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Friends who own dogs often ask:
My dog's nose is not black before, it looks not as handsome as before, what is the reason, can it become black again?
This phenomenon is nasal hypopigmentation, common causes are:
1. Genetic factors
Hypopigmentation of the nasal end occurs mainly in pale breeds of dogs, such as: Labrador, Golden Retriever, Husky, Samoyed and so on. With age, the color of the nose fades to brown or white, which is not life-threatening except for the impact on aesthetics.
2. Nutritional factors
The nutrients associated with melanin formation are:
Amino acids: tyrosine, tryptophan, lysine, pantothenic acid, folic acid, biotin, p-aminobenzoic acid;
Vitamins: Vitamins B, C, E;
Trace elements: copper, zinc.
The above nutrients can be supplemented with seaweed powder, soybeans, lentils, green beans, red beans, peanuts, walnuts, black sesame seeds, etc. in the diet.
3. Endocrine factors
Estrogen: Stimulates melanocytes to secrete melanin bodies.
Melanin-stimulating hormone MSH: Increases the activity of tyrosinase by increasing the level of copper ions in the blood, and if there is insufficient secretion, it will affect the formation of pigments.
Adrenocortical hormone: reduces the formation of melanin by inhibiting the secretion of MSH by the pituitary gland.
Melatonin: hypopigmentation .
For such diseases to find the cause, endocrine conditioning is the key.
4. Autoimmune diseases
There are deciduous pemphigus, pemphigus vulgaris, lupus erythematosus, etc., foreign studies have found that canine uveal dermatosis syndrome (VKH) can also cause canine hypopigmentation.
5. Other factors
(1) Ultraviolet rays
Pets live indoors for a long time, and reduced UV exposure is one of the reasons. This can be corrected by extending the daylight exposure time.
(2) Ryukian factor
Long-term application of diluclopropanol, cuscarine, hexanine and other drugs containing lucidyl, can reduce melanin production. Attention should be paid to the choice of topical use of the skin .
(3) Neurological factors
Nerve impulses also have an impact on the formation of melanin. Rapid changes in skin color in some animals (e.g., certain fish, frogs, lizards, etc.) have been shown to be associated with neural control.
Such phenomena are rare in dogs, and for abrupt hypopigmentation, they may be caused by neurological factors and need to be further investigated.
(4) Ectoparasites, skin allergies, deep skin fungal infections, trauma, etc., if they cause damage to the basal layer of the skin, can affect the normal metabolism of melanin, and the prognosis of early removal of the cause is good.
Treatment
Generally by increasing outdoor daylight hours and improving the diet, the color of the dog's nose can be darkened. If nothing changes, consult your veterinarian.
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