Uncle Li is 78 years old this year, hypertension for 30 years, blood pressure control is very good, currently taking valsartan amlodipine, plus lifestyle conditioning, blood pressure has been controlled at 120/80mmHg, physical health, mental sorghum.
Half a year ago, Uncle Li took antihypertensive drugs according to his habits, which was different from the previous happy and hehehe, and looked very worried. Asked the reason, only to understand: when he chatted with others, some people said that antihypertensive drugs can not always use one, will produce drug resistance, can not use good antihypertensive drugs, otherwise there will be no drugs available after drug resistance.
It turned out that he was worried about this matter, Uncle Li's blood pressure control was very good, the first few years have been eating valsartan, 5 years ago, when the doctor measured blood pressure, found that the blood pressure is high, has been close to 140/90mmHg. In order to better control his blood pressure, the doctor switched him to valsartan amlodipine. Uncle Li believes that valsartan amlodipine is a good antihypertensive drug, if with the increase of age, blood pressure is getting higher and higher, will valsartan amlodipine also do not work, then is it really no medicine can be used.
Are antihypertensive drugs really resistant? The answer is no.
Let's first understand what is drug resistance, drug resistance refers to the tolerance of microorganisms, parasites or tumor cells to drugs, once the tolerance appears, the effect of drugs will be significantly reduced. But blood pressure is not a microorganism, a parasite, or a tumor cell, so there is no resistance!
Cardiovascular drugs that can be resistant to drugs are only about nitrates, if they have been taken uninterruptedly, may soon develop drug resistance, so it is generally recommended that the process of medication is best set aside 8-12 hours a day without drugs or low drug concentration period.
However, some people question why sometimes one antihypertensive drug cannot be a good antihypertensive drug, and it is necessary to switch or add another antihypertensive drug?
1. Blood pressure is constantly changing with the season
In general, blood pressure decreases in summer and increases in winter, and clinical trials have shown that with the change of month, blood pressure fluctuates seasonally, and summer blood pressure is reduced by an average of 10 mmHg compared to winter blood pressure systolic blood pressure.
Therefore, many people react that the same antihypertensive drugs, the effect in winter is not as good as in summer, which is also the reason. Temperature is a major factor in seasonal changes in blood pressure, and cold environments activate the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS), impair endothelial function, and mediate vasodilation, which in turn causes resistance to small vascular contraction, increased cardiac output, and increased blood pressure. Summer high temperature, the human body sweats a lot, excretes part of the water and electrolytes, blood volume is relatively reduced, is also one of the reasons for the decline in blood pressure, this effect is similar to diuretics.
In addition, because of the cold weather in winter, many people reduce their exercise is also a factor that leads to the rise in blood pressure. Therefore, the poor effect of winter antihypertensive drugs is not because of antihypertensive drug resistance, but because of the increase in human blood pressure. For patients with hypertension, the amount of antihypertensive drugs can be appropriately adjusted according to the doctor's advice and blood pressure measurements, according to the change of season!
2. Blood pressure continues to increase with age
Some people say that since antihypertensive drugs are not resistant, why use the same antihypertensive drugs, blood pressure can be controlled very well, but with the prolongation of time, the final slow effect is not good.
In fact, this and antihypertensive drugs do not have much effect, for hypertensive patients, there is generally a normal blood pressure when young, with the increase of age, hypertension, slowly blood pressure is getting higher and higher. The same drug, when the blood pressure is not very high at the beginning, can control blood pressure very well, for example, when the blood pressure is 150/100mmHg, the blood pressure is controlled in the normal range, but when the blood pressure rises to 180/110mmHg, the blood pressure cannot be controlled within the normal level, but controlled at 160/90mmHg.
It is not the antihypertensive drug that produces resistance, but the cause of the human body itself!
3. Reasons for lifestyle
The same drug, different people apply, the effect is not the same. Uncle Li in the text, lifestyle management is very strict, so blood pressure has been managed very well, but other people, if they often smoke, drink alcohol or like high-fat foods, may not be able to take the same antihypertensive drugs to achieve a good antihypertensive effect.
At present, there are many rumors about antihypertensive drugs, and even lead some people to choose not to take antihypertensive drugs because they are worried about the adverse reactions of antihypertensive drugs or worry that they can't stop eating antihypertensive drugs, which is very dangerous. For patients with hypertension, if you want to prevent complications, you must do the following three things:
<h1 class = "pgc-h-arrow-right" >1. Take antihypertensive drugs on time</h1>
After being diagnosed with hypertension, it is necessary to take antihypertensive drugs on time according to the doctor's requirements, and the adverse reactions of antihypertensive drugs are far lower than the harm caused by hypertension.
<h1 class = "pgc-h-arrow-right" >2</h1>
For people with high blood pressure, it is not enough to take antihypertensive drugs, but it is necessary to monitor blood pressure frequently and adjust the dosage of drugs according to the level of blood pressure. Blood pressure constantly changes with the season, temperature, age, etc., so monitoring blood pressure is crucial!
< h1 class= "pgc-h-arrow-right" >3. Maintain a good lifestyle</h1>
Maintaining a good lifestyle, quitting smoking and alcohol, eating a balanced diet, controlling weight within the normal range, and moderate exercise can make blood pressure more stable and reduce the risk of cardiovascular disease.
Antihypertensive drugs can be taken for a long time, and will not produce drug resistance, but in the process of taking antihypertensive drugs, we must often measure blood pressure, if the antihypertensive drugs that are being taken can not control blood pressure well, you need to switch to other types of antihypertensive drugs!