According to the New York Post reporter Brian Lewis, the 2022 NBA All-Star Game will be held in Cleveland, and there is no local epidemic prevention regulation similar to New York, if Irving is selected as an All-Star, he can play in this game. According to multiple sources, Irving will be on the 2022 All-Star candidate list and will be allowed to play.
If Irving insists on not getting vaccinated, the All-Stars will be Irving's only game of the season.