Regarding the problem of long-term use of antihypertensive drugs causing cancer and not causing cancer, although it has been popularized many times for everyone, there are still many fan messages: I heard that Puly antihypertensive drugs can cause cancer, do I want to stop the drug? I heard that sartan-type antihypertensive drugs contain carcinogens, do I want to change them? In this era of fast information dissemination and wide dissemination, all kinds of information are coming at the surface, how to maintain rationality, reasonable identification of authenticity is particularly important, but some information in order to attract people's attention, earn traffic, choose to exaggerate and distort the facts, resulting in the audience's cognitive misunderstanding of the basic facts, and even cause some people to panic, especially in the field of health science, such a practice is extremely undesirable.
In recent years, information about the carcinogenicity of puly and sartan antihypertensive drugs has been spreading, so will these two types of drugs be really carcinogenic for a long time? Let's briefly introduce the source of this kind of news, and then we will slowly analyze it.
The claim that prly antihypertensives cause cancer comes from a large clinical study in Canada that found that patients with hypertension who took pry antihypertensive drugs were more likely to develop lung cancer than those who took sartan-like antihypertensives. After the publication of this study, it has aroused the doubts of many clinical experts, and there are also many large clinical studies that prove that long-term use of pry antihypertensive drugs does not increase the risk of carcinogenesis, so it is not scientific to think that long-term use of pry antihypertensive drugs will cause cancer through such a single study.
The sartan antihypertensive drugs carcinogenicity, is from the drug may exist in the carcinogenic impurity risk, on this point, the European Drug Quality Administration has twice issued an announcement, the presence of nitroso compound impurities and azide impurities in the sartan class drugs put forward a warning, in the synthesis process of some satan drugs, there may indeed be a risk of producing the above carcinogenic impurities, but with the increasingly strict supervision and the continuous improvement of drug quality control means, the current related sartan APIs, The removal and monitoring of the above impurities have also been strengthened in the production process, so the risk of carcinogenicity caused by impurities exceeding the standard is also relatively small.
For the above kind of statement, Professor Hu Dayi, an expert in cardiovascular diseases in China and director of the Cardiovascular Research Institute of Peking University People's Hospital, pointed out that commonly used antihypertensive drugs do not cause cancer. For the majority of hypertensive patients often use ACE inhibitor drugs (such as captopril, enalapril, pedopril, benazepril, ramipril, etc.), as well as angiotensin receptor antagonists (such as losartan, valsartan, irbesartan, telmisartan, candesartan, olmesartan, etc.), and even in the horizon antihypertensive drugs, the so-called "carcinogenic risk" is pseudoscientific information. And the spread of this pseudo-scientific information, in our country's many hypertensive patients, will cause great confusion and confusion, if hypertension patients because of listening to these misleading false information, do not dare to use or stop the relevant antihypertensive drugs, can continue to be used to control blood pressure antihypertensive drug choice will go to a dead end, resulting in only a small number of antihypertensive drugs available, the spread of such pseudo-scientific information, is really harmful!
Many friends themselves have a certain resistance to long-term medication, worried that long-term medication brings some unnecessary adverse reaction risks, and after reading some reports of antihypertensive drugs causing cancer, they are even more afraid or unwilling to take drugs, in fact, long-term use of antihypertensive drugs is really carcinogenic? We put aside the data of relevant studies, from the development of the research level of medical technology and the continuous improvement of the level of drug supervision, the cancer risk of long-term use of antihypertensive drugs is also extremely low.
Our research and cognition of drugs, is also in the process of continuous development and updating, take antihypertensive drugs, in the middle of the last century, or diuretics and hemoetic parity central nervous system antihypertensive drugs in the world, and in the 80s of the last century, the horizon antihypertensive drugs began to be listed, Puly antihypertensive drugs in the 90s began to become a clinical first-line drug, and the wide application of sartan drugs is even later, and from the drug quality control is the same, with the continuous deepening of people's research and understanding of drug impurities, And the continuous improvement of drug production process control and detection methods, the current research on the relevant carcinogenic impurities of drugs, or relatively in-depth, and for a variety of carcinogens, there are also high-sensitivity detection methods for strict control, therefore, compared with the past, the purity and safety of the antihypertensive drugs we currently take are getting higher and higher, which is the inevitable result of social development progress, for some commonly used antihypertensive drugs The so-called carcinogenic risks, there is no need to worry too much.
In terms of drug supervision, countries now have a strict post-marketing adverse reaction monitoring system, which will respond and feedback in a timely manner to the clinical safety problems that may occur in drugs, and for some drugs with greater risks, the drug regulatory authorities will promptly put forward recall or withdrawal requirements. Puli class antihypertensive drugs, sartan antihypertensive drugs, in clinical application are more than 20 years of history, more than 20 years of time to verify the clinical efficacy and safety of drugs, if there is a wide range of carcinogenic risks, such drugs are impossible to continue to use clinically, therefore, we instead of looking at a single study, or a recall event, it is better to combine the clinical application history of the drug itself to think for themselves, the current clinical commonly used Puly, sartan antihypertensive drugs, long-term use will not increase cancer risk.
In China, every 10 adults in 3 hypertension patients, stroke, ischemic heart disease in the top two of the disease death, the high incidence of these two diseases and high fatality rate, and the high proportion of hypertensive population, low hypertension control rate has a close relationship, therefore, for friends with hypertension problems, only actively control blood pressure, improve blood pressure compliance rate, ensure long-term stability of blood pressure standards, in order to better reduce the risk of cardiovascular and cerebrovascular diseases brought by hypertension and kidney and other targeted organ damage, And most of the hypertensive patients, want to control blood pressure to the standard range, in the good life conditioning at the same time, need to add antihypertensive drugs to strengthen blood pressure control, if because of listening to some rumors or exaggerated facts, and stop or dare not use antihypertensive drugs, the cardiovascular and cerebrovascular risk will inevitably increase significantly, the risk and benefit of these two are greater and smaller, I believe that everyone can clearly get the answer by reading this popular science article, and actively do a good job in stable control of blood pressure.