Lymphocyte subsets refer to the use of flow cytometry to measure the immune function status in the body, the most important of which is to measure the lymphocyte level of TBNK. T lymphocytes are mainly used to kill pathogens, infected cells, Parietal lymphocytes of tumor cells can produce antibodies, which can be combined with antigens, and produce this specific antigen-antibody reaction, such as neutralizing the exotoxin of bacteria, so that it loses its toxic effect, and after the antigen binds to the antibody, it forms a complex, which is also easily eliminated by phagocytes; NK cells are natural killer cells, which can recognize the corresponding ligands expressed on the surface of virus-infected cells, and can kill virus-infected cells. Therefore, lymphocyte subsets are widely carried out in many hospitals and can also be used as a health check-up for normal people.
Lymphocyte subsets are assayed and significant
1. T lymphocyte surface landmarks
The surface markers of T lymphocytes mainly reflect the ability of the body's cells to respond to immunity, can kill pathogen-infected cells and tumor cells, and can express CD4 antigen and CD8 antigen. CD4 antigen has the function of assisting or inducing immune response, and some cells also have killing and inhibition. CD8 antigen can kill target cells and has the function of suppressing immunity.
2. B cell surface landmark
B cells can produce antibodies, which bind to antigens to produce specific antibody antigen reactions that neutralize bacterial exotoxins and make them lose their toxic effects. When the antigen binds to the antibody, it also forms a complex that is easily eliminated by phagocytes. It mainly reflects the ability of the body to respond to humoral immunity.
3. NK cell surface landmark
This is a separate population of lymphocytes that can directly kill certain target cells, including virus-infected cells and mutated tumor cells, without antigen sensitization.
Lymphocyte subset testing is suitable for population
Immunocompromised, deficient or hyperactive patients, especially young children, the elderly and patients with autoimmune diseases;
Patients with chronic diseases: such as type II diabetes, chronic hepatitis, chronic nephritis, cardiovascular and cerebrovascular diseases, etc.;
Cancer patients who are currently in the course of radiotherapy/chemotherapy;
patients with hematologic disorders;
organ transplant patients;
patients with recurrent miscarriage, endometriosis and infertility, etc.;
For patients with fever of unknown cause, investigate the cause;
Sub-healthy people who have no obvious clinical symptoms, but often experience fatigue, forgetfulness, insomnia, constipation or allergies;
Other special conditions, such as the number of lymphocytes is obviously abnormal in the blood routine.