Do you know how many gout patients there are in our country? Relevant data surveys show that the prevalence of gout in China has increased to about 1 to 3%, on average, 1-3 people in 100 people are plagued by gout diseases, the total number of patients has reached nearly 75 million, and this data is growing at a rate of 9.7% per year, gout has become the most common and complex type of arthritis.
According to the data available to the clinic, the essence of gout is crystal sedimentary arthritis, and the basis of its disease is hyperuricemia. The bin causes that trace the emergence of hyperuricemia include genetic genes, age and gender, poor living and eating habits, etc., which eventually lead to imbalances in purine production and metabolism, and hyperuricemia breaks out;
Due to the serious overste of the patient's blood uric acid level, a large number of urate crystals precipitated and accumulated in the joints, which eventually caused a sudden onset of acute gout, and the joints appeared red, swollen, hot and painful, and the pain was deep, and the patients were often unbearable. Moreover, the vast majority of gout patients first onset in the middle of the night, and suddenly there is abnormal pain in the big toe joint.
This makes people wonder why gout prefers the night, and what is the secret in this?
1. Corticosteroid secretion
The basic role of corticosteroids in the body is to fight various inflammatory reactions in the body, play an immune role and relieve pain. However, the secretion of hormones in the human body is also regular, and after entering a state of sleep, the amount of corticosteroid secretion in the body will gradually decrease, resulting in a sudden onset of gout;
2. The effect of hypoxia
Purines are divided into two categories: endogenous and exogenous, that is, even if the human body does not ingest foods containing purines, it will secrete purines internally. Studies have shown that frequent lack of oxygen prompts the body to produce more purines, and the terminal metabolite of purines is uric acid.
When entering the sleep state at night, especially in patients with sleep apnea syndrome, it is easy to have symptoms of apnea and hypoxia, which undoubtedly leaves a breakthrough for gout;
3. Temperature effect
The reason why gout appears more often on the small joints at the time of the initial onset is because urate crystals have certain requirements for temperature, and they prefer a low temperature environment, so it is easier to deposit at the joints with weak skin coverage.
The ambient temperature at night itself is relatively low, affected by inactivity, body temperature will also decline, blood vessels constrict, more diuretic crystal precipitation, and then cause gout bursts;
4. Moisture
In the process of sleep, people do not obtain water through diet, but the water in the body is consumed, such as urination, breathing and sweating at night, which will lead to a lot of water loss. Blood uric acid levels can therefore be elevated, leading to gout attacks.
Because of this, it is also recommended that patients with high uric acid need to supplement more water every day, and at least 1500-3000ml of water should be ingested every day to meet the basic needs of the body and uric acid metabolism.
Written at the end: Gout attacks at night, which is the result of a multi-factor combination, which is mainly related to the above four causes. In addition, if you eat a lot of purine-containing foods at night, such as animal offal, seafood and beer.
Blood uric acid levels can rise rapidly as a result, leading to gout attacks. In the clinic, most patients with gout have a sudden attack after an alcohol attack. Once gout appears, patients need to actively seek medical treatment for anti-inflammatory and analgesic treatment.