I believe that many people have heard of the phrase "cephalosporin with wine, say and go", and most of the public is convinced of the authenticity of this sentence. But as this statement circulated, some people questioned it:
Weibo well-known blogger "Huipu" once made a statement on Weibo, saying that "cephalosporin is wine, drinking and leaving, is fake":
Graph source network
The official blog of "Science Park" also published an article "Is it life-threatening to drink alcohol after eating cephalosporin?" , which means that this is almost a folk rumor that lacks evidence at all.
In this regard, many netizens told everyone with their personal experience that this sentence is really not "joking":
@A Zi who wants to be on the list: Hey... I remembered that I had eaten methyl file for three consecutive days before I had my wisdom teeth pulled out, drank a glass of red wine every other day and a half, and sent a critical notice to my parents when I was sent to the hospital that night...
@ is xiao He ya: last year, the wisdom teeth were extracted and ate tinidazole, and then drank two bottles of Japanese sake, and the result was sent to the hospital for rescue, almost did not rescue it, really thrilling!
Have you ever experienced anything like this? Or has something similar happened around you?
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Taking medicine after drinking alcohol should be cautious, especially to avoid adverse reactions, but there are still many people who think that the probability of "cephalosporin with wine, saying and walking away" is small and small, but can it really be taken lightly? The disulfiram reaction caused by cephalosporin wine is not to be underestimated!
After taking cephalosporin after drinking alcohol, it is easy to affect the normal metabolism of alcohol in the body, and even more will cause alcohol metabolite acetaldehyde to accumulate in the body, which will then cause adverse reactions in the body's respiratory, digestive and nervous, circulatory and other systems.
These adverse reactions are mildly manifested as nausea and vomiting, diarrhea, dizziness, palpitations, sweating, etc.; more severe, there is a risk of respiratory depression, blood pressure drop, myocardial infarction, heart failure and even shock, which is the so-called disulfiram reaction.
Some people in life have tried to use cephalosporin with wine, but the body has not produced any adverse reactions, how can this be explained?
In fact, cephalosporin wine will produce disulfiram reactions, mainly because cephalosporins contain a structure of "tetrazole", which can inhibit acetaldehyde dehydrogenase and make acetaldehyde accumulate in the body.
After some people drink alcohol, taking cephalosporin does not produce an uncomfortable reaction, mainly because not all cephalosporins contain the structure of "tetrazole", such as cefpirine, cefotaphene and cefadroxam, etc., and not all cephalosporin drugs have disulfiram-like reactions in clinical trials. Nevertheless, for safety reasons, it is better not to take cephalosporins after drinking alcohol.
<h1 class="pgc-h-arrow-right" data-track="49" > second, not only cephalosporin, these drugs can also be poisoned with alcohol</h1>
It is often possible to hear the famous saying that "do not take medicine after drinking, take medicine and do not drink alcohol", in fact, in addition to cephalosporin can not be mixed with alcohol, there are five major classes of drugs that are also easy to react with alcohol and have fatality.
Sleeping pills + alcohol = one life
Common sleeping pills include diazepam tablets, phenobarbital and chlorodiazepine tablets, which can inhibit the brain, but under the action of alcohol, they will be rapidly absorbed by the body, while the metabolic rate will slow down, resulting in a sharp increase in the concentration of drug components in the blood in the short term.
At this time, the brain center will be excited by alcohol first and then under the dual inhibition of sleeping pills, drowsiness, dizziness, etc. Will appear, and in severe cases, it will be coma, respiratory failure, shock, and even death.
Painkiller + alcohol = gastrointestinal bleeding
Including paracetamol, aspirin and other painkillers, will stimulate and damage the gastrointestinal mucosa, coupled with alcohol will also damage gastrointestinal health, the two together will aggravate the gastrointestinal damage, directly leading to gastritis, gastric ulcer and gastric bleeding.
Antihypertensive drugs + alcohol = hypotensive shock
Antihypertensive drugs are nifedipine, captopril, amlodipine are more common, taking such antihypertensive drugs and then drinking alcohol, is likely to cause vasodilation, followed by hypotension, severe shock symptoms, or life-threatening.
Hypoglycemic drugs + alcohol = hypoglycemic shock
Alcohol is easy to stimulate the secretion of insulin, for sugar friends if you drink alcohol during taking hypoglycemic drugs, then it is easy to cause hypoglycemia problems due to increased insulin secretion. And the performance of sugar friends such as panic and sweating after drunkenness is easy to be confused with the symptoms of hypoglycemia, and if it is not dealt with in time, it will cause hypoglycemic shock problems.
In addition, it is particularly important to pay attention to the mixing of hypoglycemic drugs such as metformin with alcohol, which can easily cause rare but serious side effects and easily increase the risk of lactic acidosis in the patient's body.
Cold medicine + alcohol = liver failure
At present, most of the cold medicines contain acetaminophen, which can alleviate headaches and treat cold symptoms, but when acetaminophen is converted in the body, it will produce a toxic metabolite, which usually requires the combination of protective factors such as reducing glutathione in the body to weaken its toxicity.
However, if you drink alcohol after taking cold medicines, you will consume glutathione in the body, and the toxicity of acetaminophen metabolites will not only not decrease, but will increase the risk of liver failure.
<h1 class="pgc-h-arrow-right" data-track="50" >3. Is there any way to avoid disulfiram reactions? </h1>
Every time there is a dinner, party and other occasions is always indispensable to "drink a cup", if you are taking medicine at this time, is there any way to avoid the disulfiram reaction?
In fact, the most effective and direct way is to do not stick to the drops of alcohol during the medication, especially when the instructions for the drugs taken have clearly stated that "it is not advisable to drink alcohol during taking the drug", then do not drink again.
If the drug instructions do not state whether alcohol can be consumed during the medication, then if the contents of the drug instructions are inaccurate, you can consult the opinions of professionals such as doctors or pharmacists, which will be safer.
However, it is inevitable that you need to touch glasses with people when you have a party for dinner, so what should you do?
It should be noted here that the drug metabolism in the body takes time, if you eat the cephalosporin drug first, then it is recommended to drink alcohol after six to seven days of medication, which can ensure that the drug in the body has been fully metabolized;
If you drink alcohol first, you must also take cephalosporin drugs after three days, which can ensure that the alcohol in the body has been metabolized.
Chinese table is always inseparable from wine, drinking can enliven the atmosphere can close interpersonal relationships, but we must keep in mind the cross motto of "drinking without taking medicine, taking medicine without drinking", every year because of drinking and dispensing medicine, and cases of entering the hospital are not uncommon, for health or do not do this!
#谣零零计划 #
Resources:
[1] "Cephalosporin with wine, just go"? note! Drugs that require abstinence are also these...". Popular Science China.2020-05-07
[2] "Cephalosporin with wine, just go"! Spring Festival dinner, you must know the "disulfiram-like reaction" →". Pudong released.2020-01-17
[3] "Cephalosporin with wine, eat it and leave?" Drugs that need to be avoided, and these" and these. Fruit shell.2019-02-06
[4] "Cephalosporin sends wine, just go!" "Recently, many people have almost lost their lives because of this". Southern Morning Post.2020-01-16
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