What is a recombinant subunit COVID-19 vaccine?
The recombinant subunit vaccine approved for emergency use is the recombinant new coronavirus vaccine (CHO cells) produced by Anhui Zhifeilong Kema Biopharmaceutical Co., Ltd. (Zhifeilong Kema). The principle is to recombine the new coronavirus S protein receptor binding region (RBD) gene into the Chinese hamster ovary (CHO) cell gene, express it in vitro to form an RBD dimer, and add aluminum hydroxide adjuvant to improve immunogenicity.
Is the technology mature for recombinant subunit vaccines?
The technical principle of the recombinant subunit vaccine and the well-established hepatitis B CHO cell vaccine are similar, which is made of vaccines that directly produce antigens in vitro, because only a very small, very short active ingredient is used, the composition is very simple, there are several main surface proteins, so it avoids some of the side effects that other components may produce and vaccine-related diseases.
Are there any major side effects after recombinant subunit vaccination?
According to the results of the previous clinical trial, after the vaccine was fully vaccinated, no serious adverse reactions occurred, which was in line with the characteristics of small adverse reactions of the subunit vaccine. In terms of safety, most recipients did not observe adverse reactions or were mild or moderate adverse reactions, such as redness and swelling, pain at the injection site, itching, etc., which were common reactions after recombinant subunit vaccination.
How long are the doses and intervals?
The recombinant subunit vaccine requires 3 doses, which are given according to the procedure of 0-1-2 months, and can be appropriately postponed in special cases.
Why 3 injections?
Although 2 injections can already produce only slightly lower than the serum neutralizing antibody level of the recovered patient, after 3 injections, not only the neutralizing antibody level is doubled, it can reach twice that of the recovered COVID-19 patient, and the immune effect is more durable. Preliminary clinical data show that the positive transverse rate of neutralizing antibodies after 2 doses of vaccination can reach 83%, and the positive transversion rate of neutralizing antibodies after 3 injections is 97%!
Can it be replaced with an inactivated vaccine product?
According to the Technical Guidelines for COVID-19 Vaccination (First Edition), the recombinant COVID-19 vaccine (CHO cells) and the COVID-19 inactivated vaccine (Vero cell) cannot be replaced during use because they belong to different vaccine types.
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Look at the first end of Zigong 丨 Zigong news
Source 丨Zigong Municipal Health Commission
Edited by 丨 Wang Han
Editor 丨 Chen Qi
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