Methylcobalamin is one of the commonly used drugs in the clinic, often used to treat a variety of nerve damage diseases, but many people have not figured out whether methylcobalamin and vitamin B12 are a drug in the end, and whether it can be taken for a long time.
Methylcobalamin
"Doctor, you prescribed me methylcobalamin, but other hospitals prescribe vitamin B12, why is it different?"
"Doctor, is methylcobalamin safe?" Can you eat it for a long time?"
Methylcobalamin is a commonly used drug for the treatment of peripheral neuropathy, its essence is a derivative of vitamin B12, also known as active vitamin B12, is one of the necessary nutrients in the human body, can promote the metabolism of neurokernal acid, protein, lipids, thereby promoting the synthesis of DNA and RNA. However, many patients in the clinic do not understand the role characteristics and safety of methylcobalamin, so they often ask the above questions, and this article will talk to you about if you take methylcobalamin scientifically.
<h1 class="pgc-h-center-line" data-track="8" > methylcobalamin and vitamin B12 are not a drug</h1>
Vitamin B12
Vitamin B12, also known as cobalamin, is the only vitamin that requires help from intestinal endocrines (intrinsic factors) to absorb it. Its family members mainly include: cyanocobalamin, hydroxycobalamin, adenosine cobalamin and methylcobalamin four brothers, and our often oral vitamin B12 is actually cyanocobalamin, this is because the stability of cyanocobalamin is good, it is not easy to deteriorate and oxidize in the air, and methylcobalamin is active, unstable in nature, and long need to be protected from light.
The essence of cyanocobalamin is the inactive methylcobalamin, which cannot be directly absorbed by the body after taking it, and needs to be converted into methylcobalamin and adenosine cobalamin in the body before it can take effect, so its immediate effect is poor. Secondly, the main indication of cyanocobalamin is the treatment of megaloblastic anemia, which has a poor affinity for neural tissue and is therefore not suitable for the treatment of nerve-damaging diseases. Finally, cyanocobalamin requires liver and kidney metabolism, which has a certain impact on liver and kidney function.
Methylcobalamin is an endogenous coenzyme B12, is vitamin B12 methylation after conversion into activated vitamin B12, also known as methyl vitamin B12, which compared with cyanocobalamin methylcobalamin has good transmission and affinity for neural tissue, easy to enter neuronal organelles, participate in the synthesis of brain cells and spinal cord neurons thymine nucleoside, promote the utilization of folic acid and nucleic acid metabolism, and promote nucleic acid and protein synthesis is stronger, suitable for the treatment of a variety of nerve injurious diseases, such as, trigeminal neuralgia, Stroke, traumatic brain injury, etc. Secondly, methylcobalamin does not need to be metabolized by the liver and kidneys to be absorbed by the human body, which has less impact on liver and kidney function, and the safety is better than that of cyanocobalamin, but the disadvantage is that it is not easy to preserve and needs to be stored away from light.
< h1 class="pgc-h-center-line" data-track="47" > clinical adaptation range of methylcobalamin</h1>
Methylcobalamin can promote the synthesis of lipid lecithin, the main component of the myelin sheath of nerve tissue, accelerate the repair of damaged nerve tissue, improve nerve tissue transmission and metabolic disorders, so it can be clinically used to treat a variety of central and peripheral nerve damage diseases.
(1) Peripheral facial palsy
Peripheral facial palsy is due to a variety of reasons caused by facial nerve damage, clinical manifestations are obviously crooked corners of the mouth, eyebrow raising and eye closure difficulties, liquid outflow from the corners of the mouth when eating, puffing when the cheeks leak, etc., on the basis of conventional treatment, adding methylcobalamin can quickly promote facial nerve recovery and reduce the sequelae of facial paralysis.
(2) Diabetic peripheral neuropathy
Diabetic patients often develop peripheral neuropathy, which is manifested by numbness at the ends of the limbs, like a sock, and in the later stages, stubborn nerve pain, such as ant crawling and knife cutting pain. On the basis of controlling diet, oral hypoglycemic drugs, and strictly controlling blood glucose, methylcobalamin is added to the treatment, which can significantly reduce clinical symptoms such as numbness and pain, and can promote the repair of peripheral nerve tissue and reduce the comorbidities of diabetes.
(3) Neuropathic pain
Trigeminal neuralgia
Trigeminal neuralgia is known as the "world's first pain", which is clinically manifested as stubborn pain in one cheek, accompanied by oral and eye dysfunction. Clinical studies have shown that taking methylcobalamin can effectively reduce trigeminal neuralgia, indicating that trigeminal neuralgia can be alleviated through nerve repair. In addition, a variety of neuropathic pains such as occipital neuralgia, facial neuralgia, radiculocarposa cervical spondylosis can be treated with methylcobalamin, and clinical studies have shown that methylcobalamin can improve the clinical symptoms of patients with a variety of neuropathic pain and improve their quality of life.
(4) Accelerate nerve regeneration after nerve surgery
Postoperative nerve pain
Nerve surgery will inevitably cause damage to the nerves, and the administration of methylcobalamin can significantly accelerate the recovery of nerve function, which may be closely related to its role in accelerating the repair of damaged nerve tissue, improving nerve tissue transmission and metabolic disorders, improving microcirculation and the ischemic hypoxia of nerve cells.
<h1 class="pgc-h-center-line" data-track="52" > precautions for using methylcobalamin</h1>
Although the safety of methylcobalamin is better and does not affect liver and kidney function, this does not mean that you can take methylcobalamin at will, and you must pay attention to the following points when taking drugs.
(1) Pay attention not to take methylcobalamin for a long time
Nerve repair time is often very long, so the need to take methylcobalamin treatment course is also relatively long, but this does not mean that you need to take it all the time, clinically it is generally believed that if you use methylcobalamin continuously for 1-2 months, regardless of whether the symptoms have significantly improved, you should stop taking methylcobalamin. This is because continuous taking methylcobalamin will cause accumulation in the human body, after taking 4 weeks, the concentration of drugs in the blood will reach 2 times that of before taking, which can already achieve the purpose of treatment of most diseases, and continuing to take it is easy to cause drug accumulation, thereby triggering adverse reactions.
(2) Pay attention to drug allergic reactions
Although the incidence is low, methylcobalamin still has the potential to cause allergies, so once allergic reactions such as numbness in hands and feet, rashes, itchy skin, and shortness of breath are found, the drug needs to be stopped immediately and sent to the hospital for treatment.
(3) Pay attention to adverse drug reactions
Clinical results have shown that long-term use of methylcobalamin can cause gastrointestinal reactions such as loss of appetite, nausea, vomiting, diarrhea, etc.; secondly, long-term use can also cause peripheral edema, hypotension syncope and other cardiovascular system damage; a very small number of patients can also have nervous system damage such as tremor of both lower limbs, increased numbness, etc., but most of the adverse drug reactions can be relieved in time by stopping the drug, and if necessary, they can go to a specialist for treatment.
(4) Pay attention to storage away from light
Methylcobalamin is more active, especially sensitive to light stimulation, long-term light will lead to a decrease or loss of methylcobalamin efficacy, so care should be taken to avoid light preservation.
(5) Pay attention to the selection of appropriate drug routes
Methylcobalamin is available in both oral and injectable forms. Oral dosage forms have high safety, but the onset of action is relatively slow, suitable for the treatment of chronic neuropathy; the effect of the injection form is faster, the concentration is larger, and it can be used for acute neurological injury, but the injection dosage form is easy to cause adverse drug reactions, so more attention should be paid to clinically.
<h1 class="pgc-h-center-line" data-track="53" > summary</h1>
Methylcobalamin as a commonly used clinical drug, which has a unique therapeutic effect and precautions, I hope that readers before use to consult a professional doctor, and under the guidance of a professional doctor to take, if there is an adverse reaction, please seek medical treatment in time.
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