Hepatic granulomas, which may be unfamiliar to some people with the disease, may not even have any concept of the disease. However, if the patient is diagnosed with the disease but does not know the disease, it will have a huge impact on the treatment effect of the disease, such as affecting the communication between doctors and patients. Well, it is important to understand what hepatic granulomas are.
1. Hepatic granulomas
Hepatic granulomas, also known as hepatic granulomas or granulomatous hepatitis, are a group of focal liver diseases. The disease is not a separate disease, it is caused by multiple factors or histological changes associated with certain diseases, and is a non-specific response of the liver to different stimuli. Viruses, bacteria, fungi, parasites, spirochetes, rickettsia infections, tumors, drugs, chemicals, hepatobiliary diseases and other factors can cause hepatic granuloma formation, of which tuberculosis and sarcoidosis occur most commonly. Hepatic granulomas are also seen in brucellosis, syphilis, radiation bacteriosis, and tularemia.
2. The cause of hepatic granulomatosis
There are many causes of granulomatous liver disease, the most important of which are infectious diseases, such as bacterial infections (such as tuberculosis and other mycobacterial infections, Tularellosis, brucellosis, leprosy, etc.), fungal infections (such as coccidioidomycosis, histoplasmosis, etc.), parasitic infections (such as amoeba disease, giardiasis, Trebutychicosis, etc.), viral infections (such as infectious mononucleosis, cytomegalovirus infection, chickenpox, influenza b, VE lymphangigramatoma), and other infections such as rickettsial disease (Q disease), syphilis. Sarcoidosis is the most important noninfectious cause. About two-thirds of patients with sarcoidosis are liver-affected and sometimes the predominant clinical manifestation. Many drugs (eg, phenylbutazone, furuntoin, quinidine, sulfonamides, allopurinol, oral contraceptives, penicillin, etc.) can cause sarcoidosis.
In addition, hepatic granulomatous disease may also be seen in patients with rheumatic polymyalgia, collagen disease, Hodgkin's disease without changes in the morphology of lymphoma, and other systemic diseases. In patients with primary liver disease, cases of hepatic granulomatous disease are relatively rare, of which only primary biliary cirrhosis is the most important cause. In such cases, particularly early in the course of the disease, granulomas around the portal are typical and usually accompanied by other histological changes. Occasionally, a small amount of granulomas can also be found in patients with various other liver diseases, and they are often caused by small droplets of fat, so they are called fatty granulomas, which have no clinical significance.
After understanding the basic description of hepatic granulomas and the description of the cause, it is possible to leave a certain concept of the disease. In this way, when patients receive treatment, because they already have some understanding of the disease, it is easier for patients to accept the advice and prescriptions given by the doctor, thereby improving the effectiveness of treatment.
Find this article useful, welcome to like or recommend to friends, and pay attention to [Medical Association Media].