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Recently, the National Adverse Drug Reaction Monitoring Center issued a public announcement that naffen ketoconazole cream is intended to be converted into an over-the-counter drug. In 2022, the sales scale of terminal dermatological chemical drugs in retail pharmacies (urban physical pharmacies + online pharmacies) will exceed 12 billion yuan, a year-on-year increase of 24.73%.
Source: Official website of the National Center for Adverse Drug Reaction Monitoring
Naffen ketoconazole cream is a topical antifungal drug, which is generally used for fungal infections caused by various causes such as tinea manis, tinea pedis, tinea corporis, and tinea versicolor.
The product is a combination of 1% naftifine hydrochloride and 0.25% ketoconazole. Among them, naftifine hydrochloride and ketoconazole inhibit the conversion of squalene into squalene epoxide and the conversion of lanolin steroid to 14-desmethyllanosteroid respectively, thereby inhibiting the synthesis of ergosterol at the same time, and finally exerts antibacterial and bactericidal effects.
According to the data of Minenet, at present, only one company of Chongqing Huabang Pharmaceutical has a production approval for nafinfen ketoconazole cream, and in 2022, the total sales of China's three major terminals and six major markets (see the end of this article for details of the statistical scope) will exceed 130 million yuan, of which the terminal sales of online pharmacies will increase by more than 52%, and the market potential is being released.
Sales trend of naffenketoconazole cream in China's three major terminals and six major markets in recent years (unit: 10,000 yuan)
Source: Minenet Grid Bureau Database
Since the beginning of this year, the NMPA has issued at least 11 announcements on the conversion of prescription drugs to over-the-counter drugs, involving a total of 23 varieties, of which Chinese patent medicines account for more than 70 percent; in terms of OTC classification, Class A drugs (including double spans) are the main force, occupying 19 seats; according to the statistics of treatment categories, the number of drugs for respiratory diseases is leading, with 10 varieties in the list, including Yiling Pharmaceutical's Lianhua Qingcough Tablets, Yangtze River Pharmaceutical's Xinghe cough syrup, Shandong Fupai Pharmaceutical's Chai Huang Oral Liquid and other exclusive Chinese patent medicines.
Since 2023, the NMPA has announced the list of prescription drugs to OTC drugs
Sources: Minenet database, National Adverse Drug Reaction Monitoring Center, etc
Note: The statistical scope of "China's Three Terminals and Six Major Markets" is as follows: urban public hospitals and county-level public hospitals, urban community centers and township health centers, urban physical pharmacies and online pharmacies, excluding private hospitals, private clinics, village clinics, and county and rural pharmacies; The statistics are as of December 26, if there is any omission, please correct.