From ancient times to the present, human beings have never given up the pursuit of longevity. If the anecdotes of ancient times represent the human yearning for longevity, then the breakthroughs of scientists in this regard now mean that some of people's fantasies are gradually becoming reality.
In recent years, scientists have made frequent success stories in related fields, such as the discovery that young blood in the human body may contain a special component that can make the physiological age of elderly tissues appear smaller.
1 New discoveries in "Young Blood"
As early as a decade ago, the well-known academic journal "Nature" published a study at Stanford University: researchers cut the sides of twilight mice and young mice, and connected their vascular circulatory systems. Prior to this, the problem of immune rejection had been ruled out. It was found that the ages of the two mice were "wiped out", the hair of the twilight mice became brighter, and the young mice looked sluggish.
The study kicked off the study of young blood, and scientists have made breakthroughs in recent years. In May 2020, the University of California, Steve Hovat research team posted that they used six 109-week (middle-aged) mice for experiments, and after receiving 8 young plasma injections for 155 days, their tissue average physiological age was reversed by 54%, equivalent to a human regression from 50 to 25 years old.
After the blood exchange operation, the fat of the twilight mice decreased a lot, and the blood indicators related to aging appeared more obviously younger, and the functions such as the heart even caught up with the young mice, and the exercise and cognitive ability were also greatly improved. After re-testing, it was found that the experiment improved the senescent cells, reactive oxygen species, etc. of the twilight mice, making these indicators almost indistinguishable from young mice.
Recently, the sub-journal "Nature" elaborated in more detail on the mechanism of action of "young blood to elongate life", proposing that extracellular vesicles in the blood are crucial, and they carry "longevity protein" to various parts of the body for synthesis. Aging affects the stability of extracellular vesicles, making it difficult to achieve self-healing.
2 The carnival of the rich, "young blood" makes them excited
The study of young blood soon spread to the ears of many foreign rich people, who were very excited. Foreign media Gawker once pointed out that PayPal co-founder Thiel has spent tens of thousands of dollars every quarter to obtain young blood from 18-year-olds, so it has become the prototype of the character in the film and television drama "Silicon Valley". In fact, such a transaction has even developed into an industry in the local area, and the American Ambrosia company even sells young blood as mineral water for $8,000, and it is reported that more than a thousand registered rich merchants have purchased it.
According to public information, Russian bioscientists have even conducted more daring experiments, they have pumped half of their blood, and they want to return themselves to a younger state by reducing the blood concentration of aging. One of the participants said that after a few maneuvers, his morning energy had gotten better and he had been holding it for a few days, and he enjoyed the feeling.
These attempts by the rich and biotechnologists have also attracted the attention of the US FDA, who said that this method may be risky and should be paid attention to its adverse effects, otherwise it will be punished. What is intriguing is that similar substances such as NAD and metformin have been licensed by the FDA, and the NAD finished products represented by the biotechnology company LiteViken "Wlnad" have empowered the cellular mitochondria by synthesizing the corresponding coenzyme substances, playing a similar benefit of "reversing the life clock".
Scientists have found that adhering to the intake of DIRECT PRECURSORs of NAD can increase insulin resistance in diabetic mice, and improve some physiological manifestations such as the degree of mitochondrial activation and the correct expression of genes to a better state, making them comparable to young mice. Based on the human experiments represented by the University of Washington this year, it can be seen that the substance can also achieve similar results in the human body, which makes "Wlnad" after being introduced into China and being sought after by a large number of high-net-worth people in the Eastern Circle. The industry has made a prejudgment of the field in which LiteVisgen is located, believing that the relevant market may reach a scale of 100 billion yuan in 3 years.
3 The study of blood exchange is still deepening, and science has no end
Compared with relatively mature technologies, the study of blood exchange is more controversial, but scientists are also conducting more convincing experiments based on mouse experiments. On the basis of the above, American scientists have found that blood exchange therapy can reduce the brain damage caused by stroke; and the University of California research team has come to the conclusion after 8 blood exchange experiments: after 90 days of symbiosis in allogeneic mice of different ages, it was found that the liver and blood age of twilight mice were reversed by up to 26% and 28%, respectively.
Similar to the advent of more and more scientific research results and the popularization of related knowledge, the industry is more optimistic about the future life expectancy of human beings. Scientists even believe that children born after 2010 have a high chance of reaching the threshold of 100 years old, when there will be more convincing and more mature scientific and technological means to replace old technology, and the number of human survival years may be further increased.