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Saltan antihypertensive drugs are good medicines for the treatment of hypertension, but Mr. Li, a 50-year-old in Hainan, was diagnosed with hypertensive heart disease after taking irbesartan antihypertensive drugs every day.
In January 2018, Mr. Li's unit organized a physical examination for middle-aged and elderly people, and the examination items were very basic, but many people found more or less problems, and Mr. Li was one of them, which is not difficult to understand.
When measuring blood pressure, it was found that Mr. Li's systolic blood pressure reached 148mmHg and diastolic blood pressure reached 100mmHg, Mr. Li told the doctor that there was nothing abnormal in his body, and that high blood pressure had no effect on him, and the doctor said that the symptoms of hypertension were not obvious, and it may not be that there were no symptoms, but Mr. Li did not pay attention, and Mr. Li's blood pressure also reached the level of secondary hypertension, which needed to be regulated with drugs.
When Mr. Li heard this, he had no choice but to listen to the doctor's advice and go to the hospital to seek help with the corresponding medicine, and then the doctor prescribed irbesartan tablets to Mr. Li. This antihypertensive drug has many advantages, in terms of effect, it has a wider range of action than dipine drugs, and the effect of lowering blood pressure will be better, because it directly acts on the receptors of angiotensin ‖, and can reduce the effect of angiotensin ‖ from all angles.
Then when a person takes irbesartan tablets, it can inhibit vasoconstriction, dredge the water retained by the body, promote the discharge of sodium ions, and also inhibit the secretion of vasopressin, so that people's blood pressure can drop, and in addition to the effect of lowering blood pressure, irbesartan is also very helpful for the treatment of heart disease, can relieve the symptoms of left ventricular hypertrophy, and also has a certain therapeutic effect on atherosclerosis of the arteries.
And the doctor also told Mr. Li that the half-life of this irbesartan tablet is very long, and it can maintain an effective concentration in the blood for 24 hours after taking the drug, and the probability of side effects of irbesartan tablets is very low, and there are few statistics of adverse symptoms caused by irbesartan tablets in clinical practice.
After the doctor's introduction, Mr. Li was not so reluctant to take the drug, and heard that this medicine can also treat heart disease and other diseases, Mr. Li vaguely looked forward to taking this medicine, so after prescribing the drug, Mr. Li went home and began to take it, and he also asked his wife to remind him to take the medicine every day.
It seems that things are developing in a good direction, but there are unforeseen circumstances, after taking the medicine for three months, Mr. Li feels that he will feel palpitations after eating, and when he talks too much, there is a feeling of difficulty breathing and shortness of breath, and after exertion, the symptoms will be more obvious, not only will he be flustered and tight, but also accompanied by wheezing and coughing, and at night, Mr. Li will be even more difficult, and he will have difficulty breathing for a while, which will make Mr. Li wake up frequently.
Mr. Li was very painful, so he went to the hospital for help, and through imaging examination, it was found that Mr. Li's left ventricle of the heart had a significant bulge, which was a manifestation of left ventricular myocardial hypertrophy, and the upper edge of Mr. Li's aortic arch had exceeded the level of the sternoclavicular joint, and there were signs of centripetal protrusion. 98mmHg, so Mr. Li was diagnosed with hypertensive heart disease, and the above symptoms of Mr. Li are typical manifestations of hypertensive heart disease.
Hearing this result, Mr. Li was a little unable to sit still. With a stomach full of questions, Mr. Li found the doctor and asked eagerly, the doctor asked Mr. Li about his medication, Mr. Li said that he had always taken the medicine well, and in order to prevent him from forgetting to take the medicine, he specially called his wife to remind him, and then his wife also expressed her affirmation.
The doctor was silent for a while and then asked, "Did you drink alcohol during the period of taking the medicine?" Mr. Li replied hesitantly: Well, I usually drink a little bit. The doctor said that it may be the cause of alcohol that causes the current hypertensive heart disease. Of course, there is no problem with the doctor's inference, when taking irbesartan, you must not drink alcohol, first of all, alcohol will affect the metabolism and efficacy of the drug, resulting in the antihypertensive effect of the drug is not effective.
At the same time, alcohol will also make the peripheral resistance of the human body vasodilated, resulting in a sharp drop in blood pressure, and at this time, taking antihypertensive drugs, it will cause a sudden decrease in blood pressure, which will lead to insufficient blood supply to the body, causing insufficient oxygen supply to important organs such as the brain and kidneys and being damaged, but the antihypertensive effect of alcohol is not long-lasting, so after the alcohol is metabolized, blood pressure will rebound violently, so this will lead to the aggravation of hypertension symptoms and damage some organs.
So in response to Mr. Li's symptoms, the doctor asked him to have a comprehensive examination, and the routine blood examination found abnormalities, Mr. B's blood creatinine concentration increased, urine protein was also positive, and blood urea nitrogen in the blood was also increased. So the doctor hurriedly treated Mr. Li with kidney protection.
After a period of conditioning, Mr. Li finally regained control of his blood pressure, at this time Mr. Li no longer felt dizzy and headache, Mr. Li hurriedly found the doctor to express his gratitude, the doctor said: Don't be in a hurry to thank me, you have to promise me that you will never drink again, if you drink again, you will not be able to save your kidneys in the future. Mr. Li patted his chest and made a promise!
In addition, the doctor also emphasized that the use of exabitant must be cautious, because if the antihypertensive drug is not taken scientifically, the consequences will be very serious, ignoring these two points, then you take this medicine in vain is a trivial matter, and serious will cause heart disease and even death.
The time of taking the medicine should be fixed, and the dosage of the drug will generally be very clear to the doctor, but the doctor will often say that the time of taking the medicine is more vague, even if it is explained before or after a meal, and some people have a chaotic meal time, resulting in confusion in taking the medicine, which is very unhealthy.
After taking the drug, the drug concentration reaches a stable state, and it often needs to go through 4~5 half-lives, so taking the drug needs to be stable for a long time to get a good harvest. Irregular time of taking the drug will also affect the efficacy of the drug, which may lead to the antihypertensive effect being too violent, causing symptoms of hypotension, and may also make the antihypertensive effect not good, resulting in blood pressure that cannot be controlled for a long time.
And according to the statistics of the highest peak of blood drug concentration, there is also a scientific way to take medicine, if you can make the effective concentration of irbesartan tablets the highest, when the blood pressure is the highest in the day, then taking the drug will have twice the effect with half the effort.
On the other hand, when taking irbesartan tablets, you should pay attention to your blood volume, although it is not easy to pay attention to intuitively, but it can be alerted by some other symptoms of your body, for patients with anemia, it is not suitable to take irbesartan tablets, because the lack of blood volume will lead to electrolyte disorders after taking irbesartan tablets, and the metabolism of blood lipids will not be smooth, and it will lead to abnormal fluctuations in blood pressure, and the lack of blood volume will also easily lead to the concentration of antihypertensive drugs is not in place, and it is easy to make the antihypertensive effect too strong, causing hypotensive symptoms。
Therefore, when you have symptoms of anemia such as paleness, you must avoid taking sartan blood pressure medication to avoid serious danger.
In addition, in the process of taking antihypertensive drugs, you should also pay close attention to your kidney function, mainly look at these three indicators, blood creatinine, blood potassium level, blood urea nitrogen, if there is any abnormality, you need to tell the doctor immediately, and according to the doctor's advice to choose the corresponding protective measures, or under the guidance of the doctor to stop the drug and change the operation.