What sugar is it? - Isomerized lactose.
Isomerized lactose is the name used on the food additive manual gb2760.
Isomerized lactose has several names, also known as lactose, or lactulose.
Lactulose is the most well-known name in the pharmacopoeia.
Researchers who study oligosaccharides are accustomed to calling lactose.
The raw material of isomerized lactose is lactose isolated from milk – lactose is a disaccharide composed of galactose and glucose.
Lactose undergoes isomerization reaction under the action of lye and catalyst, and then after a series of processes such as separation and purification, isomerized lactose is obtained.
Isomerized lactose is also a disaccharide, composed of galactose and fructose, so it is also called lactulose.
1. Isomerized lactose will not be metabolized by oral microorganisms, so it will not cause caries;
2, it can not be hydrolyzed by enzymes in the small intestine, so it can not be digested and absorbed by the human body, and it will not cause fluctuations in blood sugar levels after eating, so although it is called "sugar", it is also suitable for diabetics to eat.
So what is the effect of isomerized lactose on the human body? It can directly reach the human large intestine and become food for beneficial bacteria in the intestine, such as bifidobacteria and lactobacillus in the large intestine, so that these bacteria can proliferate.
Therefore, isomerized lactose is a prebiotic, but also a prebiotic with a certain degree of sweetness (not all prebiotics are sweet).
Prebiotics are substances that can be selectively utilized by the flora in the host body and converted into substances that benefit the health of the host.
—— International Association of Probiotics and Prebiotic Sciences (ISAPP) Isomerized Lactose - Care for Infant Intestinal Health
Bifidobacterium is a typical representative of beneficial bacteria, and in the intestinal flora of breastfed infants, the content of bifidobacteria is higher, reaching 92.2%. In addition, in breastfed infants, the lysozyme activity measured in the baby's feces is also high (lysozyme has antibacterial, anti-inflammatory, antiviral and other effects), which is one of the manifestations of the baby's intestinal health.
Principle: Lysozyme is more sensitive to phH, when the ph value in the intestine is greater than 6.0, lysozyme will lose its activity, and isomerized lactose through the proliferation of probiotics, reduce the intestinal pH, stimulate a large number of lysozyme production, and increase its activity.
In the intestines of artificially fed infants, the proportion of bifidobacteria is only about 19%, and the proportion of E. coli (conditionally pathogenic bacteria) accounts for 24.4%.
However, after supplementing artificially fed infants with a certain amount of isomerized lactose, the situation changed, and after 24-96 hours, there was a significant increase in bifidobacteria in the infant's intestine. At the same time, the lactic acid and acetic acid metabolized by these bacteria greatly reduce the intestinal pH, and the intestinal pH decreases, which can inhibit the growth of putrefaction bacteria in the intestine, maintain the health of the intestinal wall, reduce the permeability of the intestinal wall, reduce the absorption of endotoxins into the blood, thereby maintaining good health.
Therefore, for artificially fed infants, adding an appropriate amount of isomerized lactose to infant food is of great significance to the health of infants.
In China's "Food Additives Use Standard" - gb2760, isomerized lactose liquid is indeed recommended for infant formula food and special medical formula food.
Isomerized lactose - "detoxification" of patients with liver disease
As mentioned earlier, in the pharmacopoeia, the name of isomerized lactose is lactulose, which is often used in the rehabilitation of patients with liver disease.
Because patients with liver disease, especially patients with cirrhosis, the microflora in the digestive tract is imbalanced, and accompanied by hyperammonemia, and after ingestion of lactulose, the intestinal flora is restored to balance, beneficial bacteria are increased, and the short-chain fatty acids metabolized reduce the intestinal pH, and most of the ammonia is present in ammonia ions, and ammonia ions are not easily absorbed by the human body. In the acidic environment, the balance of nonionic ammonia and ionic ammonia changes, which can transfer the ammonia in the blood to the large intestine and excrete it from the body, thereby reducing the content of blood ammonia and greatly slowing down the occurrence of hepatic encephalopathy.
As a two-molecule sugar, lactulose has a higher osmotic pressure, under the action of osmotic pressure, water molecules penetrate into the intestine from the intestinal cell wall, and the human body will have a "light diarrhea" effect, excreting ammonia and other toxic substances in the intestine, while also reducing their production.
Isomerized lactose – diabetic-friendly
The study of the gut microbiota is increasingly revealing that the cause of type II diabetes and obesity is an imbalance in the gut microbiota.
In the case of diabetes, for example, imbalances in the gut of harmful bacteria (such as Enterobacter gustosis, which we found in Fiber), cause insulin resistance. It is precisely because the human body produces insulin resistance, so that the human body digests the same amount of digestible carbohydrates, needs to secrete more insulin, and even makes insulin can not play a role in digestible sugars, the pancreas is in a state of overload operation, and can not be digested digestible carbohydrates, the high osmolality produced by the kidneys and a series of other damage.
For people with diabetes:
1, isomerized lactose has a certain degree of sweetness, so it can replace sucrose as a sweetener;
2, it can not be decomposed by human digestive enzymes, so it will not cause blood sugar fluctuations;
3, isomerized lactose in the proliferation of beneficial bacteria at the same time, can greatly reduce the number of harmful bacteria, these harmful bacteria, some of these harmful bacteria are related bacteria that induce insulin resistance, so it can effectively eliminate the insulin resistance of diabetic people and alleviate the pancreatic load;
4. The short-chain fatty acids secreted by beneficial bacteria can maintain the health of the intestinal wall, greatly reduce the permeability of the intestinal wall, reduce the endotoxin into the blood, reduce the inflammation of the body system, postpone the occurrence of complications, and improve the quality of life of diabetics.
Isomer lactose – a boon for patients with long-term constipation
In pharmaceutical and functional foods, isomerized lactose and a small amount of insoluble dietary fiber work together to effectively treat patients with long-term constipation.
Isomerized lactose – expensive
Isomerized lactose can be safely used in infant formula, and in the "Food Additive Use Standard" gb2760, the scope of approved use is also relatively wide. However, there are not many foods that use isomerized lactose in the current commercial products, because it is really expensive.
Lactose isolated from milk, itself is more expensive than corn, chicory and other raw materials, the production process, raw materials and target products, are bimolecular sugar, separation and purification difficulty is relatively high, so the price of isomerized lactose is ten times or dozens of times the unit price of ordinary oligosaccharides, so it limits its application.
Expensive is really expensive, and the effect is really good.
So we still added isomerized lactose to the compound prebiotics.
Our compound prebiotics use research methods for intestinal microbiota gene sequencing, and after rigorous scientific animal experiments, focus on nutritional intervention formulas aimed at eliminating disorders of glycolipid metabolism. In the course of the experiment, after the study of the complex human intestinal flora, the appropriate intervention factors were screened out to determine the appropriate and safe dosage for the human body. Isomerized lactose plays an important role as an important component of this.
Prebiotics are non-digestible food ingredients that improve host health by selectively stimulating the growth and activity of bacteria in one or a few colonies (gibson and roberfroid, 1995).