Commonly used "local anesthetic" da cronin, how to deal with overdose with drugs?

*For medical professionals only

Clinical decision-making can be simpler

Dakronen is a commonly used local anesthetic in the clinic, but if overdose can cause cardiac arrest and convulsions. So, if a dacronin overdose occurs clinically, how should it be handled?

Treatment regimen for the occurrence of drug overdose

Prevention should be considered first, vital signs such as cardiovascular and respiratory should be continuously monitored after each local anesthesia, and the patient's state of consciousness should be confirmed at any time.

In the event of a drug overdose, the first step should be to control the convulsions and maintain airway patency, immediately oxygen-assisted or controlled ventilation, and provide a timely delivery system of positive airway pressure through a mask.

Immediately after ventilation, the patient is assessed for the adequacy of circulation, and convulsive drugs occasionally inhibit circulation when administered intravenously.

If persistent convulsions persist with adequate respiratory support, a small amount of ultra-short-acting barbiturates (e.g., thiopental or thiovalaldehyde) or benzodiazepines (e.g., diazepam) may be given intravenously, as the circulatory state permits.

Before using local anesthetics, clinicians should be familiar with the use of anticonvulsant drugs.

Supportive care with circulatory suppression may require intravenous fluids and the appropriate use of vasopressors (ephedrine) depending on the clinical situation. Without immediate treatment, both convulsions and cardiovascular depression can lead to hypoxia, acidosis, bradycardia, arrhythmias, and cardiac arrest.

If cardiac arrest occurs, standard CPR measures should be taken [1].

How to prevent drug overdose?

The right dosage, the right technical handling, adequate precautions and emergency preparedness are key to ensuring the safety and efficacy of dacronin medication.

To avoid high blood concentrations and serious adverse reactions, the lowest dose that can achieve effective anesthesia should be used.

Due to the slow accumulation of the drug or its metabolites, repeated administration of da cronin may lead to a significant increase in the concentration of the drug after each repeated administration.

Tolerance to higher blood concentrations will vary with the patient's status. Frail, elderly patients, patients with acute illness, and children should reduce the dose according to their age, weight, and physical condition.

Patients with severe shock or heart block should also use dacronin with caution [1].

Resources:

[1] Product Information: DYCLOPRO-dyclonine hydrochloride solution,Septodont Inc.January 7,2020

This article was first published: Clinical Pharmacy Channel of the Medical Community

Author: Jie Xiao Yao

Editor-in-Charge: Little Dangdang

More good articles on clinical medication

Follow the Clinical Pharmacy Channel to view

*The copyright of this article belongs to the original author, if you need to reprint, please contact the original author for authorization