1. Hemostasis The results of modern pharmacological studies have not yet determined whether hemorrhage can be stopped. It has been reported that after intravenous injection of crane herb in mice, the bleeding time was shortened by 45%.Giving 104 rabbits intravenously 2mg/kg of sodium salt of crane grass could increase the number of platelets, increase serum calcium content and shorten the clotting time. It is made of crane herb as a powder for bleeding from trauma, bleeding or bleeding during visceral surgery, and has a definite effect. It has also been reported that the infusion of the product and the injection of crane grass, regardless of in vitro or in vivo experiments, have not promoted hemagglutination. The product contains A, B, C and another phenolic tarpine contained in this product, which have no pro-hemagglutination effect.
2. Antibacterial and anti-inflammatory effects Experiments have proved that the hot water or ethanol infusion of Xianhe grass has inhibitory effect on Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus aureus, Bacillus dysentery and Bacillus typhoid fever in the test tube, and also has inhibitory effect on Humanoid Tuberculosis Bacillus. Whole grass aqueous extract and aqueous-alcohol extract have anti-inflammatory effects on rabbit conjunctivitis caused by mustard oil or staphylococcal infection, which is related to the tannin containing condensed tannin (Phlobaphene) in xianhe grass.
3. Insecticidal effectSophallin has a definite insecticidal effect on pork tapeworm cysticercoccystis, larvae, Tapeworm Mohs and Taenia brachycephalus. The rate of taenin is much faster than that of taenole. Experiments have shown that the repellent effect of crane oxalol is not through the nervous system, but through direct contact with the entire insect body. Whether it is a head-neck chain, a gestational egg chain or any segment of the worm body, all parts that come into contact with crane hydroxol produce contractures and die, and the parts that do not come into contact with the liquid medicine survive as usual. It has been reported that after the whole worm or ex vivo segment of Tapeworm Mohs is blocked by the "choline receptor" of the worm body with atropine, the effect of acetylcholine can be blocked by atropine, but does not affect the effect of crane phenol on the insect body, which indicates that the direct contact effect of crane grass phenol on the insect body may not be through the choline receptor. Experiments have shown that crane phenol can inhibit glycogen decomposition in insects, and have a significant and lasting inhibitory effect on the anaerobic and aerobic metabolism of insect cells. At the same time, it has a significant inhibitory effect on the production of succinic acid, one of the metabolites of insects. Therefore, it can be argued that the principle of crane phenol killing tapeworm may be achieved by significantly and lastingly inhibiting the metabolism of insect body cells and cutting off the energy supply for life.
The roundworms of newly slaughtered pigs were put into the nutrient solution and 10-5-10-3 crane herb phenol solution, and the roundworms immersed in the medicinal solution produced excitatory effect within 5 minutes, and the effect was the strongest within 10 to 30 minutes, the elastic curl of the insect body was extremely intense, the insect body had a certain degree of spasm, the activity was weakened after 40 minutes, and after 60 minutes, it was still more active than that of the control group (in the nutrient solution). It has been shown that Tsurus Phenol has a long-lasting excitatory effect on roundworms.
Animal tests have shown that the phenol A, B, C, D and E of Cyrus phenol have certain antimalarial activity, and the dose of 40mg per kilogram of body weight for murine malaria can make the protozoa turn negative.
Crane hydroxol has the effect of promoting the migration of schistosomiasis into the liver and killing adult schistosomiasis in animals, but the efficacy is not high when used alone, and when used in small doses of the synthetic drug nizolium, it can significantly improve the effect of treating schistosomiasis in animals. Crane grass young stem and leaf decoction also has good effect on vaginal trichomoniasis.
4. Effect on the cardiovascular system The product infusion and crane herb have a cardiotonic effect on the heart of the frog in vitro; It can increase the heart rate and contraction intensity of frogs and toads. The water-extracted partially alcohol extract has an inhibitory effect on the in vitro frog heart. Crane grass ethanol extract is given intravenously to anesthetized rabbits and dogs, which can increase blood pressure. And the alcohol extract of its water-extracted part of it makes the blood pressure of the rabbit drop; To rabbits and frogs hind limb vascular perfusion, low concentrations make blood vessels constrict, high concentrations cause blood vessels to dilate. The infusion of crane grass and aqueous extract to the rabbit ear vascular perfusion has no effect at low concentrations and dilated reactions at high concentrations, and can counteract the vasoconstricting effect of epinephrine.
5. Effect on smooth muscle The water extracted partial ethanol extract excitates the excitation of the ex vivo intestinal tract of rabbits and guinea pigs at low concentrations, and inhibits at high concentrations. Crane lactone can reduce the contraction amplitude and tension of the intestines in vitro rabbits, and then stop the intestinal movement in a relaxed state; It also had an inhibitory effect on the peristalsis of the small intestine in place in rats. The impregnation has an adrenaline-like effect on the uterus of ex vivo rabbits and guinea pigs.
6. Other effects Of thistle water extract has a strong inhibitory effect on human cancer cells JTC-26 in vitro, but has no inhibitory effect on normal fibroblasts in humans. Mice were given Agrimoniin 10 mg/kg peritoneal injection before or after inoculation with MM2 breast cancer cells, and the result was that the tumors were almost completely rejected, whether taken orally or intravenously, which prolonged the survival of tumor-bearing animals. The results show that Agrimoniin is a strong anti-tumor tannic acid, and its anti-tumor effect may be due to the drug's enhancement of the host's immune response through the action of tumor cells and certain immune cells. It has been reported that the herb has stable and significant anti-tumor effects, and the components are present in the roots (including root buds) and are alcohol-based substances. Crane grass has a good inhibitory effect on various transplant tumors (S180, U14, B22, W256, EAC-ESC, B16) in animals, and its inhibition rates are 36.2%-65.9%, respectively.
Aqueous extracts and acid aqueous extracts have inhibitory effects on the electrical stimulation of rabbit pain sensation in the pulp. Crane herb can reduce the fragility of mouse and rabbit red blood cells, slightly reducing the effect of basal metabolism in rats. Its alcohol-soluble leachables can excite the respiratory center and also excitate skeletal muscle, which can restore excitement to tired skeletal muscles. In addition, there is also a hypoglycemic effect. (Image source: CFP)