Curriculum Quality Standards for Northwest A&F University Immunology and Biopharmaceuticals/2160406-2019
Immunology and Biopharmaceuticals
Immunology and Biopharmaceutics
(Course Code: 2160406)
Preface
In order to standardize curriculum teaching, strengthen the goal management of course teaching, reflect the basic requirements of professional training programs for students in terms of knowledge, ability and quality, and combine the actual development of disciplines in schools, the curriculum quality criterion of Northwest A&F University is specially formulated.
Course quality standards are teaching guidance documents that stipulate the nature of a course, course objectives, content framework, and implementation suggestions. It is an intermediate bridge between curriculum planning and classroom teaching, which can ensure that different teachers carry out teaching work effectively, consistently and consistently, which has a direct guiding effect on teachers' teaching and has an important impact on the quality of the curriculum. At the same time, it is also the basis for the preparation of teaching materials, teaching evaluation and examination propositions, and is the basis for school management and evaluation of curriculum. Compared with the syllabus, the curriculum quality standards are elaborated in detail and clear in several parts such as the basic concept of the course, the course objectives, and the proposals for the implementation of the curriculum, especially the basic requirements for learning for all students.
Hours/credits of this course: 20/1
Prerequisite courses for this course: Immunology and Biopharmaceuticals
Course Attributes: Theoretical Lessons
This standard is based on the rules stipulated in GB/T1.1-2009.
This standard is proposed and centralized by the Academic Affairs Office of Northwest A&F University.
The drafting unit of this standard: Microbial Virus Immunology and Bioinformatics Course Group of The College of Veterinary Medicine, Northwest A & F University
The main drafter of this standard: Zhang Deli.
This standard is the first time it has been published.
Quality standards for immunology and biopharmaceuticals courses
1 Range
This standard specifies the introduction, teaching objectives, general requirements, teaching requirements, student learning strategies, curriculum assessment requirements, and teaching quality evaluation and improvement of immunology and biopharmaceuticals.
This standard applies to undergraduate students of any major in the university, including humanities and social sciences and science, engineering, and agriculture.
2 Normative reference files
The following documents are essential for the application of this document. Where a reference file is dated, only the dated version applies to this document. The latest version of any undated reference document (including all amendments) shall apply to this document.
GB/T 7713.1-2006 Dissertation Writing Rules
GB 7714-2005 Rules for bibliographic references after the text
Northwest A & F University 2019 Edition Discipline Training Program (XXX Major)
Measures for the Administration of Undergraduate Status of Northwest A&F University (No. 286 [2017] of the University)
Regulations on the Work of Undergraduate Examinations of Northwest A&F University (No. 364 [2019])
Implementation Rules for the Management of Textbooks of Northwest A&F University (No. 241 [2020].
3 Course Introduction
Opened at Northwest A&F University for 15 years, 2019 headline sharing, global live broadcast since the new crown epidemic in 2020.
Zhang Deli, a doctoral supervisor of high-level talent professors and professors of Northwest A & F University, opened a 30-hour and 1-credit general education course "Immunology & Biopharmaceutics" in the autumn of 2007.
As the original positioning of the "Northwest A&F University Of Science and Technology Public Selection Series of Modern Biomedical Seminars and General Studies Courses", the early English-Chinese bilingual teaching, the professional systematization is also strong, and later more emphasis is placed on general knowledge, the nature of the new student seminar or undergraduate seminar has never changed, focusing on medical and health content, supporting students' survival life, learning and research, work practice and hobbies, to meet the main needs of most students, humanities and social sciences any student can choose to take.
College human health technology series "Immunology & Biopharmaceutics" general education class out of the ivory tower, to the homes of ordinary people in Our country, the autumn of 2019 began to teach videos all on today's headlines, in the spring of 2020 began to broadcast globally, directly to the public!
Immunity means disease resistance, the role is to resist infection, maintain self-stability and surveillance, the original core role is to defend against pathogenic infection. The ever-changing immunology, which is both basic and clinical, is closely related to all aspects of medical life, and with the gradual generalization of narrow immunology, immunology exists almost everywhere there is life, and it has become a compulsory basic course for almost all disciplines of medical life.
The rise of biopharmaceuticals and the development of biotherapeutics were great advances in medicine in the last century and were associated with immunology. Therefore, it is combined with immunology to become a general course "Immunology and Biopharmaceuticals". Biopharmaceuticals has long become a hot new field of pharmacy, since its birth has been the focus of public attention, rapid progress, rapid progress, rapid development and application, research and development applications but difficult, a class of new drug invention is still difficult, first of all, the sky-high investment is daunting. At the turn of the century, the successful development and application of a new drug took 1 billion US dollars for 10 years, and now it is still no less than 1 billion US dollars for 8 years, although it is supported by omics, bioinformatics and systems biology.
In short, "Today's Headlines" certified "Northwest Agriculture and Forestry University Professor Tsinghua University of Technology Peking University Double Postdoctoral Fellow" of "Qingbei Medical Brother Zhang Deli", settled in the "Professor Zhang Deli Qingbei Bohou Bei medical researcher, specializing in medicine and health three agricultural industry science and technology education financial investment live e-commerce, open virus immune tumor information nutrition food and medicine, double creation financial and health science education philosophy general knowledge course", the introduction is opportune! Objective: To meet the needs of social development, to build a similar MOOCs platform for the exchange and interaction of health science and technology general education courses.
Course Description:
Main contents:
Immunology and biopharmaceuticals are difficult to "teach" and difficult to "learn". Immunology is taught in four parts: basic, clinical, applied, genomic and post-genomics. Three lectures are given on introduction, case studies, omics and post-genomic drug development in biopharmaceuticals.
Chapter 1: Introduction to Immunology and Biopharmaceuticals
Article 1 Basic Immunology
Chapter 2 Antigens Chapter 3 Immunoglobulins and Antibodies Chapter 4 Complement System Chapter 5 Cytokines
Chapter 6: Major Histocompatibility Complexes and Their Encoded AntigenIc Systems
Chapter 7: Composition and Main Roles of Immune Organs Chapter 8: Constituent Cells of Adaptive Immunity
Chapter 9: The Constituent Cells of Innate Immunity Chapter 10: Adaptive Immune Responses Chapter 11: Intrinsic Immune Responses
Chapter 12: Immune Tolerance Chapter 13: Regulation of the Immune Response Chapter 14: Immunogenetics
Title II: Clinical Immunology
Chapter 15: Hypersensitivity Chapter 16: Autoimmunity and Autoimmune Diseases Chapter 17: Immunodeficiency Disorders
Chapter 18: Anti-Infective Immunity Chapter 19: Tumor Immunity Chapter 20: Transplant Immunity
Part III: Immunological Applications
Chapter 21: Immunological Testing Techniques and Applications Chapter 22: Immunological Prophylaxis Chapter 23: Immunological Therapy
Title IV: Immunogenomics and Post-Genomics
Chapter 24: Immunomics Chapter 25: Immunobiosinformatics Chapter 26: Immune System Biology
Part V: Introduction to Biopharmaceuticals
A comprehensive review of biopharmaceuticals, focusing on the concept and development of biotechnological drugs; the research and development of biotechnological drugs and the general production process and control of biotechnological drugs; the systematic introduction of the sources, structure, properties, functions, uses and usage of important biotechnological drugs, including interferon drugs, interleukins and tumor necrosis factor drugs, hematopoietic cytokine drugs, growth factor drugs, recombinant polypeptides, protein hormone drugs, drugs acting on the blood and thrombin system, therapeutic enzymes, Antibodies and vaccines, gene therapy and antisense drugs, etc.
Title VI Cases of Biopharmaceuticals
Taking vaccines as an example, the whole process of research, development and industrialization of biological products is elaborated, so that students can have an in-depth understanding of these three processes and their details from the overall situation, and introduce the research and development of biotechnology drugs.
Title VII Biopharmaceutical omics and post-genomic drug development
Chapter 29: Biopharmaceutical omics Chapter 30: Pharmaceutical Bioinformatics Chapter 31: Systems Biology of Drugs
Chapter 32: Genomic and Postgenomic Drug Development
4 Teaching objectives
Teaching through this course should achieve the following objectives:
International exchanges and cooperation, scientific and technological expression practice;
Natural Humanistic Philosophy, Fine Arts and Art Society.
Human nature, financial intelligence, and the logic of making money;
Birth, longevity, death, scientific three views of life.
5 General requirements
Subvert the cognitive hierarchy, enlighten the thinking,
Improve the way of behavior, improve the pattern of the realm.
Supporting survival and promoting learning and work;
Safe, healthy and happy, the great rejuvenation of the nation.
6 Teaching requirements
Course theory content and class time allocation
Table 1 Course content and class time allocation
<col>
Lecture 1
Teaching content
Credit Hour Allocation
theory
experiment
exercitation
problem
discuss
subtotal
Lecture 1
Introduction to Immunology and Biopharmaceuticals, Principles and Methods of Independent Learning achievement in colleges and universities
2
Lecture 2
Immunological Fundamentals and Concepts
Lecture 3
Background requirements for science and vaccine development (mink parvovirus as an example)
Lecture 4
Cell line carcinogenic toxicology and vaccine development process (mink parvovirus as an example)
Lecture 5
Basic and Clinical Immunology
Lecture 6
Food, Pharmaceuticals and Regulatory Sciences
Lecture 7
Methods and art of scientific research
Lecture 8
Systematic biological mechanism of pig model of major respiratory virus disease
Lecture 9
Scientific innovation oral report: capsaicin artificial antigen weight loss and sepsis immune cell model
Lecture 10
oral test
Total
20
7 Student Learning Strategies
In the course of course learning, the teacher's teaching is the key to students learning the course, and taking good class notes is the basis for learning. On the basis of reading the bibliography and other teaching resources provided in this standard, develop a study plan and expand your knowledge horizons. More than three learning methods can be adopted: systematic, problematic, and inductive.
Teaching practice of improving the comprehensive ability of viral immune tumor information and general education
It is believed that innovative talents are particularly important to start from the cultivation of undergraduate students, vigorously reform and even completely subvert the traditional undergraduate teaching, the most obvious performance in the teaching of the publicly elected general education courses in the whole university, the American undergraduate education characteristic courses commonly used in first-class universities at home and abroad ---- the Fresman Seminar (Small Class of 8-30 people) for the first time to introduce 4 undergraduate public elective courses with a limit of 130 and 200 people per course, and it is not easy to be recognized by students. Students of publicly elected general studies at different grades of Northwest A&F University have the opportunity to have an equal discussion with Professor Zhang Deli, who teaches the course, that is, a thematic discussion course. Students conduct research on a topic with the opening professor in small groups, conduct group discussions under the guidance of professors, conduct oral question debates, and summarize the guidance of critical final essay writing. At the beginning of the course, the bibliography and the full text search url of the international free electronic journal are given and a unique method is given, which is convenient for students to learn on their own after class. At the beginning, the requirements for students' course selection standards (http://delizhang.bokee.com/viewdiary.23374069.html) have actually become the goals and directions of future training: in order to ensure interactive teaching of critical and innovative thinking, bilingual teaching in English and Chinese as much as possible, oral report examinations based on scientific research and innovative ideas, supplemented by examinations for writing course review essays, students are required to have a higher Level of English and a certain degree of scientific literacy The following four must have one of the following: English proficiency high level 6 passed; base class students; persistent research and innovative thinking active; able to speak eloquently and comprehensive quality. Students are recommended to divide into primary, intermediate and advanced classes and upgrade the three courses of tumor virus immunization to professional courses, which shows that the teaching has achieved results. After clarifying the quality education requirements for publicly elected general education courses in schools, we will reduce the professional, systematic and bilingual requirements of public elected courses, and continue to adhere to practicality, fun, progress and popularization. After changing the number of elected general studies classes from 30 to 20 hours, Professor Cheung Tak Lee emphasized taking into account the main needs of students of different grades, striving to solve problems well in the classroom, and appropriately retaining the teaching characteristics formed before. Professor Tak Lee has started a teaching blog that has become a platform for students to interact with teachers anonymously. The school-wide elected general studies courses are also distributed to students and posted on blogs (e.g. http://delizhang.bokee.com/viewdiary.18624351.html), The pre-announcement (http://delizhang.bokee.com/viewdiary.21199775.html) of course performance evaluation standards that highlight the learning effect of innovative thinking and the improvement of comprehensive quality has become a weather vane for undergraduate students to choose courses. He always insisted on letting students evaluate and make suggestions to improve their work.
8 Course assessment requirements
8.1 Course assessment results are composed
Course total evaluation score = usual assessment score (attendance rate) × 30% + examination × 70%.
The general education course adopts the oral report of scientific research and innovation ideas (with reference to the National Natural Science Foundation of China bid writing) assessment method, which in itself is a special and advanced learning method Within the scope of the name of the 4 public elective courses, you can use any experimental conditions in the world, and there is no reagent drug and instrument equipment in the world that can be ordered (the United States is developed, in fact, this is the way it is), standing on the basis of the predecessors of research and development, the implementation of scientific and technological innovation and development. This is a heavy assessment method, 10 classes only come once in the later stage, 3 minutes oral report excellent credit file can be passed by 100 points, the report language can be English and Chinese, without missing classes, complete the homework and review on time the final thesis (English and Chinese, according to the standards of authoritative academic journals at home and abroad), if lackluster, can only be completed with about 70 points. Students of different departments and departments and different grades have weights to be added and subtracted. In fact, this examination method itself is a special and most advanced learning method, which can be questioned and discussed by those who arouse interest, and the teacher can immediately put forward different opinions to adjust it, of course, the teacher decides. This unprecedented level of enthusiasm is still fresh in my mind! Prepare a review of the microbiology section exams for master's and doctoral candidates in veterinary etiology (with international standards, both in Chinese and English).
8.2 Usual assessment
The proportion of the usual assessment score to the total evaluation score of the course is %. The usual assessment method and weight requirements should comply with the provisions of Table 4.
Table 4 Usual assessment methods and weights
Usual assessment type
Percentage
Purpose of assessment
Attendance
60%
Classroom discussions
20%
Classroom oral Q&A exchange
8.3 Exams
The test results are evaluated on a 100-point system; the proportion of the total evaluation score of the course is 70%, and the content of the examination is mainly the understanding and mastery of the content taught in the classroom, and the examination method is after-school homework.
9 Evaluation and improvement of teaching quality
According to the characteristics of this course, the learning effect and satisfaction of students are evaluated by means of questionnaire surveys, classroom questions and examinations, and the students are immediately randomly checked to evaluate the students' mastery and application of the content learned, and the quality analysis of the results is carried out to clarify whether the course meets the requirements of talent training. In view of the problems and deficiencies in the teaching of the curriculum, the teachers continue to revise and improve to ensure the continuous improvement and effectiveness of the quality standards of the Virology and Virology courses.
Teaching practice of professional courses
He teaches undergraduate and doctoral courses in microbiology, immunology, bioinformatics, and systems biology. From the perspective of the international vision of talent training, undergraduate courses focus on the mastery of the three basics, master's students focus on research progress, doctoral students focus on special topic reviews, have the courage to teach reform, broaden students' thinking, and strive to improve students' innovative thinking and comprehensive quality, which has received good results and is very popular. In the undergraduate professional courses, it is also taught according to aptitude, such as the 05-level biological sciences major class 1-3 of the College of Veterinary Medicine (with high admission results) "Animal Microbiology" course, arrange all students to listen to the reports of academicians in frontier fields at home and abroad, and additionally listen to professor Zhang Deli's 60-hour advanced veterinary microbiology course for preventive veterinary graduate students, which is reflected in the final exam questions. In the "Aquatic Microbiology" course of Aquaculture Class 06 Class 1-3 of the College of Animal Science and Technology, we strive to overcome the difficulties of first-year freshmen in taking this course, and later know that there is no immunology course arrangement in this major, and increase the teaching content of medical immunology closely related to microbiology according to the high level requirements of the Department of Immunology of Peking University Medical College.
The composition of a composite innovative talent training system for viral immuno-tumor information education
The cultivation of this master's degree and doctoral degree will be a good selection of admissions, opening argument, mid-term assessment and thesis defense four major passes, to open the topic argument and mid-term assessment is the most critical, the necessary modification of the topic is acceptable, the change is fatal, should do enough homework in advance, it is best not to change.
I. Theoretical System: An Important Feasible Basic Level for the Professional Training of Undergraduate, Master's and Doctoral Disciplines Scientific and technological innovation is achieved through talent training, and talent training is manifested through education and teaching practice. Scientific and technological research and development innovation follows its own laws, that is, scientific truth-seeking and technological invention. The cross-integration of modern science and technology is an important means for the development of cutting-edge cutting-edge science and technology. Therefore, the cultivation of composite innovative talents has attracted worldwide attention, and the exploration and practical value of the composite innovative talent training system of professional and technical education has been highlighted. Oncology is a difficult comprehensive profession, viruses can not replicate and proliferate without the cell host, virology is comparable to oncology, viral diseases account for 75%-80% of infectious diseases, pathogenic microorganisms are the basis of infectious diseases, immunity is resistance, immunology involves all aspects of medical life, both clinical and basic, pathology includes pathological anatomy, pathological histology and pathophysiology, is an important basic professional of clinical medicine, information exists in matter or energy, and now the importance is higher than energy, higher than matter, Informatics injects vitality into the development of medical life, and virology, immunology, and oncology are the core keys of medical life. Therefore, the frontier of viral immune tumor information has become the field of choice, and the research on the systematic biological mechanism of pig model of major respiratory virus diseases has become the direction of choice research. Teaching and research complement each other, and explore and practice the training system of composite innovative talents engaged in viral immuno-tumor information education. Long-term practice has proved that only the cross-integration of virology, immunology, oncology, and informatics can facilitate the teaching practice of general knowledge and professional education, and only facilitate the centralized training of composite innovative talents in the same physical space under the same tutor's name, and the system includes undergraduate general education to divert some talents, undergraduate professional education selection talents, through science and technology, professional learning, graduation thesis completion, and then combined with master's and doctoral training to create composite talents.
Second, the technical system: the master's and doctoral disciplines to cultivate objective practical operation methods and means of measures to promote talents, the results of comprehensive ability improvement, interdisciplinary science and technology, interdisciplinary or transfer professional learning to complete the graduation dissertation; undergraduate professional education to lead the selection of talents, science and technology or the completion of graduation dissertations; master's and doctoral students advanced learning to cultivate talents. General education for undergraduate students with viral immuno-oncology information, some interdisciplinary science and technology innovation or transfer majors; veterinary medicine, animal science, aquaculture, biological sciences (animal direction), biological sciences, biotechnology, biological engineering undergraduate professional education, can be combined with the above general education, or combined with the corresponding professional standard education of the course. Undergraduate science and technology, bachelor's and doctoral dissertations were completed at the regular working meeting of the common large conference room, the common goal dry laboratory (information computer network environment laboratory), and the wet laboratory (water-containing operation technology laboratory).
III. Philosophical System: The strategic, tactical and tactical level of the professional training of the master's and doctoral disciplines (with the strategic level as the core) The undergraduate graduation dissertation, science and technology project guidance, master's and doctoral students are essentially the same. Talent selection, training, and cultivation are discussed as follows in the order of the process. First of all, the master's and doctoral degrees are safe, healthy and happy to learn, as the principle of talent training in order, it is possible to race between turtles and rabbits, always grasp the opportunity, and overall achieve excellent results. Secondly, talent, foundation, speculation (thought), experimentation (design), epiphany, and hard work are the 12-word key to scientific and technological research and development, that is, the 12-word key to the selection, training and cultivation of outstanding scientific and technological talents, especially scientists or technical experts, the master's and doctoral degrees are naturally no exception, outstanding undergraduate achievements are enough to outperform ordinary doctoral students, and outstanding doctoral student achievements may win the Nobel Prize. Scientific research has found that the nature of matter, energy, information in nature (phenomena, essences, laws of motion), technological invention and creation are highly intelligent mental activities, and talent and even genius are necessary. The foundation is the guarantee for the improvement of professional skills in the discipline. Speculation is a highly intelligent mental activity, with comprehensive (analysis, judgment) response, innovative thinking (including logic, image or chaotic thinking) is the most prominent, thinking is the result of highly intelligent brain speculation activities, technological inventions focus more on thought. Experimental design is a means of scientific research and technological invention, but scientific research emphasizes experimentation and technological invention emphasizes design. Epiphany is the accumulation of major and difficult scientific and technological problems that have not been solved for a long time, and only a very small number of scientific and technological research and development personnel have it, and the number of times is extremely limited. At the critical moment, not only the spirit of hard work, but also the conditions for hard work, in order to give priority to achieving major scientific and technological achievements, safe, healthy and happy learning is aimed at striving after epiphany.
The core of the 12-word key to scientific and technological research and development is experimental design, which requires standing on the shoulders of giants, that is, mastering the dynamics of science and technology and key details, in order to condense and raise major scientific and technological problems, and English expression and communication as a scientific and technological Esperanto is particularly important. In addition, through innovative thinking, ideas and techniques for solving problems are proposed, and experimental design schemes are given. Third, the core thrust of student science and technology research and development innovation SCI papers is design: good atmospheric conditions, experimental design schemes, implementation record analysis, hypothesis refinement and sublimation. Finally, the tutor himself does not talk about the price, does not talk about the conditions, based on reality, and creates miracles; the students are required to aim high, be down-to-earth, be willing to be bitter, and bravely climb the peak. The formation of this spirit is the result of the casting of the soul!
Viral immuno-tumor information 4 professional science and technology frontier cross-integration teaching and research, general education comprehensive ability improvement of teaching practice and compound innovative talent training system practice
A teaching system for the cultivation of innovative talents in the interdisciplinary disciplines of virus-immunology-tumor-bioinformatics has been established. In the past, the teaching of virus, immunology, oncology and bioinformatics was carried out in isolation, and there was no organic cross-integration, and now a new teaching system for the training of innovative talents in the interdisciplinary discipline of virus-immunology-tumor-bioinformatics has been established to facilitate the cultivation of innovative talents, and the selection and training of undergraduate general education courses, professional courses, master's and doctoral students form a one-stop link. Undergraduate students of general studies who generate professional interest, their science and technology innovation projects, graduation dissertations and preventive veterinary medicine, animal biotechnology, bioinformatics 3 professional master's and doctoral training combination, that is, at least 3 hours late every weekend in the same large conference room to participate in the graduate work meeting, different professional disciplines cross-substantive integration, experimental operations are also implemented together in the common space, to cultivate composite innovative talents. Specifically, it includes the theoretical system, technical system and philosophical system: the theoretical system is at the level of the important feasibility of the professional training of the master's and doctoral disciplines; the technical system is at the level of objective practical operation methods and means and measures for the training of the master's and doctoral disciplines; and the strategic, tactical and tactical level (with the strategic level as the core) for the training of the master's and doctoral disciplines.
Major contributions
1. Engage in front-line teaching work, boldly explore ways to improve teaching quality in teaching practice, attach importance to the cultivation of students' comprehensive quality and innovative thinking, and establish a set of teaching teaching, teaching assessment and teaching feedback improvement system, which plays a vital role in the teaching practice of improving the comprehensive ability of viral immune tumor information and general education. The teaching practice of microbiology, virology, bioinformatics, and systems biology follows a similar pattern, and some adopt a similar style.
2. The new 4 frontier courses of medicine and biology for the undergraduates of the university have been insisting on teaching, generating professional interest in general studies undergraduates, and their science and technology innovation projects, graduation degree thesis and preventive veterinary medicine, animal biotechnology, bioinformatics 3 professional master's and doctoral training combination, that is, at least 3 hours every weekend in the same large conference room to participate in the graduate work meeting, different professional disciplines cross-substantive integration, experimental operations are also implemented together in the common space, cultivate composite innovative talents, A lot of effort has been poured into forming an effective whole system.
3. Took the lead in carrying out the pathogenesis analysis of the system biology of the pig model of major respiratory virus disease and the exploration of the function of natural immune genes related to major diseases, established the systematic biology analysis system of the molecular evolution network of the pig model of major respiratory virus disease, and the technical support system for the bioinformatics and computational systems biology research of livestock and poultry and viruses, and published more than 20 corresponding author papers in SCI journals such as Cell Death and Disease, which has always focused on" The original direction of the systematic biological mechanism research of pig model for major respiratory virus diseases was approved by the chief scientist for the "Twelfth Five-Year Plan" (2011.01-2015.12) of the Ministry of Science and Technology of the Ministry of Science and Technology, the first batch of preparatory projects in the rural field of the National Science and Technology Plan "Analysis of the Biological Mechanism of Major Respiratory Virus Diseases and Key Gene Screening, Identification and Function Research" (Basic Research Category, No. NC2010CD0178, Lead Application Unit: Northwest A&F University, Recommended Expert: Academician Chen Runsheng, Academician Cao Xuetao, Professor Li Mengfeng, Professor Ma Dalong, and technical leader: Zhang Deli) have strong strength in this field, providing solid and continuous support for the practice of this set of general education teaching and talent training methods.
The selection of teaching materials and reference materials and the purpose and reasons for the course are shown in Appendix A and Appendix B respectively.
Appendix A
(Informative Appendix)
Selection of teaching materials and reference materials
Usage of teaching materials:
1. Editor-in-chief of Xiaoming Gao. Medical Immunology. Beijing: Higher Education Press, 2006
2. Wu Wutong, editor-in-chief. Biotechnology Pharmacology. Beijing: Higher Education Press, September 2003
Appendix B
Purpose and rationale for the course
Course Objectives:
Through learning and preliminarily mastering the basic theories, experimental techniques and basic knowledge of immunology and biopharmaceuticals, preliminarily understanding the research progress, existing problems, development countermeasures and development prospects of immunology and biopharmaceuticals, it plays a role in stimulating interest, mastering knowledge, understanding the situation and broadening the thinking, and can independently consult domestic and foreign literature for in-depth study, and even embark on the road of relevant professional scientific research.
Reasons for starting:
Immunology is an important backbone bridge course for life sciences and biotechnology related disciplines, which is closely related to the daily healthy life of human beings, so it is important to learn immunology courses well. Immunology is the frontier discipline of life science and medical development, its development is changing with each passing day, has now become an independent discipline, and biochemistry, molecular biology, cell biology, genetics and omics, etc. interpenetrating, mutual promotion, rapid development, in the past 20 years has made a series of breakthrough achievements. Since 1901, 22 immunologists have been awarded the Nobel Prize in Medicine and Physiology 15 times.
Immunology is closely related to biopharmaceuticals, especially biologics. Existing biological drugs are mainly biological products, including interferons, interleukins, tumor necrosis factor, hematopoietic cytokines, growth factors, therapeutic hormones, soluble receptors and adhesion molecule drugs, hemolytic drugs, blood products, blood substitutes, therapeutic enzymes, antibodies, vaccines and their adjuvants, and nucleic acid therapy.
Classification of biological drugs in the new century: (1) gene drugs: therapeutic genes, antisense nucleic acids and ribozymes, etc.; (2) genetically engineered drugs: recombinant biologically active proteins, polypeptides and their modifiers manufactured by genetic engineering and protein engineering techniques, such as therapeutic proteins, antibodies, vaccines, concatenants, fusion proteins and soluble receptors; (3) natural biochemical drugs: natural biochemical active drugs of animal, plant, microbial and marine biological sources; (4) synthetic or semi-synthetic biological drugs.
Biological products (Biologicals) is a large category of biological drugs, which are prepared by using ordinary or obtained biotechnology such as genetic engineering, cell engineering, protein engineering and fermentation engineering, and various animal and human tissues and liquid biological materials for human disease prevention, treatment and diagnosis. In essence, biological products generally refer to pharmaceutical products from blood, vaccines, toxins and immune preparations, excluding traditional biological drugs such as hormones, enzyme preparations and plant metabolites, but including new biological products, that is, proteins, polypeptides, enzymes, hormones, vaccines, monoclonal antibodies and cytokine drugs and their modifiers produced using recombinant DNA technology and protein engineering technology.
The university does not offer a public elective course on "Immunology and Biopharmaceuticals", but is now planning to open a new course at the request of students, and teach it in combination with actual work: taking vaccines as an example to elaborate on the whole process of research, development and industrialization of biological products, so that students can have an in-depth understanding of these three processes and their details from the overall situation; adding the latest contents such as omics, bioinformatics and systems biology, genome and post-genome drug research and development that are not available in conventional courses.
The main lecturer Zhang Deli has been studying and engaged in immunology and biopharmaceutical research for a long time, and is now a professor and doctoral supervisor of the Department of Preventive Veterinary Medicine of the College of Veterinary Medicine of our university introduced from Tsinghua University, and teaches undergraduate courses "Veterinary Microbiology", "Animal Microbiology" and "Aquatic Microbiology and Immunology", and is well qualified to teach the newly opened public elective courses. Zhang Deli holds a bachelor's degree in economics, medicinal uses and laboratory animals from Jilin Agricultural University (1984), a master's degree in virology and immunology from plastered Veterinary University (now Jilin University/Academy of Military Medical Sciences) (1987), and a doctorate in viral immunology and tumor pathology from China Agricultural University/Fourth Military Medical University (1999). From 1992 to 1993, he was a visiting scholar at the State Key Laboratory of Viral Genetic Engineering, Institute of Virology, Chinese Academy of Preventive Medicine. Postdoctoral Fellow in Medical Immunology and Bioinformatics, Peking University (2002). Postdoctoral Fellow in Bioinformatics and Systems Biology, Tsinghua University (2005). Tsinghua University assessed as a researcher (professor) (2004). He was invited to the Special Report on Medical Genome of the 21st Century Medical Forum between China and the United States, the Special Report of the Beijing-Hong Kong Frontier Symposium on Life Sciences, the Conference Report of the Young Scientists Forum of the Chinese Genetic Society and the Special Report of the Young Scientists Forum of the China Association for Science and Technology "Bioinformatics and Evolutionary Computing". In 2002, he won the Poster Award of the 7th International Human Genome Congress, which was the first time that Chinese scientists won the award at the International Human Genome Congress. In 2003, he won the first prize of the Excellent Academic Paper Award of the China Postdoctoral Life Science Symposium and Academician Forum. He has won the second and third prizes of the military's scientific and technological progress, and has won the national second-class new drug certificate and production approval number. Two important landmark identification results in vaccine development were obtained: (1) Jingkeden Zi 20040602: the first successful development and long-term wide application of a safe and efficient mink enteritis virus cell culture inactivated vaccine; (2) the general post-certification 2002121008: the first discovery and successful replication of malignant rhabdomyoidoma (MRT) in model animals, which provided an opportunity to elucidate the mystery of its origin; and the occurrence and development of MRT were initially elucidated from the perspective of chromosomal genetic variation. From a comparative medical point of view, the histiocyte origin of MRT is revealed, the problem of oncogenic toxicology experiments of passaged cells (CCL) for vaccine preparation is solved, and the relationship between genetic variability and carcinogenicity (tumor) is revealed.
Course group instructor information
Subjects are on other courses
Bachelor's degree in veterinary medicine, animals, aquatic microbiology, virology, bioinformatics, systems biology professional courses teaching workload is full, with the interdisciplinary scientific research work of systematic microbiology, the establishment of "virus-immunology-tumor-bioinformatics interdisciplinary innovative talent training teaching system"
Biography:
Zhang Deli, male, born in December 1962, from Shanyang County, Shaanxi Province
Xinong University has introduced high-level talents to teach doctoral supervisors
Faculty member ( Researcher ) , Department of Nutrition and Food Hygiene , Peking University Medical College
Tsinghua evaluates researcher/professor qualifications
Tsinghua University of Engineering peking university medical double postdoctoral fellow
Qualification of senior research scholar in the United States by the National Scholarship Council
In 2004, the academic report of Peking University Professors' First Open Competition for Professors inside and outside the university was approved
In 2005, Nankai University Outstanding Three Talents Professor of The School of Physical Sciences was recruited
2016 China Top 100 Financial Blogs Competition Ranked 211th
2002 Poster Award, 7th International Congress on the Human Genome (recommended HUGO member)
2003 China Life Science Postdoctoral and Academician Forum Outstanding Academic Paper Award First Prize
2001 China 100 Outstanding Doctoral Dissertation Award nominations
The master's degree thesis was published in the Chinese and English editions of "Science in China" series B and "Science Bulletin" at the end of the 1980s, was included in the survey object of the structure of China's outstanding scientific and technological talents, and was serialized in the journal of the International First-level Society for the Standardization of Biological Products, and was awarded a membership certificate by the American Association for the Advancement of Science (AAAS) free of charge, creating huge social and economic benefits, and at that time, only the learning units received net profits of Yu million yuan per year
Passed the college English exemption examination, won the first place and first prize in the university English competition, and the bachelor's degree thesis was published in the journal of the professional branch of the national first-level society in the 1980s
In high school, when I was good at solving difficult problems, mathematics, physics and chemistry, there were only 3 people in the same grade who passed the same grade, and I was the first place every time and far ahead
Now the "Research Direction of Systematic Biological Mechanism of Pig Model for Major Respiratory Viral Diseases" has cultivated innovative achievements in cultivating talents:
• Pioneered the analysis of the pathogenesis of pig models of major respiratory virus diseases and the exploration of pig models for the study of natural immune gene function related to major diseases.
• A systematic biological analysis system for molecular evolution networks of pig models of major respiratory virus diseases has been established,
• and technical support system for bioinformatics and computational systems biology research on livestock, poultry and viruses,
• At Cell Death and Disease, Scientific Reports, Oncotarget, Plos One, Proteins (Structure, function & Bioinformatics), Vet Microbiol, J Clin Virol and BMC Infect Dis and other SCI journals have published more than 20 corresponding author papers (the cumulative impact factor exceeds 40 nearly 50),
• Always focus on the original direction of "Research on the Systematic Biological Mechanism of Pig Model for Major Respiratory Virus Diseases",
• For original research, the chief scientist applied for the approval of the Ministry of Science and Technology "Twelfth Five-Year Plan" (2011.01-2015.12) National Science and Technology Program in the rural field of the first batch of preparatory projects in the rural field "major respiratory virus disease pig model system biological mechanism analysis and key gene screening, identification and functional research" (basic research category, no. NC2010CD0178, lead application unit: Northwest A&F University, recommended experts: Chen Runsheng, Cao Xuetao, Li Mengfeng, Ma Dalong, technical leader: Zhang Deli), It shows that it has strong strength in this field.
• As a core backbone, he is currently participating in the national R&D program "Research on the Mechanism of Cross-species Transmission of Zoozooviral Virus Pathogens" Task (Topic) 7 (No. 2016YFD0500306).
Signify the results
1. Zhang Deli, Li Liujin, Huang Gaosheng, Xia Gengtian, Gao Buxian, Liu Shanggao, He Xuyu, Fang Fude, Xu Yirui. "Cytoline chromotype analysis and carcinogenic safety evaluation and rhabdomyotid origin for the preparation of military dogs vaccine" passed the appraisal of medical and health science and technology achievements organized by the General Logistics Department of the Chinese People's Liberation Army in October 2002, and obtained a high score, and won the military logistics science and technology achievement appraisal certificate (No. 2002121008)
2. Zhang Deli, Yu Yongren, Xia Gengtian, Han Huimin, Yin Zhen, Wang Shuzhi, Liu Shanggao. "Development and Application of Mink Parvovirus Inactivated Vaccine" Obtained the national production approval number (Ministry of Agriculture (99) Agriculture and Animal Husbandry (Pharmacy) Zi No. 40) to produce huge social and economic benefits, and obtained the National Class II New Drug Certificate (Ministry of Agriculture (98) New Veterinary Drug Certificate No. 13) as if passing the appraisal (Beijing Municipal Science and Technology Commission approved registration number: Jingkeden Zi 20040602 in April 2004), can participate in the first prize of the National Science and Technology Progress Award (Ma Chuan Poverty Immunization Theory Breakthrough Person, Recommended by Academician Shen Rongxian, winner of the First Prize of National Invention Award and winner of the Highest Technology Award of Heilongjiang Province)
3. Zhang Deli, Li Liujin, Huang Gaosheng, Bai Xiaohong, Gao Buxian, Liu Shanggao, He Xuyu. "Research on the Origin of Rhabdomyoid tumors---- Experimental Study on Malignant Rhabdomyoid Tumors Produced by Nude Mice with High Rate of Variability BHK-21 Cells" was identified by the Military's Medical and Health Science and Technology Achievements Organized by the Joint Logistics Department of the Beijing Military Region in January 1999 (it is considered an important breakthrough achievement, and 7 medical pathology review experts unanimously recommend the first and second prizes for military scientific and technological progress)
Academic achievements
1. Obtained two important landmark identification results: (1) Jingkeden Zi 20040602: the first successful development and long-term wide application of a safe and efficient mink enteritis virus cell culture inactivated vaccine; (2) general forensic 2002121008: the first discovery and successful replication of malignant rhabdomyoidoma (MRT) in a model animal, which provides an opportunity to elucidate the mystery of its origin; and preliminarily elucidates the occurrence and development of MRT from the perspective of chromosomal genetic variation. From a comparative medical point of view, the histiocyte origin of MRT is revealed, the problem of oncogenic toxicology experiments of passage cell lines is solved, and the relationship between genetic variability and carcinogenicity (tumor) is revealed. In the field of biological circulation and breeding, the theoretical and technical system of alternating biological cycle breeding in the advantages and disadvantages of viral cell genetic evolution has been preliminarily established and applied in practice, which is precisely related to the development of high-efficiency mink parvovirus vaccine, the technological innovation of recombinant plasmid transfection of pox vaccine, the safety evaluation of cell line carcinogenic toxicology, the establishment of heterogeneous tumors in vitro experimental transformation phenomenon and the initial revelation of the mystery of rhabdomyotids, which has extensive scientific guidance and practical significance.
2. Took the lead in implementing the research of electronic cloning of new human genes, and made important progress in the separation of new methods of gene (including non-coding RNA) recognition and functional genes: a method of discovering new genes in humans and animals from the perspective of computer software analysis, artificial intervention analysis and combination with experimental biology was established, and proved that it is an effective way to accelerate gene cloning and identification; the algorithm research of collaborators on new gene recognition and regulatory region prediction significantly improved the accuracy of gene prediction and promoter prediction. Preliminary cooperation to establish automated electronic cloning software for new human and animal genes; electronic cloning of more than 100 new human genes, but also the use of computers to identify 800 new human gene candidates, some of the gene coding sequences have been experimentally confirmed and cited, several of which have shown obvious biological function activity in animal experiments; found that there are various types of human gene pattern reference sequences (REFSEQ) published by the NCBI Genome Annotation Project in the United States. This result suggests that NCBI's REFSEQ database should be used with caution.
3. Always focus on the original direction of "Research on the Systematic Biological Mechanism of Pig Model for Major Respiratory Virus Diseases", first carry out the pathogenesis analysis of the system biology of pig models of major respiratory virus diseases and the exploration of pig models related to major diseases, and have established a systematic biology analysis system of molecular evolution networks of pig models of major respiratory virus diseases, as well as a technical support system for bioinformatics and computational system biology research of livestock and poultry and viruses.