On April 18, we interpreted 15 articles of literature, focusing on: maternal and infant, malnutrition, postpartum depression, multi-omics, probiotics, dietary fiber, extracellular vesicles, constipation in children, quality, intestinal nerves, colonic diverticulum, MRM Health, food culture testing, Lakai Pharmaceutical, Transocean Medicine, Nestle.
The daily newspaper was published by R. AI-assisted creation generation, manual review and proofreading.
How does maternal malnutrition in childhood affect the growth and development of offspring?
Microbiome——[15.5]
(1) Linear growth retardation due to malnutrition is associated with poor health outcomes, and mothers who experience stunting in childhood are more likely to have stunted children, and this study investigated the effects of the gut microbiota of human malnourished children on the growth and immune function of offspring; (2) The microbiota of healthy or stunted infants were transplanted into germ-free mice, and the offspring inherited the microbiota of the parents, and the offspring were weaned with a malnourished diet to construct a malnutrition model; (3) Compared with the intestinal microbiota of children with healthy growth trajectories, intergenerational colonization of intestinal microbiota in malnourished children can lead to growth retardation, malnutrition, and the development of intestinal disease immune features such as shortening of intestinal villi, decreased liver IGF-1 levels, and accumulation of intraepithelial lymphocytes and plasma cells in the small intestine; (4) Colonization of intestinal microbiota after weaning had less effect on host phenotype;(5) The results support the idea that the influence of microorganisms on the immune system at the weaning stage is essential for later immune function, and suggest that cross-generational gut microbiota colonization is an effective method to study gut microbiota-dependent growth and immune changes in early life.
【Original Information】
Colonization during a key developmental window reveals microbiota-dependent shifts in growth and immunity during undernutrition
2024-04-09, doi: 10.1186/s40168-024-01783-3
Zhejiang University School of Medicine: A new mechanism of intestinal dysbiosis promoting postpartum depression
Brain Behavior and Immunity——[15.1]
(1) Chen Xinzhong's team from the Obstetrics and Gynecology Hospital of Zhejiang University School of Medicine revealed that intestinal microbiota dysbiosis promotes postpartum depression (PPD) through neuroinflammation mediated by hippocampal NLRP3, and explored the potential role of the gut-brain axis in depressive behavior;(2) Using female mice with ovarian resection to construct a hormone withdrawal model to simulate human PPD, it was found that the mice exhibited depressive and anxious behaviors after hormone withdrawal, and the composition of intestinal microbiota changed;(3) In the antibiotic-treated mice, the recipient mice exhibited depressive and anxiety-like behaviors and neuropathological changes in the hippocampus;(4) FMT from healthy mice to PPD mice attenuated depressive and anxious behaviors, reduced NLRP3/caspase-1 signaling-mediated inflammation, increased fecal short-chain fatty acids (SCFAs) levels, and ameliorated intestinal dysbiosis (increasing SCFA-producing bacteria and decreasing Akk bacteria) ;(5) Downregulation of hippocampal NLRP3 alleviated depressive behaviors in PPD mice, while overexpression of NLRP3 in the dentate gyrus of the hippocampus induced depressive-like behaviors in healthy mice, and FMT from healthy mice failed to alleviate depressive behaviors.
【Original Information】
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model
2024-04-08 , doi: 10.1016/j.bbi.2024.04.002
Nature: A multi-omic comparative study of the gut microbiota of infants and their maternal lineage
Nature Communications——[16.6]
(1) This study compared the characteristics of the infants' intestinal microbiota and its maternal lineage through a multi-omics approach, aiming to explore the early development of the intestinal microbiota in infancy;(2) The fecal samples of 200 individuals (including infants aged 0-12 months and their mothers and grandmothers) were analyzed using two independent metabolomics platforms and metagenomics studies;(3) The intestinal microbiota of infants was There were significant differences in function and metabolome from adults, with lower microbiota diversity in infants and differences in multiple metabolite classes (e.g., short-chain and branched-chain fatty acids) that were associated with changes in bacterial populations;
【Original Information】
Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach
2024-04-08-08 , doi: 10.1038/s41467-024-47182-Y
What is the effect of multi-strain probiotics during pregnancy on the development of intestinal flora in babies?
Gut Microbes——[12.2]
(1) a randomized, double-blind, placebo-controlled trial was conducted to investigate the effects of Vivomixx® multi-strain probiotics on the gut microbiome (GM) and perinatal health of 50 obese pregnant women; (2) probiotics did not directly alter the diversity of infant GM or the abundance of specific microbiota, nor were they transmitted vertically from mother to child, but a reduction in obesity-related Corinthia spp. was observed in the probiotic group; (3) (4) At 3 days after birth, infant GM increased in spontaneous infants, increased the relative abundance of Bifidobacterium and Bacteroidetes, and decreased the abundance of Enterococcus spp. in cesarean section infants due to the effect of mode of delivery and antibiotics used during delivery.
【Original Information】
Multi-strain probiotics during pregnancy in women with obesity influence infant gut microbiome development: results from a randomized, double-blind placebo-controlled study
2024-04-09 , Yogurt: 10.1080/19490976.2024.2337968
A high-fiber diet or supplementation with specific probiotics during pregnancy may benefit the gut health of your offspring
Gut Microbes——[12.2]
(1) this study found that supplementation with regulators that promote the production of butyric acid in the gut during pregnancy (a high-fiber diet or specific probiotics) protected offspring from intestinal damage to colitis in adulthood;(2) feeding pregnant female mice a high-fiber diet or supplementation with Lactococcus lactis subsp. lactis or Lactobacillus rhamnosus GG, and then inducing chronic colitis in their offspring as adults;(3) supplementing with a high-fiber diet during pregnancy or supplementation with Lactococcus lactis subsp. lactis reduced intestinal damage in offspring;(4) These results confirm that dietary interventions during pregnancy can affect gut health in offspring, and define diets during pregnancy as a treatment to enhance gut health in offspring.
【Original Information】
A high fiber diet or supplementation with Lactococcus lactis subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring
2024-04-15 , Yogurt: 10.1080/19490976.2024.2337317
Extracellular vesicles in breast milk can be absorbed by the neonatal intestine
Journal of Extracellular Vesicles——[16]
(1) a method for isolating extracellular vesicles (HMEVs) from human milk and neonatal intestinal contents was developed to verify whether HMEVs survive the digestion process of neonates and are taken up by intestinal epithelial cells;(2) HMEVs and extracellular vesicles (dEVs) in digestive juices have a typical extracellular vesicle morphology and are rich in CD81 and CD9 proteins, but do not contain β-casein and whey proteins;(3) HMEV and some dEV fragments contain the mammary-derived protein BTN1A1, and neonatal human intestinal villi rapidly uptake dEVs through clathrin-dependent endocytosis;(4) The results of this study showed that neonatal human intestinal organoids can rapidly absorb dEVs, partly through pinocytosis.
【Original Information】
Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid
2024-04-11, doi: 10.1002/jV2.12422
Lancet: 12% of Asian children suffer from constipation (meta-analysis)
EClinicalMedicine——[15.1]
(1) This systematic review and meta-analysis aimed to assess the prevalence of constipation in Asian children and its related factors;(2) The data of 50 studies with a total of 311,660 Asian children were included, and the overall prevalence of constipation was found to be 12.0%;(3) Age is an important influencing factor for the occurrence of constipation, and the prevalence of constipation in adolescents and children aged 1~9 years is significantly higher than that in infants, but there is no significant difference in the prevalence of constipation in gender and geographical location;(4) Although the included studies used different diagnostic tools or definitions that led to a high degree of heterogeneity in the outcomes, this review added data on constipation in Asian children;(5) This study revealed a high prevalence of constipation in Asian children, providing a basis for developing prevention strategies.
【Original Information】
Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis
2024-04-08 , doi: 10.1016/j.eclinm.2024.102578
Nature: Plasmid distribution and selection pressure in the human gut from a global sample
Nature Communications——[16.6]
(1) Analysis of 11,086 plasmids from 3,467 human gut microbiome samples revealed that the distribution of plasmids in the human gut was mainly affected by random diffusion, but inflammatory diseases significantly altered this process;(2) Only 20-25% of the plasmid DNA was selectively retained in various disease states, which limited their distribution among hosts;(3) Specific plasmid fragments are subject to selective stress due to their unique ecological functions, which are more commonly shared in populations of individuals with similar health conditions (e.g., IBD patients);(4) plasmid fragments contain important genes such as the iron transport mechanism, which is a characteristic gut marker of IBD that influences the severity of inflammation;(5) The results of this study highlight the proliferation and selection mechanisms of plasmids in the human gut as vectors carrying important gene pools that affect the dynamics of bacterial hosts and ecosystems.
【Original Information】
Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases
2024-04-11, Doi: 10.1038/ch41467-024-47272-s
Nature: What is the potential of enteric nerve stem cell transplantation for the treatment of colonic aganglionosis?
Nature Communications——[16.6]
(1) This study evaluated the feasibility and potential of autologous intestinal neural stem cell transplantation for the treatment of colonic aganglion disease in mice;(2) Colonic aganglion model was created in mice by injection of diphtheria toxin, isolated from the small intestine for in vitro expansion and labeling, and transplanted back into ganglion-free colonic segments;(3) Transplanted enteric neural stem cells differentiated into neurons and glial cells in vivo to form new ganglia that can restore colonic contractile activity, which was confirmed by electric field stimulation and optogenetics;(4) This study not only proved the feasibility of autologous intestinal neural stem cells for the treatment of colonic ganglion, but also laid the foundation for the clinical application of this regenerative cell therapy.
【Original Information】
Autologous cell transplantation for treatment of colorectal aganglionosis in mice
2024-03-20, doi: 10.1038/s41467-024-46793-9
Genomic and transcriptome profiling of colonic diverticulum
Good——[24.5]
(1) This study revealed the genetic and cellular determinants of colonic diverticulosis through genomic and transcriptome analysis, providing new insights for understanding the pathogenesis of colonic diverticulosis;(2) DNA and RNA sequencing of colon tissues from 404 patients with (N=172) and without (N=232) colon diverticulosis found that 38 gene expression differences and 17 transcript use changes were associated with colon diverticulosis, indicating that tissue remodeling is the main mechanism of diverticulosis; (3) Diverticulism is mainly related to stromal and epithelial cells in the colon, including endothelial cells, myofibroblasts, fibroblasts, goblet cells, villous cells, intestinal cells, neurons, and glial cells;(4) Mendelian randomization analysis showed that five genes, CCN3, CRISPLD2, ENTPD7, PHGR1, and TNFSF13, may have potential causal effects on colonic diverticulosis, and the expression of ENTPD7 was up-regulated in diverticulum cases;(5) The severity of colonic diverticulosis is positively correlated with a genetic predisposition to have diverticulitis.
【Original Information】
Genetic and transcriptomic landscape of colonic diverticulosis
2024-03-04 , Doi: 10.1136/Gutznol-2023-331267
MRM Announces Positive Phase 2a Clinical Results of Live Bacterium MH002 for the Treatment of Colon Pouchitis
(1) On April 16, MRM Health announced the topline positive results of the Phase 2a clinical trial of live bacterium MH002-PC-201;(2) the MH002-PC-201 study was designed to evaluate the safety and tolerability of MH002 in patients with colon pouchitis;(3) the results of the study showed that there was no problem with safety and a clinical response rate of 46%;(4) MH002 is a formulated live microbial drug composed of 6 strains of intestinal commensal bacteria, which can repair intestinal wall barrier function and re-establish intestinal immune homeostasis;(5) Based on the current positive regulatory feedback, MRM Health plans to initiate a Phase 2/3 clinical trial of MH002 for the treatment of ulcerative colitis.
【Original Information】
MRM Health Reports Safety and Positive Efficacy Data in Pouchitis in Phase 2a Clinical Study with MH002
2024-04-17 , Businesswire
The group standard of "Food Strain Testing, Rhamnosus Lactobacillus Detection, PMA-qPCR Method" was officially released
(1) On April 1, the group standard of "PMA-qPCR Method for the Detection of Lactobacillus rhamnosus for Food Cultures" drafted by the China Food Academy was officially released and implemented;(2) The standard was drafted by the Chinese Society of Food Science and Technology, with the participation of Yili, Mengniu and Tomson Beijian;(3) The establishment of the standard is to accurately identify and quantify the viable bacteria used in food, and ensure the product quality and consistent control of the production process;(4) The PMA-qPCR method can be accurate, stable and Reliable accurate identification and viable count of Lactobacillus rhamnosus.
【Original Information】
The T/CIFST 020-2024 "Food Strain Detection - Rhamnosus Lactobacillus Detection PMA-qPCR Method" group standard drafted by the China Food Academy was officially released
2024-04-16 , China Research Institute of Food and Fermentation Industry
Laekna Therapeutics announced that the clinical trial of LAE102 has been approved by the FDA
(1) On April 15, Laekna Therapeutics announced that it has received IND approval from the FDA for its obesity drug candidate LAE102, (2) LAE102 is a monoclonal antibody against ActRIIA, a novel target involved in the regulation of muscle regeneration and lipid metabolism, (3) LAE102 has been shown to increase muscle loss and fat loss in preclinical studies and can be used in combination with GLP-1 receptor agonists;(4) In the first quarter of 2024, Laekna also submitted an IND application for LAE102 for the treatment of obesity to the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) in China, and (5) Laekna Therapeutics is currently developing other drug candidates, including LAE103 and LAE123, both targeting muscle regeneration and related diseases.
【Original Information】
快讯 | 来凯LAE102肥胖适应症新药临床试验获FDA批准
2024-04-15 , 药智新闻
Transocean Pharma has partnered with Peptidery to enter the GLP-1 market
(1) On April 8, Transocean Pharma and Peptidery signed a product strategic cooperation agreement in China Medical City, Taizhou, Jiangsu Province;(2) The two parties will combine their respective technology and resource advantages to jointly promote the global R&D and commercialization of GLP-1 cooperative products;(3) Peptidery is a company focusing on the innovation, R&D and production of peptide drugs, and is committed to providing high-quality, safe and effective peptide products;(4) Transocean's main business includes the development of Class 2 new drugs for the U.S. and Chinese markets, helping domestic and foreign customers improve the druggability of NCE, and developing sustained-release new drugs and generic drugs for domestic and foreign customers.
【Original Information】
Transocean Pharma signed a strategic cooperation agreement with a U.S. pharmaceutical company to jointly enter GLP-1
2024-04-15 , 越洋医药
Nestlé Qingdao UHT milk project was laid
(1) On April 12, Nestlé Qingdao celebrated its 30th anniversary in Laixi Food Industry Cluster and laid the foundation stone for the UHT milk project;(2) The newly increased and expanded high-temperature sterilized milk project has a total investment of 1.6 billion yuan and is planned to be implemented in three phases;(3) The first phase is expected to be put into operation in June 2025 to increase the production capacity of dairy products;(4) The project will meet the growing domestic consumer demand, further optimize the industrial structure and promote the development of the local dairy industry;(5) Since its establishment in 1994, Nestlé Qingdao has established liquid milk and instant coffee production bases and related R&D centers.
【Original Information】
Nestlé Qingdao 30th Anniversary Celebration and UHT Milk Project Groundbreaking
2024-04-15 , Foodaily
感谢本期日报的审核者:章台柳,RZN,圆圈儿,九卿臣,注册营养师陈彬林,Richard,lxx,Alex Zhang
Click here to read the daily reports for the past 10 days:
0417 | High-score Nature sub-journal: Bringing together the power of global players to help intestinal microbiome research
0416 | Multi-article focus: To protect the gut, no one can do without immune cells and microflora
0415 | Cell Blockbuster Review: Systematic Analysis of Cancer Complexity, the Role of Microbiota Should Not Be Underestimated
0414 | A review of the high-scoring Cell sub-journal, an article about fermented foods
0413 | 3 major articles in the sub-journal to analyze the current situation and future of microbiome therapy
0412 | The 10 articles focus on the new achievements of the domestic team, and the research on intestinal and microbiota has blossomed in many places
0411 | Nature Today: How do colon cells work with T cells to fight off bacterial infections?
0410 | 今日Cell：首个大规模泛癌转移瘤菌群图谱重磅出炉
0409 | 高分Nature子刊：菌群产物药物研发取得新进展
0408 | 3 Million People Data: What Does "Good" Cholesterol Associate with Digestive Tract Cancer Risk?