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Huazhong Agricultural Team
Find the gene that controls the fish spines,
It is expected to achieve the news that eating fish without picking thorns,
Caused widespread concern.
It is understood that
The team of Professor Gao Zexia of the Fisheries College of Central China Agricultural University
and the team of academician Gui Jianfang of the Institute of Aquatic Sciences of the Chinese Academy of Sciences
Already in bream,
Grass carp and silver crucian carp were tested
Knock out the main effect genes that regulate the growth of fish bones,
Obtained of the first generation of heterozygous (F0 generation).
Lesser spiny fish grow well and have a normal morphology,
There is no difference between habits and common spiny fish.
As soon as this message comes out,
The FOODIE DNA of many netizens moved
Some netizens put forward more bold ideas
↓↓↓
For questions that will not affect the swimming of fish,
@Huazhong Agricultural University Fisheries College said,
"Don't worry!"
Behind the "foodie welfare",
It's researchers day in and day out
Trial and error and research.
December 18,
Professor Takazawa Xia recounted
The ins and outs of the topic of "spineless fish" as the key topic ↓
Pick and burn for three months
The first domestic patent in the study of fish bones
The scientific name of the fish spine is intermuscular bone,
It is ossified from the tendons in the tendons.
From the point of view of the source of formation,
Fish with long spines actually
Just like the human bone spur.
Fish bones in addition to the trouble when eating,
It is also an obstacle to large-scale mechanized processing.
In 2012,
Kasumi Takazawa, who graduated with a ph.D
The subject of making bream spiny and spineless was chosen.
The key to "creating" a spineless fish is
Find controls to the growth of fish bones
The gene that plays a major role (the main effector gene).
This is a whole new field.
They will take every fine thorn
Carefully picked out from the bream,
Remove connective tissue,
Before degradation,
Quickly put in liquid nitrogen for preservation,
And then quickly extract the RNA,
Rapid gene expression.
Although it is fast,
But pluck the fish's spines out of the fish one by one,
And then the gene is expressed,
The whole team took three months
Only then did high-quality fish spine RNA come up.
They eventually sifted out nearly 50 candidate genes.
It is precisely because of this "provocative" procedure
Very professional and accurate,
Improved methods for extracting RNA,
Also realized in the world
The first comprehensive expression of the fish spine gene,
Gao Zexia applied for this
The first domestic patent in the study of fish bones.
7 years of searching
The fish bones have changed, and the fish meat has not changed
Professor Takazawa's team
Put nearly 50 genes found into it
Standard mode fish zebrafish body to do verification,
Using gene editing technology,
Knock out these genes one by one, one by one,
See if and how the growth of the bones changes.
The verification process lasted 7 years.
One day at the end of 2019,
"Suddenly",
The main effect gene appeared,
This time it was really a spineless zebrafish.
The spineless phenotype of hundreds of fish is very stable,
After several generations of breeding,
The offspring zebrafish are also spineless.
It can be determined that the main effect gene can be found.
This is an all-thorny fish
are common genes.
After measurement,
Although the fish bones have changed,
The content of amino acids and fatty acids in fish meat
There is no significant difference from the common spiny fish,
The meat quality remains unchanged.
presently
Lesser-spiny fish grow well and have a normal morphology.
Wuhan's bream matures every two years,
Crucian carp ripens every year,
Then these mature hybrids are less stinging fish
Purified and bred generation,
By the third generation (F2 generation) you can
Obtain homozygous genetic traits stable
Truly spineless fish.
The spineless fish is coming,
Are you looking forward to it?
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Source: China Youth Daily, Yangtze River Daily, People's Daily
Editor-in-charge: Zhang Yongqun
Editor: Wu Yaqi, Sun Xiaoting, Wang Yuanfang