According to the official scramble of major authoritative media on the Internet: on May 10, the new coronavirus treatment drug discovered by mainland scientists was authorized by the national invention patent. The patent specification shows that 10uM (micromoles/L) of quincene inhibits coronavirus replication in multiples of 15393 times.
What does the extremely striking-looking number 15393 represent?
Professor Tong Yigang, the inventor of the patent for the new crown treatment and the dean of the School of Life Science and Technology of Beijing University of Chemical Technology, made the following explanation:
This number is colloquially understood to mean that if there are 15393 viruses without the use of the drug, the number of viruses will be only 1 in the case of 10 micromoles/liter of the thousand goldin drug. In other words, a small amount of quincetin can stop the expansion and spread of the new crown virus.
The patent specification shows that the three effective anti-coronavirus compounds screened out by thousand gold vine, cilameicin and mefloquine hydrochloride were tested, and the 10uM thousand gold vine, syramine and mefloquine hydrochloride could inhibit virus replication by 15393 times, 5053 times and 31 times respectively after 72 hours of cell infection, and the experimental results could be repeated.
A July 2021 article published in the journal Science confirmed this conclusion: Researchers compared the glycogen with 25 other candidate compounds, and the results showed that the EC50 (the concentration that causes the 50% maximum effect, the lower the number, the better) only 0.1uM, which is much lower than other candidates.
The least dose of medication and the greatest difference in effect are the characteristics of the remarkable clinical trial results of senniferin.
What is that golden vine? Is it a extract of plants or Herbs?
Centrum, also known as Centrum; Cepharanthine, English name Cepharanthine, molecular formula C37H38N5O6, this product is a white crystal, is the root of the plant Stephania japonica (Thunb.) Miers of the family Cyprinidae.
How was this plant of the family Hexadeceae discovered? I personally have a subjective understanding that I don't like to spray.
The English name of this golden vine is Cepharanthine, the translation of the name cephalantin, there have been a lot of research on ceflantin and the new crown virus, but many of them are made by the Japanese, and the use of thousand gold vine is very Chinese.
But the extract of the drug source and the pharmacological molecular formula of the late finished product are the transformation of plants to chemistry, which is complicated, so when we say senin, please do not think that just eating the root of the sengosteensis is a medicine, that is unscientific.
Well, under this logic, the scientific name of the golden vine is actually called ceflandine after the finished product!
Here's a graph of how each antiviral drug has been on different variants of the new coronavirus:
Ec50 on the far left of the picture can be more commonly understood as a label of an experimental dose of in vitro experiments in pharmacology, EC50 is half of the maximum effect concentration refers to the concentration that can cause 50% of the maximum effect. Foreign EC50 is generally within 10 M, and the Remdesivir effect that Pfizer has listed is the best, and the effective EC50 concentration for various variants is about 0.1 M.
The EC50 of the new crown virus is only 10uM, which is far lower than other candidates, which seems to make some sense, because from the above figure, it is not far lower than other candidates.
There is also interesting news from Japan, since the birth of Senjin vine, Senjin vine (ceflandine) in Japan has been approved as a drug to prevent hair loss! But no patent was filed.
This time, domestic scientists will be sengonin (ceflandine) to become a patent for the treatment of new coronavirus drugs, do not know how Japan will feel, has been studying senchinito in Japan has not found its 'special effect'.
I also found a rough timeline:
Before 2020, the plantarinae has been discontinued for many years.
In March 2020, the English edition of the Chinese Medical Journal published the research results of Professor Tong Yigang's team in the School of Life Science and Technology of Beijing University of Chemical Technology online. Using an alternative model of the new crown virus, the team found that the golden vine has a therapeutic effect on the new crown virus.
In February 2021, the invention patent was officially applied.
In May 2022, the patent was granted.
In the second half of 2022, Canadian pharmaceutical company PharmaDrug will conduct clinical trials of oral enteric-coated preparations of circadianin for the treatment of NEW CROWN pneumonia under FDA supervision.
This seems to be a bit like the history of SARS, if applied to the new crown virus, it means that the ability of 84 disinfectant to inhibit the replication of the new crown virus is 100%, but can we really drink 84 disinfectant? Obviously not.
Therefore, I think everyone should rationally look at the occurrence of this "new crown drug" patent, because it is still only the research stage, and animal experiments and clinical phases I, II and III experiments have not been carried out, and whether it can treat the new crown in the end, I think it is still impossible to draw conclusions!
In short, cheering for Chinese scientists, I hope to develop a special drug to kill the new crown as soon as possible and restore normal life to mankind as soon as possible.