新生儿黄疸是新生儿期的常见病。 早产儿出生后一周内黄疸的发生率为80%，足月婴儿则为60%。 当前，黄疸治疗“金标准”是美国儿科学会发布的“ Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation”。
The gold standard for jaundice treatment
However, there are still many problems in the current blue light treatment of jaundice:
1. It is difficult to distinguish physiological jaundice from pathological jaundice;
2. The critical value of TCB is difficult to determine;
3. Over-diagnosis and over-treatment problems;
4. The lack of quantitative parameters limits the development of neonatal jaundice treatment science;
5. The inspection work of medical staff is heavy and there is a risk of accidents;
6. There is a hazard of blue light radiation to medical staff.
The medical intelligent jaundice treatment monitoring system integrates artificial intelligence, photoelectric detection, millimeter wave detection, Internet of Things (IOT), machine vision and other technologies in the treatment of neonatal jaundice. It can output the blue light spectral irradiance of different parts of the newborn's body; irradiance uniformity; transcutaneous bilirubin concentration; Temperature; Breathe; Heart rate; Humidity and other real-time parameters, comprehensive personal information (time, age, weight, skin characteristics), treatment information (wavelength, irradiance, treatment time), physiological parameters (heart rate, blood oxygen saturation, respiration, sleep), etc., through CNN and MLP algorithms to classify the state of neonatal jaundice, to achieve risk warning, treatment effect evaluation and pathological jaundice early warning and other functions.
IoT-based hardware layout
The hospital has hundreds of data node layouts
Special nano anti-blue light film
Miniature blue light radiation monitoring module
The development of quantum dot nano-anti-blue light film effectively uses reflected blue light to protect the visual health of medical staff. The micro blue light irradiance monitoring module can accurately test the blue light radiation value in the range of 380~500nm.
Multi-band transcutaneous bilirubin tester (forehead area)
Skin tone correction
Multi-wavelength relationship with bilirubin concentration
Monitor the summary of various parameters
In the subcutaneous capillary plexus, hemoglobin absorption plays a major role, and traditional transcutaneous bilirubin detection instruments typically use 460 nm and 550 nm light sources to test transcutaneous bilirubin. However, transcutaneous bilirubin testing is affected by vascularity, signs (skin temperature), blood ion concentrations, and differences in the wavelengths of reflection and absorption in the skin. The multi-band transcutaneous bilirubin tester developed by Innova Technology uses Lambert Beer's law and Monte Carlo simulation to find the reference wavelength whose absorbance is independent of the change of bilirubin concentration, and the test results are corrected to improve the test accuracy of transcutaneous bilirubin. A three-layer skin model was applied, with a refractive index of 1.4 for each layer of the skin, a thickness of 70um for the epidermal layer, 130um for the dermis layer, and an infinite subcutaneous tissue, and a skin model was established to improve the transcutaneous biliary data model, based on the comprehensive analysis of children's physiological parameters, blue light irradiance and transcutaneous bilirubin concentration. A neural network is built through CNN algorithms, and MLP algorithms are used to judge treatment effects. The neural network model can effectively judge physiological jaundice or pathological jaundice, and analyze the treatment effect based on the changes of blue light radiation energy and transcutaneous bilirubin, so as to avoid overtreatment of children. Timely detection of children with insignificant treatment effects and relevant early warning behaviors.
Through the effectiveness analysis model, the changes of blue light radiation energy and transcutaneous bilirubin concentration of neonates were predicted, and the correlation curve between blue light radiation energy and transcutaneous bilirubin concentration was obtained, and the treatment effect prediction model was established according to the change curve of blue light radiation energy irradiation time and transcutaneous bilirubin concentration. The model can intuitively and effectively predict the treatment process of children. If the treatment effect deviates significantly from the model's expectations, other hidden diseases in children can be detected in time, and intelligent and precise phototherapy can be realized in a real sense.
DELTA Instruments is a high-tech enterprise specializing in medical device testing equipment, analytical instruments, mold sales and non-standard customized equipment. The main products include: GB9706 series safety and reliability testing equipment, medical needle testing instruments, syringe testing instruments, surgical instrument testing instruments, protective products testing instruments, rehabilitation auxiliary equipment testing instruments, medical signal simulators, medical testing and analysis instruments, ultrasonic testing instruments, radiation testing instruments, various test motifs, customer demand customization services, etc. The products are mainly used in various medical device manufacturing enterprises, scientific research institutes, medical device inspection centers, rehabilitation auxiliary equipment inspection centers, product quality supervision and inspection institutes, medical metrology laboratories, disease control centers, occupational disease prevention and control institutes, entry-exit inspection and quarantine, medical sciences and tertiary hospitals and other fields.