Many people around me may have gastroesophageal reflux disease, but they do not know what the reason for frequent acid reflux heartburn is.
In fact, this disease is because most of the stomach is stomach acid, stomach acid is dilute hydrochloric acid, which is very corrosive.
The second is pepsin, as well as bile and pancreatic enzymes that come up from this duodenum, which accounts for a small part of the reason. Then the substance is regurgitated into the esophagus with the reflux, and the esophagus is equivalent to being stimulated by a strong corrosive substance, so it will produce acid reflux, heartburn, chest pain, belching, and if we do gastroscopy, we will also see that some patients will have the phenomenon of rupture of the mucous membrane.
After a long time, there will be ulcers and even some other complications, which is generally called gastroesophageal reflux disease.
This disease was relatively rare in China at the earliest, the main reason is that on the one hand, it is related to this obesity, because the negative pressure is too large, how easy it is to reverse the fat, and the other is to say that it is related to eating more, the load of the stomach is too heavy, it cannot be discharged, then it is reversed. There is also a cardia, which is a gate of the stomach and esophagus, usually closed very tightly, stomach acid is not easy to come up.
But if the innate cardia is relatively deep, the age is loose, and the buckle is loose, so the stomach acid can't be controlled. There are also some special cases, for example, maybe the gastroscopy will see that the esophageal diaphragm muscle is loose, it cannot be in a fixed position, a small part of the stomach will come up, and then the floodgates of the chest cavity will be more loose and so on.
Many people with gastroesophageal reflux disease should take acid suppressive drugs, and there are many side effects of taking acid suppressants for a long time, and I hope more patients understand!
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<h1 class="article-title" what are the adverse reactions and side effects of long-term use of acid suppressants >? </h1>
With the increasing clinical application of acid suppressants such as omeprazole, its adverse reactions have gradually attracted the attention of doctors and patients, common adverse reactions are headache, diarrhea and abdominal pain, pharyngitis, nausea, dizziness, rhinitis, constipation, drug rash and dry mouth, etc., and the incidence of various adverse reactions is between 1% and 5%.
Rare adverse reactions include fever, elevated serum transaminases, hepatitis, liver failure, hepatic encephalopathy, skin necrosis, urticaria, angioedema, taste abnormalities, esophageal candidiasis, hyperhidrosis, depression, anxiety, confusion, hallucinations, leukocytes or thrombocytopenia, interstitial nephritis, male mammary feminization or impotence.
< h1 class="article-title" > how safe is it to apply acid suppressants such as omeprazole for a long time? </h1>
Short-term application of acid suppressants such as omeprazole is reliable and safe for certain acid-related diseases. However, when treating GERD, long-term, or even lifelong maintenance of the drug is required, so the safety of its long-term application has attracted widespread concern.
A large number of clinical safety trial results and their consensus opinions show that there is no obvious clinical correlation between long-term application of acid suppressants such as omeprazole and intestinal pheochromocyte proliferative carcinogenesis, increased formation of carcinogens in the stomach, and cancerous degeneration of atrophic gastritis. However, it should be mainly potential for intragastric bacterial overgrowth and absorption of nutrients such as vitamin B12.
<h1 class= "article-title" >what is gastrointestinal motility drug, and what kinds are commonly used? </h1>
Theoretically, GERD is a motility disease of the upper gastrointestinal tract, and the treatment should correct the dynamic disorder, increase LES tone, enhance the esophageal clearance function, and increase gastric emptying.
Common ones are:
1) Metoclopramide, trade name gastric reassurance, anti-taulin, mainly promotes upper gastrointestinal dynamics, increases LES pressure, strengthens esophageal and gastric peristalsis, thereby promoting gastric emptying and preventing gastroesophageal reflux. In high doses or with long-term application, there may be invertebral in vitro adverse reactions such as akathisia, dyskinesia, increased muscle tone, and convulsions.
2) Domperidone, also known as morpholine, has a mechanism of action similar to metoclopramide, rarely passes through the blood-brain barrier, so extrapyramidal symptoms do not occur, but can promote the secretion of prolactin. It is commonly used clinically.
3) Cisapride, with 5-HT3 and 5-HT4 receptor agonist effect, increases RESTing pressure of LES, strengthens esophageal peristalsis contraction, promotes gastric emptying and improves sinus duodenal coordination. Clinically, it can improve the symptoms of gastroesophageal reflux and promote the healing of esophagitis. When combined with macrolide antibiotics and antifungals, severe arrhythmias and even death can occur, and adverse reactions limit their clinical application.
4) Mosalpride, a new mixture of 5-HT4 receptor agonists and 5HT3 receptor antagonists, can promote upper gastrointestinal motility and effectively reduce gastroesophageal reflux. There were no obvious toxic side effects in clinical application, and the efficacy was exact. Others such as Ula choline, levosulpride and so on.
<h1 class="article-title" > what are the commonly used mucosal protectors in clinical practice? </h1>
When gastroesophageal reflux causes inflammation, damage, erosion or even ulceration of the esophageal mucosa, the application of mucosal protectors can form a protective film on the surface of the mucosal membrane of the lesion, protect it from further damage, reduce symptoms, promote inflammation recovery, and have a certain effect.
1) Aluminum magnesium carbonate, trade name Darcy, is a drug that can both neutralize stomach acid and reversely bind bile acid.
2) Sucralfate, an alkaline aluminum salt of sucrose sulfate, mainly adheres to the damaged mucous membrane in an acidic environment, blocking the digestion of gastric acid and pepsin.
3) Colloidal bismuth agent, trade name is Deno, Lizhu Del, Dile, etc., form a protective film in the damaged mucosa to prevent damage to the mucous membrane by gastric acid and pepsin. Often causes black stools. Long-term use needs to monitor the concentration of bismuth, more than 50 ml / L can cause encephalopathy, so the course of treatment should not exceed 4-6 weeks.
4) Prostaglandin E, which has the effect of inhibiting gastric acid secretion and protecting the mucosa of the stomach and duodenum. Others such as alginates, montoster preparations, mezlin-S and so on.
<h1 class="article-title" > how effective is Chinese medicine in treating gastroesophageal reflux disease? </h1>
GERD is mainly manifested by acid reflux, heartburn, nausea and retrosternal burning pain, and according to its clinical manifestations, the disease belongs to the categories of "spitting acid, noisiness, and stomach pain" in traditional Chinese medicine. The onset is in the esophagus and involves the liver, gallbladder, spleen, stomach and other organs. The main etiology can be summarized as hepatobiliary loss of drainage, spleen and stomach rise and fall disorders, gastric loss and descent. @Destroy virus
Clinically, the basic principle of treating GERD is to relieve liver and qi and reduce gastric reversal, and the dialectical treatment of traditional Chinese medicine can improve chest pain, heartburn and other symptoms, and also has a good effect on oral pain caused by bile reflux. It can be used in combination with Western medicine and can also be used as an adjunct to endoscopic treatment and after surgical treatment. #Headline Health ##Health Care ##Health Science Contest ##Health Science Contest #@Southern Health