Handheld Raman spectroscopy uses the principle of Raman scattering, which states that when a beam of monochromatic light hits a sample, a small fraction of the light undergoes a frequency change (inelastic scattering) to reflect the molecular structure of the sample. This technique can provide a "fingerprint" spectrum of a substance for both qualitative and quantitative analysis
What are the advantages of handheld Raman spectroscopy?
1. High sensitivity and high resolution: The new generation of handheld Raman spectrometer has ultra-high sensitivity and high optical resolution, which can penetrate transparent sealed packaging for analysis and reduce the risk of contamination and exposure.
2. Fast and accurate: It usually takes less than 30 seconds to complete the material identification, which greatly improves the work efficiency.
3. Portability: small size, light weight, easy to carry and operate, suitable for various on-site environments.
4. Non-destructive: no need to prepare samples, non-destructive testing of raw and auxiliary materials is carried out directly, which ensures the integrity of the sample or evidence chain.
What are the specific application cases of handheld Raman spectroscopy in the pharmaceutical industry?
Raman spectroscopy has been listed as a statutory drug analysis method in the Chinese Pharmacopoeia, United States Pharmacopoeia and European Pharmacopoeia, and is suitable for quality control and component analysis of Chinese medicine pieces. For example, qualitative identification studies based on second-derivative Raman spectra have shown that Raman spectra have abundant "fingerprint" information, which can successfully distinguish different Chinese herbal medicines and their counterfeit products.
Handheld Raman spectrometers are widely used in the identification and validation of raw excipients in the pharmaceutical industry. For example, Bruker's handheld Raman spectrometers can analyze the raw materials in the container and compare them to a database, enabling fast and accurate identification of raw materials.
Handheld Raman spectrometers are also used in the field for the detection of illicit or controlled drugs. For example, during a seizure operation at Hefei Customs, staff used a hand-held Raman spectrometer to detect triazolam, a controlled psychotropic substance, contained in mail sent from Japan to Chuzhou.
Bruker handheld Raman spectrometer Bravo
Bravo is a new generation of trusted, high-performance handheld Raman spectrometers designed for raw material identification analysis, with patented automatic fluorescence subtraction technology and a low-power laser that enables the identification of black, fluorescent, and weakly scattered samples in seconds. Bravo's outstanding performance and design, large touchscreen and intuitive graphical user interface (cGMP certified) provide the most streamlined raw material identification process.
1. Bruker's patented fluorescence elimination technology --- frequency-shift excitation - SSET effectively removes fluorescence interference
2. DuoLASERTM uses 785nm and 852nm dual-wavelength lasers to extend the measurement area of C-H, and this multi-wavelength laser technology can effectively reduce background noise and improve detection sensitivity.
3. Built-in wavenumber correction technology to ensure the long-term stability of wavenumber;
4. Wireless data transmission, can be connected in WiFi environment;
5. Meet the requirements of 21CFRpart11 certification.