During the Southern and Northern Dynasties, the Medicine Master Sutra was translated in China and began to circulate, and the belief in Medicine Buddha was gradually formed, and it became popular in the Tang Dynasty. After the Tang and Song dynasties, the practice of medicine Buddha belief was still quite prevalent, affecting regions and countries such as the Western Regions and Japan. There are five kinds of Chinese translations of the Pharmacist Classics, four of which exist in the same content, which are the same, of which the "Medicine Master Sutra" translated by Master Xuanzang is the most popular, and the Translation of the Medicine Master by Master Yijing is the most complete.

Yijing's translation of the "Medicine Master Liuliguang Seven Buddhas Ben Wish Merit Sutra", also known as the "Seven Buddhas Medicine Master Sutra", adds a lot of esoteric aspects, such as changing the medicine man from one Buddha to seven Buddhas. Additions include: Fahai Hui Game Divine Power Rulai, Medicine Master LiuliGuang Rulai, Good Name Auspicious Wang Rulai, Baoyue Zhi Yan Guangyin Zi Wang Rulai, Worry-free Most Victorious Auspicious Rulai, Fahai Lei Yin Rulai, Golden Treasure Light Magic Achievement Rulai. It is expressed that these people who live in the four Ganges sands in the East, and even the ten ganga sand worlds, make a great wish to bring out the sufferings of all sentient beings. Yuanrong, the King of Dongyang during the Northern Wei Dynasty, who served as the assassin of Guazhou, twice copied the Medicine Master Sutra on May 7 and July 15 of the second year of Yongxi (533 AD).
Before the Tang Dynasty, the Medicine Master Sutra was one of the classics that were often written by meritorious deeds at that time, and the Medicine Buddha was already one of the important objects of people's belief and worship. It reflects the gradual prevalence of the pharmacist faith during this period. Enshrinement of the Medicine Buddha statue is one of the most important manifestations of the medicine man's faith, which is prominently expressed in Dunhuang. In the Dunhuang statue paintings, in addition to the Thousand Buddhas, the largest number of single statues is the medicine man Rulai, and there are more than 550 medicine man statues in the Murals of the Mogao Caves alone, a huge number, showing the people's fiery faith in medicine masters.
Dunhuang's Medicine Buddha statue first appeared on the east side of the south wall of Cave 302 of the Sui Dynasty, and in the map of the Medicine Buddha on the north side of the west wall of Cave 305 of the Sui Dynasty, the Medicine Buddha knot sat on a lotus seat, dressed in a large red robe, with a bowl in his left hand, and his right index finger and thumb twisted together as a Dharma seal, and a long banner was hung on the canopy, and four bodhisattvas were standing on both sides. In the Tang Dynasty, the people of Dunhuang made statues to provide for the Medicine Buddha, reaching the peak of perfection, often drawing endlessly in a cave, reflecting the fiery heat of people's belief in worshiping the Medicine Buddha as the scriptures. Seeking peace and longevity is the main wish of people, the Medicine Buddha with the needs of people to eliminate fear, cure diseases, solve difficulties, fulfill wishes and other people's personal needs to attract believers, as long as the name of the Medicine Buddha, you can be liberated from birth, old age, illness, death and other sufferings, can be exempted from the nine kinds of horizontal death.
The Medicine Buddha was able to prolong life, eliminate disasters and diseases, and meet the instinctive needs of many people, so the medicine man belief was very popular at that time.