In recent years, the emergence of the African swine fever epidemic has put forward new requirements for the prevention and control of diseases in China's pig industry. The establishment and continuous improvement of the biosecurity system of pig farms has provided a strong guarantee for the prevention and control of major epidemics. At present, under the stimulation of high market and high profits, the domestic pig industry has resumed production and accelerated the expansion speed, and the pig industry is in full swing to ensure stable production and revitalize the pig industry. In this context, pre-Keqian Biology combined with the current epidemic situation of major swine diseases in China, bringing together many years of practical experience condensed prevention and control programs, launched a prevention and control and purification action for PCP series diseases, and today we will take you to take a deeper understanding.
Q: What is the meaning of "PCP" in the PCP China Swine Disease Purification Campaign proposed by Pre-Science Biology?
Tang Xibiao answered: In recent years, the monitoring results of the main disease epidemics of national group farms, large-scale pig farms and small and medium-sized retail pig farms found that in addition to African swine fever, the epidemic diseases affecting the revitalization of the pig industry mainly include three epidemics of swine pseudorabies, swine fever and swine epidemic diarrhea, therefore, the pre-science biotechnology service system took the lead in proposing prevention and control and purification actions for the three epidemics of swine pseudorabies, swine fever and swine epidemic diarrhea, and the meaning of PCP is the first letter of the English name of these three diseases (swine pseudo rabies, Pseudorabies; swine fever, Classical swine fever; porcine epidemic diarrhea) (Figure 1). We believe that under the non-plague situation, the effective prevention and control and purification of these three major clinical diseases will bring important production significance to the development of China's pig industry, and will comprehensively promote the improvement of China's pig disease prevention and control level.
Figure 1 The meaning of the PCP China Swine Disease Purification Campaign
Q: On what grounds did Pre-Keqian Bio propose the PCP China Swine Disease Purification Campaign, and what was the purpose of the action?
Tang Xibiao answered: We have comprehensively studied the complex situation facing the current pig industry, and the current era background of China's pig industry has the following characteristics: (1) the need for a mature biosecurity system and scientific prevention and control means; (2) the release of production capacity of different scales and the steady recovery of the development of the pig industry; (3) the improvement of breeding level and the transformation and upgrading of the model; (4) the industrial requirements, the market situation to promote the revitalization of the pig industry and the risk can not be underestimated; (5) the emergence of new diseases, the repeated outbreak of old diseases ;(6) Large-scale pig farms are further focused, and pig talents, pig awareness, and concept levels are comprehensively improved. It is based on such an industry situation that Pre-Keqian Bio proposed the PCP China Swine Disease Purification Action.
Under the background of the continuous recovery of the breeding industry, the continuous upgrading of the breeding model, and the aggravation of the complexity of the pig farm disease, Keqian Bio, in line with the occupational requirements of providing help for the sustainable development of China's pig industry, launched the PCP China Pig Disease Purification Action in the core breeding areas, head enterprises and key customers in the country, aiming to reduce the burden on the pig industry and provide technical support for the development of the industry!
Q: What are the difficulties in the implementation of the PCP China Swine Disease Purification Campaign?
Tang Xibiao answered: The difficulty of PCP series disease prevention and control and purification is that it is not easy to grasp the pathogenic characteristics of the disease itself, can not effectively use prevention and control means, and cannot carry out long-term scientific monitoring, which has led to the upgrading of the purification difficulty of these epidemics, especially the wide distribution of China's pig industry, many models, inconsistent pig basic level, and there are differences in epidemic prevention technology and implementation monitoring power.
The purification difficulty of swine pseudorabies is closely related to the virus virulence, the protective efficiency of the classical strain vaccine, the rationality of immunization procedures, scientific monitoring, and comprehensive and accurate implementation; the purification difficulty of swine fever lies in the serious chronic, mild infection and persistent infection of swine fever virus, the mixed infection of swine disease is everywhere, the difficulty of purification is upgraded, the lack of mature identification technology, wild poison and vaccine poison are difficult to distinguish; the reason why it is difficult to prevent and control and purify epidemic diarrhea in pigs is the mutation of the epidemic strain, and the protection of the classic strain vaccine is insufficient. Reserve breeding pigs lack basic immune domestication work, immunization procedures do not have scientific rationality, one-sided thinking in autumn and winter immune prevention and control and ignore the importance of biosecurity.
Q: What are the advantages of Keqian Bio in carrying out this big operation?
Tang Xibiao answered: Keqian Biology took the lead in proposing the PCP China Swine Disease Purification Action mainly from the integration, demonstration and accumulation and support of cutting-edge technology systems.
First of all, since its establishment in 2001, Pre-Kebi Biology has been focusing on the epidemiology and pathogen dynamics of new clinical and sudden swine diseases, in the field of porcine pseudorabies prevention and control, since 2005, it has taken the lead in successfully developing the Chinese epidemic strain pig pseudo rabies genetic engineering vaccine HB-98 strain, in 2012 the Chinese epidemic strain was developed into a genetically engineered live vaccine HB2000 strain, and combined with the immunological characteristics of the swine pseudo rabies virus since 2010, the "live plus kill" immunization program of swine pseudo rabies has been proposed. This technology fully stimulates the body's cellular immunity, humoral immunity and mucosal immunity, and supports gB-ELISA and gE-ELISA differential diagnostic technology, helping many large-scale pig farms in China to achieve the prevention and control, yin and purification of swine pseudorabies. In 2010, the gene type II variant strain diarrhea virus was widely circulated in China, which seriously threatened the development of China's pig industry, and the pre-science biological integration industry technology advantages took the lead in identifying and determining the mutation of the diarrhea virus in China, and determined that the newborn piglet diarrhea was a type II porcine epidemic diarrhea virus, and in 2017 and 2018, the industry took the lead in developing the inactivated vaccine AJ1102 strain and the live vaccine AJ1102R strain for the mutant strain of diarrhea virus in China. In the world, it has taken the lead in realizing the large-scale suspension culture of the flaky carrier of the PEDV vaccine strain, no serum culture, overcome the key bottleneck technology of large-scale production of diarrhea vaccine, and the clinical experience of the "live plus extinguishing" technology program for diarrhea prevention and control is mature, and it has been trusted and recognized by farmers across the country for 4 years, and many head enterprises have chosen this set of technologies for the prevention and control of diarrhea virus, ensuring the stable and healthy development of China's pig industry. In 2020, Keqian Bio further increased investment in scientific research technology, developed into a swine fever E2 subunit vaccine, and combined with E0-ELISA technology, to achieve large-scale pig farm swine fever purification, the vaccine is produced in the intelligent factory platform system, manufacturing costs are 117% lower than the original technology, completely solve the technical bottleneck and cost bottleneck problem of swine fever purification difficult to implement, so that swine fever purification is fully executable and operable.
Second, since the Eleventh Five-Year Plan, Pre-Ke bio has been participating in and undertaking national support plan projects, carrying out the integration and demonstration of purification technology for swine fever and swine pseudorabies, and has accumulated rich clinical experience and technical accumulation, which has laid a good foundation for the national promotion and implementation of PCP projects.
Third, in the first year of the 14th Five-Year Plan, pre-science biology combined the new situation of non-plague, the new dynamics of the industry, the new requirements of the pig industry, and the new technical needs of farmers, and integrated the iron barrel anti-non-technology, precision platform, accurate early warning, and precision prevention and control technology support platform to ensure the implementation of PCP technology (Figure 2).
Figure 2 Technical support of the "Three Fines Project" implemented by PCP China Swine Disease Purification Campaign
Fourth, whether the PCP China Swine Disease Purification Campaign can be landed, the key support point is the customer terminal service, and pre-science biology fully provides preventive veterinarians, clinical service providers and technical lecturers for demonstration customers to share and copy clinical practical technology to ensure the enforceability of technology.
Fifth, practical experience, mainly for the implementation of effective prevention and control and purification strategies to escort. According to these supports, Keqian Bio has further extended and condensed the "three precision projects", "three quasi-projects" and "three sets of equipment" to ensure that this action is carried out effectively and effectively (Figure 3).
Figure 3 PCP China Swine Disease Purification Campaign implementation of the "three sets" of precision equipment support
Q: What progress has been made in the PCP China Swine Disease Purification Campaign carried out by Pre-Ke biotech?
Tang Xibiao answered: 1. The whole set of pig pseudorabies prevention and control and purification technology is integrated, and the purification level (gE>30%, 30% >gE>10%, gE <10%) is divided according to the detection results of pig pseudo rabies gE wild poison antibodies in different pig farms, and then the purification strategy is formulated, the main measures are: (1) the pre-branch biocommune immunization program for enhanced immunization (breeding pig "4+2", piglet "2+1+1" immunization program) ;(2) off-site breeding of negative reserve pigs; (3) phasing out breeding pigs with high fetal frequency and abnormal production ;(4) Use wild poison-negative boar semen; (5) regular gE antibody testing to eliminate positive breeding pigs; (6) standardize production management and avoid crossover; (7) implement strict biosecurity measures, through the implementation of the above program, 124 sub-farms of more than 60 group customers and 750 small and medium-sized benchmark customer pig farms cooperating with Keqian Bio have realized the purification of swine pseudorabies.
2. Formulated the technical route of swine fever prevention and control and purification implementation, according to the characteristics of the current pig farm scale, Keqian Bio and a number of group company scale pig farms, large-scale pig farms in different provinces, small and medium-sized retail households in various regions to carry out a large survey of swine fever epidemic, relying on the platform of pre-keqian biological testing center, using the swine fever E2 subunit vaccine and swine fever E0 antibody detection kit produced by pre-keqian biology to carry out scientific prevention and control and purification actions.
3. Through the on-site service of the company's technical personnel, Keqian Bio summarized and analyzed the main reasons for the occurrence of the epidemic of porcine epidemic diarrhea, that is, immunization was not acted upon, classical immunity was passive, the implementation of the program was discounted, and biosecurity loopholes were stored, and according to the above main reasons, a set of practical plans in line with the current pig farm prevention and control and purification of pig epidemic diarrhea were formulated. In 2020, Keqian Bio dispatched preventive veterinarians to 19 groups, using the immunization program and biosecurity measures of "live + extinguish + extinguish" of pre-keqian diarrhea vaccine and fetus, to effectively prevent and control the epidemic of swine diarrhea in these pig farms.
These are the technical accumulation and experience data support of pre-science biology for many years to actively implement clinical service strategies.
Q: How can pig farms contact pre-science biology when they launch the PCP China Swine Disease Purification Campaign Project? What technical support does Keqian Bioengeric provide?
Tang Xibiao answered: Disease purification provides an important safety guarantee for pig farm production, at present, Keqian Biology has joined hands with pig farms of different sizes across the country to carry out PCP China Pig Disease Purification Action, and has achieved rich clinical experience and achievements. Therefore, the breeding friends who are interested in the purification project in the industry need the technical support of Pre-Science Bio, and can get in touch with the relevant personnel of the Pre-Science Biotechnology Service System through the following channels.
1. The group breeding company can get in touch with the business manager who serves the group, and we have preventive veterinarians, clinical service providers and technical lecturers who specialize in serving the group's customers, and conduct all-round communication with the relevant person in charge of the pig farm;
2. The large-scale breeding company can get in touch with the key account manager who serves the pig farm, and we have clinical service providers and technical lecturers who specialize in serving the big customers, and conduct all-round communication with the relevant person in charge of the pig farm;
3. Contact the relevant personnel of the diagnostic center through the pre-clinical testing platform, and then obtain the contact information of the marketing and technical service personnel;
4. You can get in touch with the training instructors through online (e.g. Keqian cloud forum) technical lectures or offline on-site exchange meetings, so as to conduct all-round discussion and service exchanges;
5. You can log on to the official website of Keqian Bio to get the contact information of the relevant personnel of the marketing center or technical service system, get in touch with us, and then we will send someone to track the service.
Keqian Bio launched the PCP China Swine Disease Purification Campaign in pig farms nationwide, and the technical support it can provide mainly in the following aspects:
1. Invite practical experts to communicate with the management level and provide technical assistance for the breeding company from a professional point of view;
2. Dispatch relevant personnel of the technical service system to connect with the front-line person in charge of the breeding company layer by layer, and plan and design the purification plan according to the actual situation of the pig farm;
3. Dispatch preventive veterinarians or clinical service technicians to participate in the front-line production work of the breeding company and guide the purification of PCP swine diseases in pig farms;
4. Dispatch technical lecturers to local breeding companies to carry out PCP technical training on chinese swine disease purification work.
The implementation of PCP China's swine disease purification action not only reduces economic losses for pig farms, but also provides a strong guarantee for the safe production and population optimization of pig farms under the current situation, and Keqian Bio is willing to work with you to open the door of pig disease purification.
Attached: Introduction of Tang Xiaobiao
Tang Xiaobiao
Tang Xibiao: Doctor of Preventive Veterinary Medicine, Huazhong Agricultural University, Senior Veterinarian, Director of Animal Disease Detection Center, Senior Management Personnel and Core Technical Personnel of Huazhong Agricultural University.
As the project host and main finisher, Mr. Tang Xibiao has been authorized to have 6 national invention patents, participated in the research and development and clinical trials of 7 new veterinary drugs of the company, and presided over the market application and technology promotion of vaccine products.
He has participated in the National Natural Science Foundation of China project "Functional Identification of Haemophilus parasine cdtABC gene cluster and its role in the continuous infection and pathogenesis of bacteria", the key project of the National Natural Science Foundation of China "Research on the Genomics and Molecular Pathogenesis Mechanism of Parenteral Pathogenic E. Coli", the 13th Five-Year National Key Research and Development Program project "Pig Pseudorabies, Regional Purification and Eradication of Swine Fever and Breeding Farm Highly Pathogenic Blue Ear Disease Purification Technology Integration and Demonstration" and the 2019 Hubei Provincial Technological Innovation Special Project" Research on key technologies for the prevention and control of African swine fever" and other major national or provincial projects.
He has been in the clinical frontline for a long time, collecting, sorting out and compiling clinical cases of swine disease, and participating in the editing of books and technical publications such as Veterinary Manual, Molecular Basis of Streptococcus swine Pathogenesis, and Manual of Swine Disease Prevention and Control. In practice, the prevention and control technology of pig pseudorabies, the immune prevention and comprehensive prevention and control technology of diarrhea-like diseases in pigs are integrated and matured, and they are promoted and applied in demonstration farms.
He has published 31 articles in Chinese academic journals, 13 articles in English SCI, and 7 papers in international conferences. The scientific research project "Promotion and Application of Inactivated Vaccine for Haemophilus Parasine Disease" won the third prize of Hubei Provincial Science and Technology Achievement Promotion, and the scientific research project "Integration and Promotion and Application of Efficient and Safe Prevention and Control Technology for Swine Streptococcal Disease" won the first prize of Hubei Provincial Science and Technology Achievement Promotion Award.
The author of this article | Pre-Ke bio: Tang Xibiao, Shangshu, Zeng Songlin, Tan Li