On December 14, Paris Saint-Germain drew Real Madrid in the Champions League round of 16, and Messi will once again face his old rivals.

During his time at Barcelona, Messi played 45 games against Real Madrid, achieving a record of 19 wins, 11 draws and 15 defeats, scoring 26 goals and providing 14 assists.
In April 2017, Messi scored a second-time tie at the Bernabeu to help Barcelona beat their opponents 3-2, and the way he celebrated his shirt at the Bernabeu became a classic.