Antibacterial elixir - nerofloxacin malate, can anyone eat it? Can people with poor liver and kidney function eat it? Do other drugs and foods have an effect on it? Are there few adverse reactions to this drug?

Author: Li Ying, chief pharmacist of the General Hospital of the Northern Theater

Neroxacin malate, is a new type of fluoroquinolone-free drugs, its antibacterial spectrum is wider, gram-negative bacteria, gram-positive bacteria, anaerobic bacteria and atypical pathogens have antibacterial effect, the effect on sensitive bacteria has been enhanced, especially for respiratory tract infections, has a strong antibacterial activity. After its listing, it has been widely used in clinical practice and has gradually become a first-line drug for community-acquired pneumonia. But not everyone is suitable, and like other quinolones, nerofloxacin malate still has a lot of precautions to pay attention to.

<h1 class="pgc-h-arrow-right" data-track="4" can people with poor liver and kidney function eat it >? </h1>

The liver and kidney function of patients has a greater impact on the metabolism of drugs, which in turn affects the therapeutic effect of drugs and produces side effects. Nenoxacin malate for patients with mild liver and kidney dysfunction and the elderly, the instructions do not require it to adjust the dose, but for severe liver and kidney insufficiency, there is no specific clinical research data, which means that when using drugs, as medical staff, we must first ask the patient's liver and kidney function, and in the process of use, the patient should also be regularly checked, always pay attention to the changes in liver and kidney function.

<h1 class="pgc-h-arrow-right" data-track="22" > do other drugs and foods have an effect on it? </h1>

This drug may interact with chelating agents, so when combined with antacids, aluminum, metal cations, and iron agents, the interval should be more than 2 hours. When combined with anti-sugar drugs, it may cause blood glucose disorders, and patients with diabetes should pay attention to observing blood glucose changes. Calcium and food have less effect on this drug and can be adjusted without dose adjustment. Because quinolones are easy to cause crystallization and cast urine, it is also recommended to drink more water during the period of taking this drug to prevent high concentrations of urine, which in turn affects kidney function.

<h1 class="pgc-h-arrow-right" data-track="24" > there are few adverse reactions to this drug? </h1>

As a new drug, compared to other quinolones, the adverse reactions of nerofloxacin malate are indeed much less. In recent years, adverse reactions to quinolones have been reported one after another, including serious and important adverse events, especially fluorine-containing quinolones. Adverse reactions have been reported including tendon rupture in tendonitis, worsening of myasthenia gravis, severe allergic reactions, hepatotoxicity, effects on the central nervous system, pseudomembranous colitis, peripheral neuropathy, prolongation of the QT interval, blood glucose disorders, photosensitivity reactions, drug resistance, etc.

In clinical trials of nairofloxacin, although the average QT interval prolongation is shorter than that of moxifloxacin, it will still cause QT interval prolongation, so when using the drug, pay special attention to changes in heart rate and heart function. In addition to the QT interval prolongation, for the fluorine-free neroxacin malate, there are no adverse reaction events at present, but the cause of adverse reactions may not only be fluoride ions, but also may be some other drug structures, and even the entire quinolone drug structure, therefore, in the process of use, we can not relax our vigilance, the occurrence of adverse reactions, should pay attention to observation, to avoid serious drug harmful events.

The emergence of new drugs represents the development and progress of the medical industry and is our new weapon against disease, but at the same time, this weapon is also a double-edged sword, and only by monitoring the therapeutic effect and adverse reactions of drugs can we give the most comprehensive guarantee of life.

Review experts: Zhao Qingchun, chief pharmacist of the General Hospital of the Northern Theater, and Sun Xue, deputy chief pharmacist

The above is the original work of the volunteers of the "Drug Safety Cooperation Alliance", if you reprint, please indicate the author and source!

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