there is no need to be so troublesome, as long as you choose to treat him and eat him, you can still treat the disease without hurting the body.
Choose the intensity of the thorin
Statin is a class of lipid-adjusting drugs, it is mainly aimed at the primary target of lipid-regulating therapy is low-density lipoprotein cholesterol (LDL-C), including many kinds in the entire statin family, such as: pravastatin, fluvastatin, simvastatin, lovastatin, pitvastatin, atorvastatin, rosuvastatin... Their corresponding reduction in LDL cholesterol intensity is also different, and patients need to depend on their condition.
Various statins are divided into:
Low-intensity statin, daily dose reduction LDL-C<30%
20 mg lovastatin, 10 mg simvastatin, 20 mg pravastatin, 40 mg fluvastatin.
Medium-intensity statin, daily dose reduction LDL-C 30%-50%
40 mg or 80 mg lovastatin, 20 mg to 80 mg simvastatin, 40 mg or 80 mg pravastatin, 80 mg fluvastatin, 2 mg to 4 mg pitvastatin, 10 mg to 40 mg atorvastatin, 5 mg or 10 mg rosuvastatin.
High-intensity statin, daily dose reduction LDL-C≥50%
80 mg atorvastatin, 20 mg rosuvastatin
Statin treatment is not as intense and as fast as it drops, and high-intensity treatment doses increase the probability of adverse reactions at the same time. The study found that the incidence of adverse reactions in Chinese patients was 11 times that of patients in Europe and the United States. NLA guidelines recommend that statination be first of moderate intensity and that after lipids have reached control goals, they can be maintained at an initial dose based on close monitoring of lipids.
Choose the tanthin aging effect
In the past, doctors would emphasize to patients that statin should be eaten at night before going to bed, why are there fewer and fewer doctors saying so now? This is due to the fact that the half-life of the new generation of statins is getting longer and longer, and the third generation of long-acting statins: atorvastatin, rosuvastatin, and pitvastatin have a half-life of more than ten hours, whether eaten during the day or at night, the effect is not affected.
When choosing statin, it is also necessary to choose long-acting statin, which is not only convenient to eat, but also more sustainable and stable.
Match your own condition
All kinds of statins, various doses, the same medium intensity, pitvastatin only needs 2mg, and lovastatin, simvastatin, etc. can be used to 40mg, how to choose? Is it that the dose of 2mg is smaller, and the side effects are even smaller?
In fact, it cannot be compared in this way, various statins have their own characteristics, and they also need to match the appropriate statin according to their own physical conditions.
【Muscle soreness for what statin?】 】
Muscle pain, fatigue, severe patients will also have rhabdomyolysis. The highest risk of these myopathies is simvastatin, and patients with such adverse reactions may be considered switching to a long-acting statin or fluvastatin, which is at a lower risk of inducing myopathy.
【 What statin to change when blood sugar rises? 】
Long-term use of statins has an increased risk of new diabetes, atorvastatin, simvastatin has the highest risk, and the choice of pitvastatin and pravastatin has less interference with blood sugar.
【 What is the high uric acid for what statin? 】
Patients with hyperuricemia can choose atorvastatin when using statins, which promote renal uric acid excretion and thus reduce uric acid levels.
【 What statin to choose to affect sleep? 】
Simvastatin, lovastatin, atorvastatin, pitvastatin, these lipophilic statins are easy to cause central nervous system excitement, headache, insomnia, difficulty falling asleep, etc., patients with this problem can choose a long half-life, hydrolipidine bi-soluble statin under the guidance of a doctor, fluvastatin extended-release tablets, half-life can reach 9 hours, can be eaten in the morning, less impact on sleep.
Changing a lot of statins is not enough, how to lower fat?
For patients who have tried many statins and are still intolerant or have substandard blood lipids, PCSK9 inhibitors, cholesterol absorption inhibitors, bile acid, fibrates, or niacin drugs can be used under the guidance of a doctor. These lipid-lowering drugs, including the latest PCSK9 inhibitors, have also entered medicare this year, and patients need to take medication under the guidance of a doctor and monitor the effect and safety of the drug in the early stage of drug change.
In short, statin adverse reactions do not occur in everyone, when there are no discomfort symptoms, regular testing of blood lipids, liver and kidney function every year, you can rest assured of long-term use of statins. When there is an intolerance reaction, do not worry, statin so many types, with the doctor to choose the right drug for themselves, can also do the treatment without hurting the body.