<h1 class="pgc-h-arrow-right" data-track="2" > Effect of safflower yellow pigment for injection with different main active ingredients on blood lipid index in patients with coronary heart disease: a meta-analysis based on 11 randomized controlled trials
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LI Hong-zheng 1, 2, TENG Yu-ou 3, YANG Guang 1, ZHAO Xin 1, FU Meng-wei 1, 2, CHEN Heng-wen 1
【 Abstract】
Background Dyslipidemia is one of the main causes of increased risk of cardiovascular disease, and it also has an important impact on disease prognosis. Recent studies have shown that the combination of safflowerin for injection can effectively improve the clinical efficacy of patients with coronary heart disease, but there is no systematic review, nor has it further analyzed the differences in the therapeutic effect of safflower yellow pigment for injection with different main active ingredients.
Objective To evaluate the effect of safflower yellow pigment for injection with different main active ingredients on blood lipid index in patients with coronary heart disease by meta-analysis method, in order to provide evidence-based basis for the clinical application of safflower yellow pigment for injection.
Methods Computer retrieved CNKI, Wanfang Data Knowledge Service Platform, Weipu.com, China Biomedical Literature Database (CBM), Cochrane Library, PubMed, Embase database, and retrieved published randomized controlled trials (RCTs) for the treatment of coronary heart disease with safflower for injection from 2005-02-21 to 2020-04-30. The control group was given conventional treatment, and the trial group patients were combined with safflower yellow pigment for injection on the basis of the control group, and the primary outcome indicators were low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), secondary outcome indicators were triacylglycerol (TG), and safety indicators were the incidence of adverse reactions. Meta-analysis with RevMan 5.3 software. According to the main active ingredients of safflower yellow pigment for injection, it is divided into safflower yellow pigment for injection with safflower total flavonoids as the main active ingredient (safflower total flavonoids subgroup) and safflower yellow pigment for injection with hydroxy safflower yellow pigment A as the main active ingredient ( hydroxy safflower yellow pigment A subgroup), and subgroup analysis and sensitivity analysis are carried out.
Results A total of 11 studies, all of which were Chinese literature, totaled 1 096 patients, including 554 cases in the experimental group and 542 cases in the control group. The results of meta-analysis showed that the patients in the experimental group had a decrease in LDL-C [mean difference (MD) = -0.60,95%CI ( -0.72, -0.49 ) , P < 0.000 01 ] , TC reduction ( MD = -0.79 , 95% CI ( -0.98 , -0.59 ) , P < 0.000 01 ] , TG reduction range [ MD = -0.57 , 95% CI ( -0.73 , -0.41 ) , P < 0.000 01 ] , HDL-C The increase range [MD=0.28, 95% CI ( 0.17, 0.40 ) , P < 0.000 01 ] was greater than that of the control group; the subgroup analysis results showed that the reduction in LDL-C, TC, TC, TG and HDL-C in the total flavonoid subgroup and the hydroxysafflowerin A subgroup were greater than those in the conventional group (P< 0.05). Statistical heterogeneity between the total flavonoid subgroup of HDL-C and the subgroup of hydroxychamnullum a (I2=77.6%, P=0.03) was reported. The incidence of adverse reactions in patients in the experimental and control groups was not statistically significant [Relative risk (RR) = 1.46, 95% CI (0.54, 3.93), P = 0.45].
Conclusions The combination of safflower for injection can effectively reduce LDL-C, TC and TG levels in patients with coronary heart disease, increase HDL-C levels, correct dyslipidemia, and do not increase adverse reactions. And safflower yellow pigment for injection, with hydroxysafflower yellow pigment A as the main active ingredient, may benefit more from increasing HDL-C levels.
【Keywords】 Coronary heart disease; Safflower xanthanin; Lipids; Randomized controlled trial; Meta analysis
【 Medium figure classification number】 R 541.4 【 Document identification code】 A
Source of this article: Li Hongzheng, Teng Yuou, Yang Guang, et al. Effect of safflower yellow pigment for injection with different main active ingredients on blood lipid index in patients with dyslipidemia in coronary heart disease: a meta-analysis based on 11 randomized controlled trials [J] . Journal of Practical Cardiovascular and Cerebrovascular Diseases, 2021, 29( 8): 77-84. DOI： 10.12114/j.issn.1008-5971.2021.00.185.
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