Introduction: Peking University Medical Women Doctor Health Says Original American Article No. 383
<h1 class="pgc-h-arrow-right" data-track="2" > how does the fructose in the drink you drink hurt your kidneys? </h1>
After drinking drinks, the fructose in which fructose can increase uric acid and cause gout, in fact, it can also hurt the kidneys, which has the reason for high uric acid, and there are also inflammatory factors promoted by fructose.
Today's science popularization, let's talk about the damage to the kidneys of frequently drinking fructose drinks.
We already know that the ingested fructose in the liver by fructokinase catalytic production of sugar-1-phosphate, the need to consume ATP as a phosphoric acid donor, on the one hand will lead to elevated uric acid, another result is to deplete the liver cells of ATPA, resulting in increased fat mobilization in the liver and kidneys, mitochondrial oxygen production, which in turn leads to cellular oxidative stress, promoting apoptosis, necrosis, endothelial dysfunction and pro-inflammatory factor secretion, thereby promoting the progression of chronic kidney disease.
Although hyperuricemia is a prerequisite for the development of gout, reduced renal uric acid excretion is an important cause of the development of gout.
Clinical studies have confirmed that the blood uric acid level and renal uric acid excretion under short-term acute fructose load are increased, indicating that fructose can significantly increase the blood uric acid level of normal people.
Although the effects of fructose on metabolic syndrome or chronic kidney disease are not well understood, the conclusions of a recent study insist that the potential importance of fructose as a mediator of kidney disease or metabolic syndrome should not be ruled out.
Uric acid-induced endothelial dysfunction can increase insulin antagonism and the risk of cardiovascular disease, affect the dilation of renal blood vessels, and lead to physical work.
<h1 class="pgc-h-arrow-right" data-track="13" > fructose diet, which is a risk factor for the development of chronic kidney disease</h1>
At this point, we should understand that fructose ingested by the fructose diet induces excessive production of uric acid, and works together to damage kidney tissue function through oxidative stress, inflammatory response, and endothelial cell damage.
This proves that the fructose diet is a risk factor for the development of chronic kidney disease.
In studies of models of heat stress and dehydration, fructose supplementation with body fluids can quickly lead to an inflammatory response compared with equal amounts of insufficient fractions, and the prognosis for kidney disease is worse.
In a study that studied the effects of metabolic syndrome on renal function, feeding mice with metabolic syndrome and hyperoxaluria a 60% fructose diet induced oxalic nephropathy and hyperoxaluria.
Moreover, metabolic syndrome can cause significant damage to the renal function of rats with high oxalic acid urine, showing a significant decrease in high creatinine clearance, crystal precipitation leading to tubular damage, and then increased tubular synthesis of osteopontin, but the above changes did not occur in rats without metabolic syndrome.
<h1 class="pgc-h-arrow-right" data-track="18" > high uric acid or a risk factor for inflammation and cardiovascular disease</h1>
Clinical studies have also confirmed that high uric acid is also a risk factor for inflammation and cardiovascular disease. Uric acid plays an important role in the development of pulmonary hypertension and systemic arteriosclerosis, leading to an increased cardiovascular risk.
In this way, re-evaluating fructose intake in the diet and fructose intake in beverages can better control uric acid levels in people with hyperuricemia or gout, thereby reducing associated metabolic complications.
Those who want and are regulating uric acid levels through fresh lemon juice, if you want to avoid the effect of fructose in lemon juice on uric acid, you can consider switching to direct citrate drugs such as potassium citrate sodium, potassium citrate or the new solid drink ZhengxiaoJian effervescent tablets to alkalinize the urine to increase the uric acid content in the urine to promote uric acid excretion in the body To reduce serum uric acid in the body to prevent gout attacks.
In short, our goal is: uric acid may be high, gout will not be committed again.
Reference to this article: Zhang Xiting's article "Research Progress on Fructose Induced Hyperuricemia and Kidney Damage" in the 10th issue of the Journal of Clinical Nephrology in 2019.
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