Didipine vs sartan in antihypertensive drugs, which is better, can you eat the two together?

Many friends asked Huazi, in the antihypertensive drugs, which effect is better between dipine and sartan, is there any problem with eating the two drugs together, and will it cause any impact?

Hanako said that dipine and sartan are commonly used first-line antihypertensive drugs, the two drugs have different antihypertensive mechanisms, each person's sensitivity to drugs is also different, and the antihypertensive effect is not comparable. However, dipine drugs tend to control simple hypertension, while sartan drugs have a better protective effect on the heart and kidneys.

First, the flatten of the dilated arteries

Dipine drugs are calcium channel blockers, which can block the entry of calcium ions into vascular smooth muscle cells, reduce the excitability of muscle cells, make blood vessels relax, and reduce blood pressure. Dipine drugs can also block the entry of calcium ions into cardiomyocytes, reduce myocardial contractility and oxygen consumption, and can be used for the prevention of angina.

The effect of dipine drugs in dilating blood vessels is very obvious, and there are fewer contraindications, suitable for the treatment of various types of hypertension, can be used in pregnant women. However, dipine drugs have a strong effect on arterial dilation, almost no effect on veins, long-term medication, venous return capacity is relatively insufficient, in the lower limbs, especially the ankles are prone to edema adverse reactions.

Second, sartan that can dilate the arterial veins

Sartans are angiotensin-2 receptor antagonists that exert a hypotensive effect by blocking angiotensin 2 from binding to receptors. Angiotensin 2 has adverse effects on the cardiovascular and renal systems, so sartan drugs can play a protective role in the heart and kidneys by blocking the action of angiotensin 2.

Sartans will have a dilating effect on arteries and veins, and will not produce edema of the lower limbs when used. However, when taking drugs, it will cause a decrease in glomerular filtration rate and an increase in creatinine and potassium levels, so patients with renal artery stenosis and hyperkalemia are banned. Sartans are toxic to reproduction and cannot be used in pregnant and lactating women.

Third, the characteristics of the action of horizon and sartan

Dipine drugs exert a faster antihypertensive effect, can block the internal flow of calcium ions, increase the content of nitric oxide in blood vessels, and have a better anti-atherosclerotic effect. For angina pectoris with coronary heart disease, and senile hypertension with simply elevated systolic blood pressure, dipine drugs are more suitable.

Sartans can only cause creatinine elevation in the early stage of medication, and long-term application can improve glomerular filtration membrane permeability, reduce proteinuria, inhibit renal fibrosis, and delay the progression of nephropathy; It can also inhibit ventricular remodeling and reverse left ventricular hypertrophy. It is suitable for the treatment of hypertension complicated by diabetic nephropathy, heart failure, myocardial infarction, left ventricular hypertrophy and so on.

Fourth, the combination of dipine and sartan

More than 70% of high blood pressure requires a combination of two or more drugs to effectively control, and when blood pressure cannot be achieved with one drug alone, it is usually a combination of other antihypertensive drugs on the basis of the original medication, rather than changing to other drugs.

Dipine and sartan are commonly used combinations of drugs. The two act on different antihypertensive targets, and can produce a synergistic antihypertensive effect when combined, and sartan expands the venules, which can increase blood return and improve lower limb edema caused by horizon.

In actual medication, dipine and sartan can be taken at the same time without affecting each other. However, it should be noted that dipine usually takes 10 days to produce the best antihypertensive effect, and sartan usually produces the best antihypertensive effect in 3~6 weeks, so do not rush to adjust the dose of the drug when taking the drug.

To sum up, the effect of dipine on blood pressure control is obvious and the speed is relatively fast; Satan has a better protective effect on the kidneys and heart. In practical application, dipine and sartan are often combined with drugs, which can not only increase the antihypertensive effect, but also reduce the adverse reactions of dipine leading to edema of the lower extremities.

Medications should be used under the guidance of a doctor, if you have any doubts about medication, please consult a doctor or pharmacist. I am Pharmacist Huazi, welcome to follow me and share more health knowledge.