Recently, a real-world research paper published by the international journal Avenue-based Complementary and Alternative Medicine, "Research on the Effectiveness and Safety of Lianhua Qingpeng Capsules in preventing COVID-19: Prospective Open-Label Controlled Trials", has attracted attention, demonstrating for the first time the effectiveness and safety of Lianhua Qingxiao Capsules in the prevention of close contacts and sub-close contacts of NEW Crown Pneumonia. The preventive application of Lianhua Qing plague in close contact groups can reduce the rate of positive infection of new crown pneumonia by 76%.
In fact, for more than 2,000 years, Traditional Chinese medicine has accumulated valuable experience and prescription medicines in epidemic prevention and control. Ancient mainland physicians have recognized that epidemic disease is a disease with strong contagiousness, also known as "plague", "plague", etc., such as the Spring and Autumn Warring States Period "Yellow Emperor's Inner Classic" recorded: "The five plagues are easy to infect, regardless of size, similar symptoms", clearly pointing out that the epidemic has a strong contagiousness and similar symptoms after infection. According to the "Chinese Epidemic History", there were more than 300 major epidemics in the mainland from the Western Han Dynasty to the end of the Qing Dynasty, about once every 6 years, which is consistent with the frequency of outbreaks of respiratory infectious diseases in the past 20 years, indicating that the mainland was a country with a high incidence of epidemics in history, but the population of the mainland from the Western Han Dynasty to the end of the Qing Dynasty showed an upward trend, and the population of the late Qing Dynasty reached 400 million. In contrast, the plague in Europe in the 14th century killed about 25 million people in 1/4 of the population, and the Spanish flu in 1918 caused nearly 100 million deaths. It can be seen that the important role of traditional Chinese medicine in the prevention and control of epidemic diseases and the protection of national reproduction and prosperity cannot be ignored.
The preventive medicine formed in the process of fighting epidemics in traditional Chinese medicine in the past two thousand years is its valuable clinical experience, and the concept of "prevention" was first seen in "Zhou Yi": "Gentlemen think of trouble and hesitate to prevent it", that is, to think of danger in times of peace and prevent problems before they occur. The "Yellow Emperor's Inner Classic" extends the concept of prevention to the field of medicine, and puts forward the idea of "treating the disease before it is", that is, preventing the disease before it occurs, preventing the change of the disease before it is healed, and preventing it after the cure, and ancient Chinese medicine combines the idea of treating the disease in the process of fighting the epidemic, and summarizes the "first evidence of the use of drugs, truncation of the disease situation" for epidemic prevention and control. In his monograph on the treatment of plague, "On the Plague", wu Youke, a physician of the Ming Dynasty, pointed out the valuable experience of "expelling evil spirits as the first meaning" and "expelling evil spirits as the first priority" and "expelling evil spirits as early as possible" based on the characteristics of the evil of epidemics and the rapid transmission of diseases. The use of compound Traditional Chinese medicine for epidemic prevention and control reflects the unique advantages of prevention and treatment, prevention and control.
Early intervention in epidemic disease is advocated for pre-evidence medication and truncation of the disease situation, in addition to active intervention after the onset of the disease, it also includes intervention and prevention at the stage of pre-disease. The Spring and Autumn Warring States "Yellow Emperor's Inner Classic" records: "Xiao Jindan... Take ten capsules, no disease dry also", pointing out that by taking drugs can prevent the epidemic. Zhang Zhongjing of the Eastern Han Dynasty proposed "On Typhoid Fever" to "take medicine first" for the prevention and treatment of infectious diseases. During the Eastern Jin Dynasty, the "Elbow Reserve Emergency Formula" recorded various preventive prescriptions, which were prevented by taking them internally, inhaling, applying externally, wearing them, burning and smoking, and hanging. Sui Dynasty Chao Yuanfang's "Theory of the Origin of Diseases" Yun: "The disease qi is easily infected, and even extinguished, extending to outsiders, so it is necessary to take medicine in advance to prevent it." In the Ming Dynasty Li Shizhen's "Compendium of Materia Medica", it is recorded that medicinal sachets were worn to prevent poisons. Ye Tianshi of the Qing Dynasty pointed out that "before being ill ... That is, drinking aromatic righteous qi belongs, do not let evil enter the first righteousness", Qing Dynasty Yu Jiayan also said: "Before the illness to drink aromatic positive qi medicine, then evil can not enter." Modern physician Zhang Xichun created the "Health and Epidemic Prevention Baodan" in the "Records of Medical Heart", which is usually taken orally to achieve the purpose of preventing infectious diseases.
In the practice of fighting the epidemic for two thousand years, a system of preventive measures and distribution of preventive drugs has been established by the government in a unified organization, such as the Western Han Dynasty's "people with epidemic diseases, empty houses, for the purchase of medicine", which is also the earliest record of the government setting up epidemic isolation points and distributing intervention drugs. In the Southern Song Dynasty, when there was an epidemic epidemic, the Taiyi Bureau drew up a prescription and distributed it to the army as a standing epidemic prevention drug; the Ming Dynasty government sent medical officers to inspect the epidemic situation and distribute drugs; during the Qing Shunzhi period, the Tai Hospital distributed drugs for the people to prevent and control the plague; during the Kangxi period, "the epidemic was prevalent, and the medicine bait was widely applied"; and during the Qianlong period, "the epidemic was valued, and the bureau was set up to administer medicine". It can be seen that in the process of fighting the epidemic, traditional Chinese medicine has formed valuable experience in preventing medication and controlling the epidemic, and has established a system for the government to organize and manage the distribution of preventive drugs. Whenever the epidemic breaks out, generations of famous doctors have prescribed pharmaceuticals to prevent and control the epidemic, and philanthropists have funded the purchase of drugs to do a lot of good deeds to prevent and control the epidemic, which is similar to the current government procurement, prescriptions of famous doctors and charitable donations in the fight against the new crown epidemic, which is the embodiment of the traditional experience and noble medical ethics of traditional Chinese medicine.
Traditional Chinese medicine Lianhua Qing plague gathers the three famous recipes of traditional Chinese medicine to fight against epidemic diseases for two thousand years, based on the Eastern Han Dynasty Zhang Zhongjing's "Treatise on Typhoid Fever and Miscellaneous Diseases" Ma Xing Shi Gan Tang and the Qing Dynasty Wu Jutong's "Wen Disease Article Discernment" Silver Warp Scattering as the basic formula, drawing on the Ming Dynasty Wu Youke's "Wen Epidemic Theory" to treat epidemic diseases with rhubarb's experience of "first evidence of medication, truncation of the disease situation", with wu Huoxiang aromatic wet protection of the spleen and stomach, Rhodiola Rosea to improve immunity and integrity. The whole party takes into account both evil and righteousness.
During the first flow in 2009, evidence-based medical studies controlled by clinical randomized double-blind multicenters and Tamiflu confirmed that Lianhua Qingpeng was comparable to Tamiflu in terms of viral nucleic acid negative time, and the antipyretic time and relief of influenza-like symptoms such as cough, sore throat and fatigue were better than Tamiflu, and the treatment cost was only equivalent to 1/8 of Tamiflu, showing the advantages of comprehensive intervention. At the same time, the Hebei Provincial Health Department quickly controlled the epidemic situation with the use of Lianhua Qing plague prevention drugs for 20,553 people in the Langfang Jialiu epidemic area, and the data results showed that the symptom incidence rate of the Lianhua Qing plague prevention group was 1.2%, which was significantly lower than that of the people who took other drugs for prevention (symptom incidence rate of 6.8%) and unmediated (symptom incidence rate of 8.8%).
In the early days of the outbreak of new crown pneumonia in Wuhan in 2020, Lianhua Qingyi was included in the "Fang Cabin Hospital Work Manual", which was widely used in more than 1,600 hospitals in Hubei Province, including Wuhan Fang Cabin Hospital, and was widely used in designated hospitals, isolated people, and close patients. A randomized controlled multi-center clinical study involving 23 hospitals confirmed that the clinical symptom disappearance rate of patients with confirmed new crown pneumonia in the Lianhua Qingpeng group reached 91.5%, the performance of lung inflammation improved, and the clinical cure rate was increased by 19% and the conversion rate was reduced by 50% compared with the control group of conventional treatment of Western medicine.
In 2021, a prospective, open-label, controlled trial of 1976 cases of close contacts of COVID-19 was completed, and the results showed that the positive rate of nucleic acid test after the prevention of Lianhuaqingpest in closely contacted populations was 76% lower than that of the control group, and the results were published in Apartment-Based Basic and ElectronicMedicine. The clinical trial is a real-world study on the prevention effect of Lianhua Qing plague for people in the new crown pneumonia isolation point, reflecting the real situation in the prevention and control of the epidemic. At present, the new crown virus is constantly mutating, and the currently circulating Omilkerong mutant strain shows the characteristics of strong contagiousness, fast transmission speed, and complex and hidden transmission, which undoubtedly greatly increases the difficulty of epidemic prevention and control. The results of this clinical study have important reference significance for the current reduction of positive nucleic acid detection rate for the current preventive drugs for close populations at isolation points.
Since its listing, Lianhua Qingyi has been included in the diagnosis and treatment plan issued by the National Health Commission and the State Administration of Traditional Chinese Medicine for 30 times, and has been included in the recommended drugs, mild and ordinary recommended drugs in the medical observation period of the "Diagnosis and Treatment Plan for Pneumonia Infected by Novel Coronavirus Infection (Fourth to Ninth Edition)" issued by the National Health Commission. The medical observation period includes close contacts of confirmed, suspected and asymptomatic infected people. In March 2022, the Hebei Provincial Administration of Traditional Chinese Medicine issued the "Hebei Provincial Novel Coronavirus Pneumonia Traditional Chinese Medicine Prevention and Control Plan (Trial Sixth Edition)", and Lianhua Qing plague was used for population prevention and recommended drugs.
Experimental studies have also confirmed that Lianhua Qingfeng can effectively inhibit SARS virus, H1N1, H3N2 influenza virus, and new crown pneumonia virus (wild type, Delta, Omicron virus strain), and at the same time effectively antibacterial, antipyretic, cough and phlegm, regulate immune function, and play an important role in the prevention and control of influenza A and new crown pneumonia in the mainland. This kind of integration and regulation advantage of both dispelling evil and suppressing viruses and supporting the regulation of immune function has become the pharmacodynamic basis for both prevention and treatment of Lianhua Qing plague.
With the sudden outbreak of the epidemic in Hong Kong, under the care of the central and national governments, the Ministry of Industry and Information Technology allocated and the Hong Kong SAR government urgently procured Lianhua Qingpi, and distributed epidemic prevention health kits, including Lianhua Qingpi, to 3.5 million families in Hong Kong for prevention and treatment. Data from China Commentary Telecom: Chinese medicine must be corrected to save Hong Kong. The data analysis believes that the public's sarcastic sentiment index is high in the early stage, to the positive sentiment index after the government distributed Lianhua Qing plague significantly increased, and its comments pointed out that in the early days of the fifth wave of the epidemic in Hong Kong, the efficacy of the Chinese medicine Lianhua Qing plague capsules produced in the mainland was controversial on social media, and even "smeared" by people with ulterior motives, which made the outside world misunderstand that taking the drug would lead to liver failure and other serious diseases, which reduced the confidence of Hong Kong citizens in the fight against the epidemic in Chinese medicine. However, with the outbreak of the epidemic tsunami that makes public hospitals "burst the pot", a large number of confirmed patients are left at home to self-medicate, there is no other Western medicine available, only Chinese medicine, more and more patients in the self-medication and obtained a better effect, the negative mood of public opinion on Lianhua Qing plague capsules has been greatly reduced. The inclusion of Lianhua Qing plague capsules in the anti-epidemic articles of the central government to hong Kong has continuously increased the positive sentiment index of Hong Kong citizens against the epidemic of traditional Chinese medicine, and Lianhua Qing plague has won the affirmation and welcome of Hong Kong citizens with its precise prevention and treatment effect. See figure below:
http://bj.crntt.com/doc/1063/4/1/2/106341229_3.html?coluid=7&kindid=0&docid=106341229&mdate=0411095639
Lianhua Qing plague has good safety, as a proprietary Chinese medicine that has been on the market for nearly 20 years, according to the data of the national adverse drug reaction monitoring system, the cumulative adverse reaction reporting rate is one in 100,000, which is a very rare level. A short course of preventive medication of 3-5 days can also reduce the occurrence of adverse reactions.
Due to the strong contagiousness of the Omilon virus, the characteristics of transmission concealment, many asymptomatic infected people who are in the incubation period or have not been found in time may cause unconscious transmission, there have been repeated reports of transmission of the virus through mail couriers, cold chain food, fruits, clothing and other contact routes, requiring multiple nucleic acid tests to screen out positive infected people, and some patients can not be diagnosed and isolated in time in the early stage of virus infection, with the development of the epidemic there is a new term "time and space companion", 14 days and confirmed people whether physically passing by, Or the drift in communication signals, all are identified as "space-time accompaniment", which further expands the scope of close contacts. The study of Lianhua Qing plague capsules to prevent new crown pneumonia reduces the positive rate of close contact populations by 76% the study enlightens us that families often prepare Lianhua Qing plague, and when the possibility of time and space companion occurs, timely short courses of medication are beneficial to reduce the incidence of the disease and prevent the spread of the epidemic. In this sense, government procurement and distribution of medicines, corporate group purchases and distribution of medicines, charitable donations and distribution of medicines, so that families can always prepare flowers and plagues are undoubtedly the care of the government, society and philanthropists for the health of the people.