Recently Xiao Miao received a private message from a fan, she said in the letter that she is a girl, but also love beauty, but the blackhead on the nose has plagued her for many years, recently in the subway station saw a lot of ads about metronidazole gel, said that it can treat blackheads, so she decisively ordered, smeared for more than a week, it did work quickly, blackheads disappeared a lot, but then continue to use there is no effect.
Call to ask customer service, customer service said that the drug may have entered the bottleneck period, continue to use the words can be solved, I also obeyed, but now the blackhead not only did not improve, but the skin became very sensitive, what is going on?
To know if we can continue to use it, we must first understand what metronidazole is.
From the discovery of metronidazole in the 1950s to 1963, when it was approved for use in the United States, its role has been widely discussed, but its true identity is well known.
In the 1950s, scientists discovered metronidazole from Streptomyces, a synthetic derivative of azopenicillin, in other words metronidazole is actually a type of antibiotic.
At first, metronidazole was used to treat vaginitis, inadvertently found that it can treat gingivitis, and later with the development of medicine, metronidazole as an antibiotic, the nitro group it carries has a strong reducivity, which can produce a metabolite with anti-anaerobic bacteria under the reducing effect of the human body, not only can interfere with the growth and reproduction of bacteria by inhibiting the synthesis of bacterial deoxynucleotides, but also eventually lead to bacterial death, and finally proved to have a better effect on anaerobic bacteria, so it is mainly used for anti-anaerobic treatment.
Explain what metronidazole is, so let's talk about whether metronidazole can treat blackheads.
In the mouths of bloggers on major platforms, "metronidazole" is often worshipped as a blackhead artifact. But in fact, metronidazole has little effect on blackheads.
We know that metronidazole is used for the local treatment of inflammatory papules, impetigo, rosacea, but blackheads do not have inflammation, generally caused by oil secretion and external dust blocking pores, so metronidazole does not work. The reason why many people believe that metronidazole is effective against blackheads is because metronidazole gel has a high water content, and the keratin softens after soaking, relaxing the restraints on blackheads, and blackheads are easier to clean out.
Compared with other blackhead products, metronidazole gel is much worse, and because metronidazole is an antibiotic, it is easy to have side effects on the human body when used more, so it cannot be used for a long time, so it is not recommended. If you want to go to blackheads, choose drugs that target blackheads, such as tretinoins.
Since metronidazole has no effect on blackheads, what disease can metronidazole, which is highly sought after by the public, cure?
1. Gynecological surgery
In gynecological diseases, female reproductive organs are often plagued by itching and pain due to partial exposure, and metronidazole can play a role. Various gynecological diseases such as pudendal pruritus, genital eczema, vulvar leukoplakia and acute female vulvar ulcers are mostly caused by anaerobic bacteria, so metronidazole can be effective in preventing infection before and after surgery.
2. Peptic ulcer
Various findings have suggested that peptic ulcers are closely linked to Campylobacter pylori. Campylobacter pylori is an anaerobic bacterium that kills metronidazole, inhibits gastric acid secretion, and promotes wound healing of ulcers.
3. Pelvic infection
In daily life, many women often have severe pain in the lower abdomen, especially around the time of menstruation, which is likely to be pelvic inflammatory disease. For the treatment of pelvic inflammation, mainly anti-inflammatory, with metronidazole, to avoid infection. In the case of pelvic infection, the cure rate can be as high as 85% if metronidazole is combined with other antibiotics.
4. Brain abscess and pleurisy
When the body's brain parenchyma is invaded by pathogens such as bacteria and fungi from the outside world, and because it causes purulent inflammation and subsequent symptoms, this causes brain abscesses and pleurisy. According to the different sources of infection, brain abscesses can be divided into 5 categories: ear-derived brain abscesses, nasal brain abscesses, blood-borne brain abscesses and cryptogenic brain abscesses, which are surgically drained and injected with antibiotics in the pus cavity and supplemented with metronidazole to fight against anaerobic bacteria, and penicillin to resist aerobic bacteria.
5. Abdominal infection
Intra-abdominal diseases are prone to sepsis, as well as sepsis, sepsis, septic arthritis caused by anaerobic bacteria, etc., using metronidazole in combination with other antibiotics, and its therapeutic effect can reach the ideal level.
Metronidazole as an antibiotic, easy to use is easy to use, but its own side effects can not be underestimated, such as digestive tract diseases, toxic encephalopathy, arrhythmias and so on will make patients headaches.
Metronidazole is a drug that stimulates the gastrointestinal tract relatively largely, which can lead to nausea, vomiting, loss of appetite, abdominal cramps and other phenomena. In general, patients taking it on an empty stomach is more likely to cause this symptom, it is recommended to choose to take it after meals, or it can also be combined with taking sucralfate to alleviate stomach irritation.
As for toxic encephalopathy, due to the principle of metronidazole causing the disease, the medical community has not been able to give a definitive answer, and it is currently known that it may be related to cytotoxic edema or mitochondrial dysfunction. Toxic encephalopathy can affect the cerebellar system, causing patients to develop symptoms such as vertigo, nystagmus, and ataxia.
Patients taking metronidazole also have arrhythmias and other phenomena, and may often be accompanied by symptoms such as dizziness, fatigue, and shortness of breath.
First of all, we must recognize that metronidazole is not effective in removing blackheads, please find other effective prescriptions to remove blackheads. Secondly, metronidazole is an antibiotic, and the side effects of blindly taking and taking too much should not be underestimated. Therefore, the most important thing is to follow the doctor's instructions and take the appropriate drugs scientifically.
Resources: 1. Clinical analysis of lactobacilli combined with metronidazole in the treatment of pregnancy with trichomoniasis vaginitis. Chinese Sex Science, January 2016 2. Analysis of adverse reactions of metronidazole at home and abroad. Chinese Journal of Hospital Infectious Diseases 3. Research Progress on metabolism of nitroimidazole drugs in humans. Chinese Pharmaceutical Journal. July 2015
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