At first I thought it was a cold
Unexpectedly, the disease progressed violently
Presence of multi-organ failure......
It is actually related to "aborted chlamydia".
Repeated fever thought it was a cold
However, multi-organ failure occurs
Recently, Ms. Du (pseudonym), who lives in Panyu District, Guangzhou City, had a fever for 3 consecutive days, with a body temperature of more than 39 degrees Celsius, combined with cough, dizziness, weakness and other symptoms.
At first, Ms. Du thought she had a cold, so she took cold medicine by herself, but her symptoms did not improve, and she still had a recurrent fever, and then went to Panyu Central Hospital affiliated to Guangzhou Medical University for treatment. The results of chest X-ray showed "infection in both lungs", and the outpatient department was admitted to the Department of Infectious Diseases for inpatient treatment of "pneumonia".
On the second day of admission, Ms. Du's condition deteriorated rapidly, sweating profusely, irritability, shortness of breath, and blood oxygen saturation dropped to 80% (more than 95% normal), and she was transferred to the intensive care department for further treatment.
However, Ms. Du's condition continued to deteriorate, and she developed shock, multiple organ failure, and was in critical condition.
The team decided to start VV-ECMO supportive care immediately, and quickly placed the catheter and put it on the machine, and then Ms. Du's systemic oxygen supply was improved and her vital signs tended to be stable.
Rare!
Finally diagnosed with "Chlamydia abortus"
In the short term, high fever appeared, lung CT inflammation was mainly consolidation, and the disease progressed violently, and multi-organ failure occurred......
Which pathogen is the "murderer"? How to find out the "murderer"? Metagenomic next-generation sequencing (mNGS) testing showed that Ms. Du's alveolar lavage fluid and blood mNGS test results showed "Chlamydia abortus".
While the rare results surprise everyone, they provide important clues to the medical team. The medical team immediately adjusted the anti-infection regimen according to the characteristics of Chlamydia abortus and strengthened organ function supportive treatment. After 7 days of treatment, Ms. Du's condition gradually improved, she was successfully weaned off the ventilator, removed the tracheal intubation, and was soon transferred to the general ward for further treatment.
Ms. Du took a group photo with the medical team before she was transferred out of the intensive care department
What is Chlamydia abortus
How can it be prevented?
Chlamydia abortus is a gram-negative intracellular parasitic prokaryotic microorganism whose main hosts are sheep, cattle, pigs, etc., and infected livestock will be aborted in the later stages of pregnancy.
Studies have shown that Chlamydia abortus can be transmitted through the respiratory tract or direct contact to infect humans, causing atypical pneumonia and abortion in pregnant women, etc., which is a zoonotic pathogen. Human-animal infection can occur if humans inhale through the respiratory tract or come into close contact with sick cattle and sheep. But human-to-human transmission is relatively rare. Ms. Du may have been infected when she came into contact with slaughtered cows, sheep and pigs in the kitchen.
According to Huang Jinju, deputy chief physician of the first district of the hospital's intensive care medicine department, aborted chlamydia is usually thought to cause miscarriage, stillbirth and gestational sepsis in human pregnant women, but rarely causes human pneumonia.
He emphasized that for aborted chlamydia infection, the main focus is prevention, and it is necessary to enhance immunity and pay attention to personal hygiene. If there are symptoms such as repeated high fever, chills, chills, dyspnea, etc., and there is a history of contact with poultry and livestock, and no other reasons can be found, they should go to the hospital in time for treatment, and take the initiative to inform the doctor of the relevant contact history, so as to take targeted treatment as soon as possible.
Source: Guangzhou Daily Editor: Hang Qi Editor: Lai Ting Review: Lu Hongmei
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