Collect astringents
Any drug whose main function is astringent is called astringent. This kind of drug has a sour and astringent taste, and has the effects of sweating, antidiarrhea, sperm, urinary condensation, cough and so on. It is used to treat self-sweating, night sweats, diarrhea, prolapse and other symptoms of slippage caused by long-term illness and lack of vitality. The Compendium of Materia Medica records that "when it is removed, it is scattered and not collected, so it is used with sour and astringent medicine to absorb its dissipation.".
Astringent solidity is a method of emergency treatment of symptoms, clinically often used with tonic drugs, taking into account the symptoms and solidifying the root causes, according to the specific symptoms, with other drugs. Most of these drugs contain tannic acid.
Pentaplus contains 70-80% saddle. Tannic acid acts on the mucous membrane and wound ulcers to make the protein precipitate and coagulate, becoming an insoluble compound, forming a film that covers the affected part. It also has the same effect on secretory cells, making them dry, the surface of solid tissue is tight, small blood vessels are compressed, or convergence causes blood to coagulate, thus achieving hemostasis. For mild intestinal inflammation, its astringent effect can also stop diarrhea. In addition, it has antiseptic effect and is often used for anti-inflammatory. Therefore, it is more suitable for bleeding, diarrhea, intestinal ulcers, hyperhidrosis and mucosal inflammation, but it should be avoided for acute inflammation, because it can make the surface of inflammation scab, cover the infection, and hinder the growth of normal tissues. If it is absorbed in large quantities, it can harm the liver. Pentaploid in vitro experiments have bacteriostatic and bactericidal effects on a variety of cocci (staphylococcus, streptococcus) and bacilli (typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, aerantopurism, E. coli). Its antibacterial effect is not due to acidic effects, but due to the tannic acid coagulation protein contained, as well as other components.
Pomegranate skin contains tannin 10.4-21.3%. Clinical observations have proved that pomegranate peel alkali and tannin binders have a good deworming effect, because tannin can turn alkaloids into insoluble and difficult to absorb compounds, thereby fully exerting effect on intestinal parasites. Pomegranate skin in vitro tests have antibacterial effects on green pus stalk seedlings, bacterium dysentery, typhoid bacillus, etc., and also have different degrees of inhibition of a variety of skin fungi, as well as the effect of anti-influenza virus. Pomegranate skin has an astringent astringent effect, which is suitable for long-term diarrhea and diarrhea, bloody prolapse in the stool, etc. The "Compendium of Materia Medica" says: "Stop the blood under the diarrhea, prolapse, collapse, and take down." It is effective in the treatment of acute and chronic dysentery in modern clinics.
Red stone resin is a monoclinic crystalline multihydral kaolin, when the red stone resin in 150 ~ 2000C, there are still two molecules of water, that is, become kaolin, containing aluminum silicate and iron oxide, etc., the mucous membrane has an astringent and adsorption effect, can absorb toxic substances in the digestive tract, bacterial toxics and food abnormal fermentation products, and protect the digestive tract mucosa. It can also stop bleeding in the astringent intestines, cure long-term diarrhea and blood in the stool, etc. End-of-research topical treatment After the ulcer carbuncle ulceration for a long time without closing the mouth, it can produce muscle closure. The "Materia Medica" says: "The Lord Jaundice, Draining Intestinal Boils, Pus and Blood, Yin Erosion, Diarrhea White, Evil Qi Carbuncle Swelling, Hemorrhoid Hemorrhoids, Scabies and Scabies Itching.". The pharmacological effects of modern research are consistent with the records of ancient books.
Golden cherry seeds contain tannin, and their decoction has the strongest bacteriostatic effect on Staphylococcus aureus, followed by Proteus, Typhoid Bacillus, and Fochsley dysentery rod
Bacteria also have inhibitory effects; The inhibitory effect on the influenza virus PR8 strain is strong, in the aqueous solution of 1:3200, the influenza virus still has an inhibitory effect, the treatment of rabbit experimental atherosclerosis with golden cherry seed can reduce serum cholesterol and β lipoprotein, liver fat concentration and atherosclerosis degree are mild.
Umeethanol infusion, decoction and powder have significant antibacterial effects on gram-positive bacteria, E. coli, dysentery bacillus, Proteus, typhoid bacillus, paratyphoid bacillus, Pseudomonas aeruginosa, Vibrio cholerae, Bacillus subtilis and Humanoid tuberculosis bacillus. Ume decoction also inhibits pathogenic fungi such as Ringworm auris, Flocculent Epidermal Ringworm, and Gypsum-like Sporphyllus in test tubes, and can reduce the number of deaths in guinea pigs with egg whites and histamine shock animals. Clinical A type ultrasound examination, oral Ume has the effect of shrinking the gallbladder, the dose increases, the gallbladder contraction and pelagic effect are also more obvious, so it is suitable for cholelithiasis, cholecystitis and biliary roundworm.
Schisandra has a significant effect on the central nervous system, cardiovascular and respiratory systems, digestive system and lowering alanine aminotransferase, Schisandra can enhance the excitant hazy main inhibition process of the cerebral cortex, promoting the balance of the two processes. The "Compendium of Materia Medica" records: "Tonic and fatigue make the body happy, the eyes are bright, the five organs are warm, and the bones are strengthened." The medicine of the motherland believes that Schizandra is a strong tonic for deficiency and vitality, which may be related to the adjustment of central nervous system functions. The antitussive effect of Schizandra is consistent with the lung qi and asthma cough recorded in Chinese medicine books.
antiperspirant
Ephedra root Floating wheat Glutinous rice root
Antidiarrheal drugs
Umeha (attached: Navy green fruit) pomegranate skin, pomegranate skin, nut and bean, millet shell, white alum, red stone fat, Yu yu grain
Sperm fixation, urinary shrinkage, anti-belt medicine
Dogwood Mulberry Cockroach Nootropic Ren Lotus Seed Lotus Seed Solid Raspberry Golden Cherry Seeds Ginkgo Sea Mantis Slug Night Close Hedgehog Skin
Example: First, solid astringent medicine
(1) Schisandra "Benjing" is the ripe fruit of the perennial deciduous vine Schisandra of the Magnolia family. Mainly produced in Liaoning, Jilin, Heilongjiang, Shanxi and other places,
For medicinal purposes, steaming or intensive burning.
Aliases: Northern Schisandra, Liao Wuwei.
Prescription names: Schizandra, Northern Schisandra, Southern Schisandra.
Medicinal part; Ripe fruit.
Taste: sour, sweet, warm.
Returning to the meridians: into the lungs, heart, kidney meridians.
Features; It is beneficial to the vitality, replenishes the kidneys and nourishes the heart, and astringents and astringent.
Indications and Applications:
1. It is used for fatigue and sweating caused by qi deficiency and injury, shortness of breath, palpitations, dry mouth, etc., as well as breath deficiency and wheezing cough. If the pulse is scattered, it is compatible with ginseng and mai dong, and is used for qi and jin injuries, sweating and tiredness, wheezing for a long time, shortness of breath and phlegm, as well as insufficient qi and yin, palpitations and pulse deficiency.
2. It can not only supplement the lungs and kidneys, but also can absorb lung qi and stop wheezing and coughing, so in addition to being suitable for lung weakness and wheezing cough, it is also suitable for wheezing cough of insufficient lungs and kidneys. It is often compatible with dogwood, cooked ground, etc., such as Yuqi pills.
3. It is used for body weakness and self-sweating, night sweats, sperm retention, frequent urination, long-term leakage and other slip and non-solid symptoms, this product has the function of astringent and astringent. For clinical application, appropriate drugs must be formulated separately. For example, it is often used with cypress kernels and oysters; Treatment of sperm loss, urinary frequency, often with mulberry mantis, nootropic kernels; The treatment of long-term diarrhea does not stop, and is often used with psoralen and nuts.
Dosage: 3-9 g. Use note: This product is sour and astringent, where the appearance of evil is not solved, there is real heat inside, the first cough, measles first onset should not be used. Resources:
Contains Schisandra, malic acid, citric acid, tartaric acid, vitamin C, fatty oils, volatile oils, sugars, resins, etc. Northern Schizandra can enhance the excitation and inhibition process of the central nervous system, and make it tend to balance, so it can improve work efficiency and reduce fatigue. It can regulate the cardiovascular system and improve blood circulation. Has an excitatory effect on breathing. It can also regulate the secretion of gastric juice, promote the secretion of bile, and stimulate the uterus and lower blood pressure. The four components of Schisandra ethyl pigment can significantly reduce the elevation of animal tro-propion amino acid caused by carbon tetrachloride and have a certain protective effect on liver cells. Clinically, it is often used as a pill and powder for jaundice-free and prolonged slow hepatitis.
(2) Golden Cherry Seed "Shu Bencao" is the ripe fruit of the golden cherry seed of the evergreen climbing shrub plant of the Rosaceae family. Produced in Guangdong, Sichuan, Yunnan, Hubei, Guizhou and other places.
Rub off the spines, peel off the cores, and dry them for later.
Aliases: prickly pear, sugar jar, lantern fruit, wild pomegranate.
Prescription name: Golden Cherry Blossom.
Medicinal part: ripe fruit.
Taste: sour, astringent, flat.
Meridians: Kidney, bladder, large intestine meridians.
Function: Solidifying sperm and shrinking urine, astringent intestines to relieve diarrhea.
1. This product has the effect of fixing sperm and shrinking urine, which is suitable for kidney deficiency caused by the frequency of sperm loss and urination, enuresis and other evidence, and can be used with Qi Shi. It can also be used with boiling cream alone and taken continuously. Or with silk seeds, mulberry mantises and the like.
2. It can fix the intestines and stop diarrhea, can be used for spleen deficiency and long-term diarrhea, and is often used with ginseng, white art, yam, poria and so on. In addition, the vaginal discharge of the spleen and kidney deficiency can also be used in the above matching method, which has a stop-band effect. Dosage: 6-18 g.
Resources:
The product can promote the secretion of gastric juice and help digestion, but it can reduce the secretion of the intestine. Therefore, it has an antidiarrheal effect. It has been reported that taking it internally with 10% gold cherry blossom concentrated decoction has a certain effect on the treatment of mild uterine prolapse. In vitro tests, a diluted water-soluble solution of 1:3200 of tassel has an inhibitory effect on influenza virus.
(3) "On medicinal properties" In order to make the ripe fruit of the deciduous tree plant of the Junzi family, it is native to India, Malaya, and Myanmar, and is now mainly produced in Yunnan and Guangzhou, China
East, Guangxi and other places. Harvested in July-August, dried, raw or simmered, and pitted if pulp. Aliases: Khalil, Khalil.
Prescription names: Khun Zi, Khun Khī Đồồi, Khun Khun Kh
Sexual taste: bitter, sour, astringent, flat.
Meridian: Lung, large intestine meridian.
Function: Astringent intestinal antidiarrhea, lung and throat.
1. The simmering of this product can absorb the large intestine, stop diarrhea, diarrhea for a long time, and slip and discharge. For diarrhea abdominal pain and heat, it is used with huanglian, wood fragrance and licorice; For those who have been diarrhea for a long time and are cold, use it with dried ginger and meat and beans. If diarrhea is prolonged, when the qi and yin are injured, it must be used with drugs that are beneficial to the qi and spleen and nourish the yin, such as dang ginseng, white art, yam, etc., such as real people to nourish the dirty intestines.
2. It can retract the lungs and pharynx, and is suitable for evidence such as lung weakness and wheezing cough, or long-term cough loss. The treatment of lung weakness and wheezing cough can be compatible with ginseng, mai dong, schisandra and so on. It is used to treat phlegm fire lungs, long-term cough aphasia and melon wilting, Sichuan shellfish, orange stem and so on.
Dosage: 3-9 g.
References: Has a certain antibacterial effect and a strong astringent effect.
(4) Qianshi "Benjing" is the seed kernel of the annual aquatic herb of the water lily family, which is mainly produced in Hunan, Jiangsu, Anhui, Shandong and other places. Peel the medicine
Take the kernel. Set aside for sun drying.
Prescription names: 芡實, 南芡實, 北芡實.
Medicinal part: seed kernel.
Sexual taste: sweet, astringent, flat.
Attribution: Spleen, kidney meridian.
Function: Healthy spleen and antidiarrhea, kidney astringent, stop the belt. Indications and Applications:
1. This product can strengthen the spleen and stop diarrhea, can be used for spleen deficiency for a long time diarrhea, often with the same use as the party ginseng, bai shu, poria and other spleen.
2. It has the effect of fixing kidney astringent. Suitable for kidney qi deficiency. Sperm loss, premature ejaculation, and frequent urination caused by insufficiency are often used together with silkworm seeds, mulberry mantises, golden cherry seeds, etc.
3. Can converge stop band, can be used in the humid tropics or under the spleen and kidney weakness. If the treatment of wet tropical, white band yellow, often with white fruit, yam, yellow cedar and other uses. If the spleen is weak and wet, it is mostly used with Bai Shu, Dang Ginseng, Golden Cherry Seed, Sawa, etc.
Dosage: 9-15 g. Resources:
Contains protein, fat, carbohydrates, calcium, phosphorus, iron, riboflavin, ascorbic acid.
(5) The Dogwood Sutra removes the pulp of the core of the small deciduous trees of the family Dogwood. It is produced in Zhejiang and Anhui, Henan, Sichuan, Shaanxi and other places.
It is used medicinally, or steamed, or steamed with wine.
Aliases: mountain meat, meat, jujube skin.
Prescription name: sweet potato meat, net meat, date skin.
Medicinal part: pulp.
Taste: sour, astringent, sweet, warm.
Attribution: Liver, kidney meridians.
Function: Tonify the liver and kidneys, sweat collection and removal.
1. Tonify the liver and kidneys, used for liver and kidney deficiency, sperm loss caused by non-solid sperm, night sweats, frequent urination, low back pain, dizziness, collapse and leakage and internal wind germination and other evidence, such as Liuwei Dihuang Pill.
2. Sweat collection and solidification, used for the violent detachment caused by the death of the yang of the great sweat, the floating of the yin and yang, or the deficiency of yin and yang. Due to the slower medicinal power, it is advisable to use a larger amount of heavy evidence, and use it with ginseng, appendages, keel, oysters and the like.
Dosage: 6-12 g. Can also be reused up to 30 grams.
References: Diuretic and hypotensive effects. In vitro tests can kill ascites cancer cells in mice. For the decline of white blood cells caused by chemotherapy and radiation therapy, it has the effect of elevating it, and the antibacterial test has an inhibitory effect on dysentery bacillus, Staphylococcus aureus and some skin fungi.
(6) The Mulberry Mantis is the egg sheath of the mantis of the insect mantis of the family Mantis family. There are many sericulture areas in southern China. Commonly known as mantis. Steam in medicine, or soak in boiling water and dry
Dry, mostly used or fried with bran.
Aliases: knife mantis, old dove pus, mantis.
Prescription name: Mulberry mantis.
Medicinal part: egg sheath.
Sexual taste: sweet, salty, astringent.
Features; Supplement kidneys and help yang, solidify sperm and shrink urine.
1. This product can tonify kidney solidification and urine contraction, mainly used for enuresis caused by kidney qi instalment, frequent urination and premature ejaculation, especially for pediatric enuresis, often with nootropics, silk seeds, astragalus and other common uses.
2. It has the effect of tonifying the kidney and helping the yang, often with goji berries, Bayan Tian, Xian Mao, Xian Ling Spleen and other evidence for the treatment of kidney deficiency impotence. Dosage: 3-9 g. Use note: This product helps the yang to be solid, so the yin deficiency is more fire, the bladder is hot and the urination is frequent.
(7) Ephedra Root "Bielu"
It is a perennial herbaceous shrub of the ephedra family, the root of ephedra, and the root of ephedra.
Prescription name: Ephedra root.
Medicinal part: root.
Taste: sweet, flat.
Attribution: Lung meridian.
Features; Antiperspirant.
This product is dedicated to antiperspiration, yin deficiency night sweats can be applied, such as oyster scatter; Cure yin deficiency night sweats, often with schisandra, cypress kernels, oysters, etc.; Treatment of postpartum sweating, often with astragalus, angelica, etc.; Qi deficiency and self-sweating are often accompanied by astragalus and white technique.
Use note: This product is dedicated to anti-sweating, and it is forbidden to use it for those who have evil spirits.
(8) Floating Wheat "Materia Medica"
It is an immature fruit of wheat, an annual herb of the family Poaceae. Produced everywhere. It is better to take the water to pan it and float it.
Prescription name: Floating wheat.
Medicinal part: immature fruit grains.
Taste: sweet, dry.
Guijing: Heart Sutra.
Features; Relieves sweat, removes heat, nourishes qi and calms the mind.
1. For self-sweating, night sweats. This product can be sweet and beneficial, cool can remove heat, and has antiperspirant effect, where the yang deficiency sweating, yin deficiency night sweats, can be applied. If the oysters are scattered, that is, this product is used with oysters, ephedra roots, and astragalus to cure the body and sweat.
2. Used for bone steaming. This product is beneficial to qi, heat removal, antiperspirant effect, so it can also be used to reduce labor fever, and is mostly used with raw land, wheat dong, ground bone skin and other yin and deficiency heat medicine.
Dosage: 15-30 g, decoction, or sautéed and charred powder. Resources:
Contains a lot of starch and vitamin B. Anthelmintics
Drugs that can kill or drive out the intestinal parasites are called anthelmintics. This class of drugs is mainly used for diseases caused by intestinal parasites (roundworms, tapeworms, hookworms, pinworms, etc.), and patients often have abdominal pain, bloating, anorexia or hunger and sickness, yellow face, emaciation, etc. Depending on the type of parasite, the drug can be selected. Taking anthelmintics can paralyze or kill the worm body, so that the worm is excreted from the body and can be fundamentally cured. For patients with physical weakness, they should first make up for it and then attack, or attack and supplement at the same time, and generally take it on an empty stomach when deworming, so as to make the drug easy to contact with the insect body and better exert the deworming effect. It is often used with laxative drugs to promote the excretion of insects. Some deworming drugs are more toxic, and pregnant women should use them with caution. Commonly used insect repellents are neem bark, gentleman, betel nut, pumpkin seeds and thunder pills.
Pharmacology (1) Repellent effect:
Ethanol extract of neem has a paralyzing effect on pig roundworms in vitro, especially pig roundworms, and its active ingredient neem is stronger than neem extract. The effect of different concentrations of neem on the head of the mantle is mildly, moderately to completely inhibited with increasing concentration, and then the activity can be gradually resumed. For the whole pig ascaris, neem appears paralyzed at high concentrations, and the low concentration has a significant excitatory effect on pig roundworms, and violent contractions can disturb the energy metabolism of the insect body, so that the insect body cannot attach to the intestinal wall and is excreted. The main site of action of Neem is the nerve ring of the head of the roundworm. After neem is given oral administration to monkeys, the drug is absorbed and distributed rapidly in the body, widely distributed, and eliminated slowly, and the concentration of the drug in the tissue is the highest in the bile, liver and duodenum, followed by the spleen and kidneys, and is evenly distributed in all parts of the brain, but the concentration is low. Multiple repeated administrations are cumulative. So that the gentleman decoction, ethanol extract can inhibit pig roundworms. The water-soluble portion of the junzi kernel extract has a paralyzing effect on the head of the pig. The insect repellent effect of junzi has nothing to do with the extraction of sugar, ash and potassium oxalate through fermentation, and its active ingredient is potassium junzi oxide, which has high deworming effect. The high concentration of the gentleman on the roundworm first excited and then paralyzed, this excitatory effect is also one of the reasons for the deworming effect.
(2) Taenia repellent effect:
Betel nut is an active ingredient of betel nut to drive away tapeworm, which has a strong paralyzing effect on all parts of the whole worm of pork tapeworm, and the effect on beef tapeworm only paralyzes the head and immature segments, and the pregnant egg segments (middle and later segments) are also affected and softened, but they are paralyzed but the effect is poor. Betel nut has a strong paralytic effect on hooked tapeworm, hookless tapeworm and short tapeworm. The pumpkin seed decoction and its proposed liquid make the middle and posterior segments of beef tapeworm thin and widen, the middle of the segments is concave and paralyzed, and the head and immature segments move freely. Dogs treated with L perchalic acid pumpkin glycine and the synthesized dl-hydrobromide pumpkin glycine can be dewormed. It has a paralyzing effect on the immature segments and mature segments of the head segment of the canine blister tapeworm and a bean tapeworm, so the whole tapeworm is often discharged. Treatment of cat tapeworm with pumpkin glycine is effective, as well as for taeniasis of the short membrane shell in mice. Thunder pills can also repel tapeworms. The "Materia Medica" records that the thunder pill "kills three insects." The main active ingredient is pyrogenol, a protease with a content of about 3% that breaks down proteins in a weak alkaline solvent (pH8). In vitro experiments have proved that the water immersion solution of Thunder Pill can kill tapeworm segments, and its role is due to the decomposition of proteins in the insect body by proteases, destroying the insect body, enlarging the stool may not necessarily find insect tablets, and its efficacy can be affirmed due to long-term fecal examination and repeated negativeness.
(3) Repellent effect:
Junzi powder does not have the effect of expelling adult mouse pinworms, but the deworming effect on mature female insects and female worms with eggs in the womb is more significant. Betel nut powder, decoction in vitro experiments on mouse pinworms have a paralyzing effect, can drive away their adult insects, but the effect is not as good as for human pinworms, betel nut powder on the larvae of mouse pinworms also have a slight effect.
(4) Hook repellent effect:
Neem root decoction on hookworm in vitro experiments, at high concentrations, can kill all. Betel nut tablets Decoction can also kill hookworms,
Some females have ruptured tail ends, exposed uterus, and curled worms. (5) The role of whipworm repellent and ginger tablet insects: betel nut decoction and combination agent (betel nut, wumei, licorice) can repel whipworms and ginger tablet insects. (6) Anti-schistosomiasis effect:
Pumpkin seeds were given to mice on the day of infection with schistosomiasis, and 28 days was a course of treatment, the prevention effect was the best, the number of worms was significantly reduced, and there was no effect on adult schistosomiasis. Pumpkin seed acetone extract, pumpkin seed acid can inhibit the growth and development of child insects, has a preventive effect, but
It cannot kill adult schistosomiasis in mice, but can only cause the amphoteric worm body to atrophy, the reproductive organs to degenerate and the number of eggs in the womb to decrease. When pumpkin glycine and tartar are combined to treat mouse schistosomiasis, the effect of taking two drugs at the same time or taking pumpkin seed ammonia acid after using tartar first is the best, and the general effect of taking pumpkin glycine and then taking tartar is generally poor. After oral administration of pumpkin glycine in mice, the liver cells showed mild atrophy or a small amount of fat infiltration in the liver, and returned to normal after stopping the drug.
(7) Other functions:
1 Treatment of botulism in animals.
Neem is administered in different routes of administration and has a therapeutic effect on animals poisoned by botulinum toxin poisoning; For mice given a lethal amount of botulism, neem is given to neem within six hours after attacking the poison, and its survival rate can reach more than 80%; More than half of the monkeys with botulism can be cured within 24 hours after attacking poisoning; It also has a protective effect on C botulism, and when combined with antivenom serum, it can significantly reduce the dosage of antivenom serum. Botulism mice have a significant antagonistic effect on the reduction of synaptic vesicles in the neuromuscular junction of the diaphragm caused by neem. Experiments have proved that the density of synaptic vesicles in the synaptic region of the neuromuscular junction of normal mice is 184±37цm2/single-dose Neem neuromuscular junction synaptic vesicles are significantly reduced, with an average density of 68±15/um2, while the average density of mice that are given neem after administration of toxins is 137±18/μm2 and 130±26/μm2, respectively, which is of certain significance for further exploring the mechanism of action of neem and botulinum toxin.
2 Antifungal. Neem bark, juniper, betel nut water immersion has an inhibitory effect on certain skin fungi in test tubes. 3 excitatory gallbladder.
Betel nut injection can obviously excite the gallbladder muscles in guinea pigs or cats and dogs in the body gallbladder, causing a strong contraction and increasing the discharge of gallbladder contents. There is no significant effect on bile secretion. Rhubarb injection can promote bile secretion, if the two are applied intermittently, for dogs or cats can increase the pressure of the total bile ducts in a short period of time, accelerate the discharge of bile, and facilitate the discharge of total bile duct stones. Betel nut has a certain contraction effect on the human gallbladder, weaker than for dogs, clinically compatible with other traditional Chinese medicines, can promote the discharge of biliary roundworms or stones. Betel nut has a choline-like effect, the effect of betel nut is similar to that of muscarinin and muscarinic, excitation of M choline receptors, and also has a choline-mimic effect on the central nervous system, cat intravenous injection of small amounts of betel nutine can cause a cortex wake-up reaction, atropine can reduce or block this effect. Betel nut also has the effect of exciting N choline receptors.
(8) Toxic effect:
Neem decoction for dogs 15 g / kg can cause vomiting, the lethal amount of rabbits is more than 40 g / kg, and the animal's tolerance to it may vary slightly depending on nutritional status and physique. Neem is administered to dogs and cats in different doses, and the decrease in blood pressure can increase with the increase in dose, blood pressure can drop sharply to zero, breathing, cardiac arrest, lung and gastrointestinal bleeding. Microscopic examination found that the bleeding was caused by damage to the blood vessel wall, causing respiratory failure mainly due to the direct inhibition of the respiratory center, and nicochamet had a slight antagonistic effect on the respiratory depression caused by it. Subacute toxicity experiments showed that neem can increase the glutase in mice and monkeys. Changes in the pathological morphology of the liver are more pronounced than in other organs, and there are deposited brownish-yellow particles on the lining of blood vessels. Pigs poisoned with oral neem tablets showed trembling limbs, strong movements, and paroxysmal convulsions. Poisoned children show unsteadiness, slurrhe, drowsiness, mydriasis, and slow response to light, which may be related to the purity of the drug, dosage form, and animal species.
Toxic doses of neem can cause general weakness (paralysis, drooping head, droopy eyelids), dyspnea in rats, pigs, dogs, and monkeys.
Symptoms such as twitching of the limbs.
Experiments have shown that neem is a neuromuscular transmission blocker that selectively acts on the presynaptic membrane. It can block the normal transmission between the neuromusculars of large and small mice, which is the direct cause of muscle weakness in monkeys and other animals. Electron microscopic observations showed that neem had significant changes in the substructure of the presynaptic membrane of the neuromuscular junction of mice and rats.
Mouse subcutaneous injection makes the minimum lethal amount of Junzi water extract 20g/kg, causing mild spasms throughout the body, and then breathing stops, so that Junzi gives dogs oral 26.6g/kg, which can cause dog vomiting and reversal. Betel nut alkali can enhance gastrointestinal peristalsis and produce diarrhea, often gastrointestinal cramps, severe abdominal pain and nausea, vomiting and other symptoms.
The clinical application of the application of anthelmintic drugs has been widely reported, mainly in the following aspects. (1) Treatment of ascariasis:
Among the 524 cases and 4616 cases of ascariasis treated with neem, the average worm excretion rate was 74.31 and 80%, respectively. Neem root bark syrup was used to treat 1348 cases of ascariasis, and it was believed that the deworming rate was high, the use was simple, there were no contraindications, and it could be widely used. So that the potassium junzi acid can significantly expel human roundworms, in large doses of laxatives, also has a high deworming effect, fresh and baked to make the junziren effect similar. Junzi leaves also contain junzi acid potassium, made of leaves, clinically verified more than 1000 cases, also has a roundworm repellent effect, small side effects. The combined application of Junzi and Baibu has a better effect on human pinworms, and it is also effective to treat pinworm disease with Junzi and Baibu alone.
(2) Treatment of taeniasis:
Betel nut has a good effect on pork tapeworm. It has a poor effect on beef tapeworms and must be combined with pumpkin seeds to paralyze the whole insect and easily excrete from the body. The combination of betel nut, pumpkin seeds and pomegranate peel to treat taeniasis can paralyze or kill tapeworm muscles so that they cannot be fixed in the intestinal wall and excreted. Pumpkin seeds combined with betel nut, black ugly or white ugly powder (betel ugly powder) for the treatment of tapeworm disease can achieve better therapeutic results.
(3) Treatment of hookworm disease:
Betel nut decoction for the treatment of duodenal hookworm disease, the effect on hookworm is related to the dose and the number of ambassadors, taking laxatives and stools more often
The effect is good. (4) Treatment of whipworm and ginger flake disease:
Betel nut decoction is used in patients with whipworm disease, who feel that the symptoms disappear and no eggs are found after one month. Betel nut, chili pepper and insecticide are combined to treat ginger tablets and hookworm disease, and the effect is satisfactory.