"A New Era of Precision Skincare"
As more and more sophisticated technologies enter the cosmetics industry, "precision skin care" to meet the needs of a new generation of consumers for deterministic efficacy is becoming a reality.
Yesterday (April 23), the ancient city of Xi'an ushered in a brainstorming focusing on the future of the industry, and the "Regenerative Medicine Precision Skin Care Development Report" conference and academic seminar held by Baihong Group and Qingyan came to an end. At this meeting, based on the strong technology accumulation of more than 20 years of deep cultivation in regenerative medicine, Baihong Group not only comprehensively analyzed the core concept and R&D path of regenerative medicine to empower precision skin care, but also opened a new era of precision skin care as a leader.
So, where does the innovation confidence of Baihong Group come from?
The core of scientific skincare is precision skincare
"When a salamander breaks a leg, it grows an identical leg in two months, and a gecko grows exactly the same when it loses its tail. So, can humans also have the ability to compensate for the physical damage caused by external forces by cultivating new skin, hair, etc. Alternatively, birth defects can be repaired and rebuilt to normal. Now, with the continuous advancement of science and technology, regenerative medicine is turning this reverie into reality.
It is understood that regenerative medicine, as a new interdisciplinary discipline, studies the mechanism of tissue and organ damage, disease and aging, and uses multidisciplinary technologies, methods and products to achieve the purpose of body tissue and organ regeneration and disease treatment, mainly including stem cells, tissue engineering, cell therapy, organ transplantation and other research fields. The development of regenerative medicine has found new and effective biological treatments for the clinical treatment of body tissues and organs.
"Consumers and brands are looking at science-based skincare, but the core of it is the ability to achieve precise skincare. As the first on-site speaker at the symposium, Jin Yan, chief scientist of the "973 Program" of the National Major Scientific Research Program and distinguished professor of the Changjiang Scholars Award Program of the Ministry of Education, said, "The root cause of skin problems comes from cell problems, and the study of cells is the top priority of regenerative medicine. ”
▍Jin Yan, Chief Scientist of the "973 Program" of the National Major Scientific Research Program, and Distinguished Professor of the Changjiang Scholars Award Program of the Ministry of Education
So, what exactly is the relationship between regenerative medicine and precision skincare?
According to Jin Yan, the core of regenerative medicine includes two points, one is to recognize human tissues, organs and diseases, and the other is to solve the problem of disease and regeneration. For this reason, it is necessary to understand everything about human tissues and organs, such as the mechanisms related to development and aging to disease. In this whole process, all problems are based on the cell to know, and the cell is also based on the cell to give the solution.
"The root cause of skin diseases or skin conditions such as dryness, roughness, and pigmentation is a problem with skin cells. Based on the in-depth research of skin cells in regenerative medicine, regenerative medicine-related stem cells, exosomes, tissue engineering and other technical means can be used to provide new possibilities for solving skin problems and achieving precise skin care. He said.
It is understood that as a well-known scholar in the field of regenerative medicine research, Professor Jin Yan and his team have empowered the cosmetics industry with a number of representative scientific research achievements. In 2008, Professor Jin Yan and his team successfully developed and industrialized the first in vitro skin surrogate detection model in mainland China, the 3D recombinant epidermal model Epikutis®. In 2011, the tissue engineering skin results developed by Professor Jin Yan and his team won the first prize of the National Science and Technology Progress Award.
It is not difficult to see that as a cutting-edge technology with a high threshold, regenerative medicine provides a steady stream of scientific and technological power for the realization of precision skin care.
The blockbuster "Report" guides the new trends in the industry
As we all know, skin aging is an inevitable thing. Imagine that when skin aging can be "regenerated" through technical means, this revolutionary result will undoubtedly be sought after by the market. Previously, many internationally renowned beauty companies have regarded regenerative medicine as a key investment direction. On the other hand, in China, after more than 20 years of in-depth exploration, Baihong Group has realized the industrial transformation of regenerative medicine achievements in medical, skin care, food and other fields, laying a solid theoretical and scientific research foundation for the marketization of precision skin care.
At the seminar, Baihong Group also joined hands with Qingyan Intelligence to release the "Regenerative Medicine Precision Skin Care Development Report" (hereinafter referred to as the "Report"). According to Ding Lan, director of blue-eye intelligence, regenerative medicine has been developed for nearly 300 years since Swedish scientists discovered the phenomenon of regeneration in 1740. At the same time, China is developing rapidly in the field of regenerative medicine. As of March 2024, about 180,000 related papers have been published in the field of regenerative medicine and its subdivisions in China, and the number of patent applications is about 100,000.
▍
The release ceremony of the "Regenerative Medicine Precision Skin Care Development Report".
The report points out that regenerative medicine has broad prospects in the field of precision skin care. First of all, regenerative medicine has great potential in the treatment of burns, ulcers, skin aging, etc. Secondly, regenerative medicine can identify the key factors that regulate skin health and have the ability to intervene in the process of studying skin tissue. For example, recurrent sensitivity, barrier insufficiency, aging, etc., can provide effective solutions from theory and practice. In addition, regenerative medicine technology can greatly reduce the steps of human tissue testing and live animal experimentation, which can provide an efficient and accurate experimental method for areas where animal testing is prohibited or not recommended.
Ding Lan said that the reason why the application of regenerative medicine in precision skin care has attracted attention is that the development of precision skin care is facing some problems, such as difficult compatibility, difficult transdermalization, difficult targeting, poor activity, and high threshold. "Domestic precision skin care should be based on the changes in market demand, through multidisciplinary integration and innovation to develop and upgrade the structural modification of raw materials, technical improvement, etc., which is also the latest research direction of regenerative medicine in the field of precision skin care. She said.
▍ Director of Blue Eye Intelligence Ding Lan
So, how to solve the problem of precision skin care?
"Precision skincare is all about precision. Wang Xiangdong, vice president of Baihong Regenerative Future Science and Technology Research Institute, said on the spot that for a core functional raw material, safety and stability are its fundamental principles. However, transporting the functional ingredients to the location where they play a role, and finding the corresponding effective targets and pathways, is the key to solving the problem of precision skin care. After a long period of research and exploration, Baihong Group has successfully built a skin-targeted supramolecular intelligence assembly technology platform (DTSS), which aims to break through the bottleneck of the original cosmetic raw materials.
▍Wang Xiangdong, vice president of Baihong Regenerative Future Technology Research Institute
It is understood that the skin-targeted supramolecular intelligent assembly technology platform (DTSS) mainly solves the problems of relatively low bioavailability, relatively poor biocompatibility, and insufficient understanding of cell surface-specific markers through raw material efficacy improvement technology, raw material transdermal technology and cell targeted recognition technology. Obviously, this not only provides a key idea for achieving precision skincare, but also finds a practical solution.
With the support of five major technology platforms, we have achieved industry leadership
Good seeds are inseparable from good methods, and sowing technology is crucial. According to Wang Xiangdong, around the DTSS technology platform, Baihong Group has also built five platforms: Tai Beam ® Peptide Nano Micellar Technology, Polyglycoside Thai ® Macromolecule Microsphere Intelligent Assembly Technology, Poly Micro ® Biological Vesicles and Exosomes Technology, Adhesion Futai ® Biological Targeted Adhesion Technology, and PolyBeili ® Active Substance Synergy Technology, which modify the functional ingredients through the use of biosynthesis technology and supramolecular technology to improve permeability and enhance targeting and efficiency.
Specifically, the polypeptide ® ® ® nanomicelle technology is based on the self-assembly of amphiphilic peptide molecules to form supramolecular particles, which are equipped with active ingredients to achieve the efficacy of intelligent assembly and intelligent dissociation; The biovesicles and exosomes technology is based on the application research of extracellular vesicles, and the extracellular vesicles are modified and modified to enhance the efficacy through bioengineering technology; the biotargeted adhesion technology of Adhesive Futai ® realizes the targeted storage of active molecules by targeting the recognition of cell membrane integrin receptors; and the synergistic technology of polybeliquin ® active substances is the grafting of active ingredients through chemical modification technology to synthesize new synergistic active ingredients, so as to improve the stimulation and compatibility of functional raw materials.
It is understood that with the technical support of the above five platforms, Baihong Group has developed more than 10 new technology raw materials such as Taishu ® blue copper peptide, viscofutai ® light glycyrrhizin, poly ® micro targeted milk exosome, polyglycoside Thai ® super assembly PDRN, polybeli ® retinol, etc., which have contributed to the industry from the effects of anti-aging, repair, whitening, soothing, hydration and other effects to the industry to achieve precise skin care with regenerative medicine. In addition, Baihong Group has also taken the lead in introducing the common CDMO model in the pharmaceutical field into the cosmetics industry, and relying on this platform to open up the whole link of product planning, raw material customization, product development, product evaluation, registration and filing, intellectual property layout, manufacturing, and scientific communication empowerment, so as to realize the one-stop service of precision skin care.
It is worth mentioning that Baihong Group's brand Ju Yuanya, which was incubated in 2016, is one of the achievements of its technology implementation. At this meeting, Xu Qifeng, general manager of Baiao Regeneration Strategic Brand Center, focused on sharing the Blooming Yaden Sensibility series. According to him, this series has made a breakthrough in solving the application problem of PDRN (polydeoxyribonucleotide) in spreadable skin care by specializing in polyglycotide PDRN superassembly technology. Through the positive and negative charge between molecules, the three-dimensional network structure of supramolecular nanogel is formed, and it can be loaded with other functional ingredients such as peptides and collagen to achieve better soothing repair and anti-aging effects.
▍Xu Qifeng, general manager of Baiao Regeneration Strategic Brand Center
As the so-called wine aroma, I am also afraid of deep alleys. As a cutting-edge technology with a high threshold, it is inseparable from scientific communication while bringing consumers a precise skin care experience. In this regard, an expert from Xiaohongshu's commercial domestic beauty industry platform said, "At present, Xiaohongshu users trust health industry groups with a pharmaceutical background more when choosing beauty products, and such companies should seize this communication to turn it into a brand advantage." ”
▍Xiaohongshu commercialized domestic beauty industry platform expert citation
Fudan University has a Ph.D. in physiology and @成分控创始人鲍峰则提出有三要素, that is, making analogies, visualizations, and frequent feedback. In his view, "science should be in-depth, communication should be simple, and only one knowledge point needs to be disseminated at a time." As long as the recipient has feedback, it confirms that they have mastered this knowledge point. Even if they misunderstand, it means that the purpose of the spread has been achieved. ”
▍Doctor of Physiology, Fudan University, @成分控创始人鲍峰
Overall, the current application of regenerative medicine in the field of precision skin care is still expanding and deepening. However, as Professor Jin Yan said at the scene, "In the integration and development of regenerative medicine with multiple disciplines, a series of technical achievements and technical platforms have been produced, and the joint efforts of the majority of practitioners are also needed to achieve the purpose of precise skin care." For Baihong Group, this is also the responsibility and attitude of the leader of precision skin care.