1. Launch soon! The human organoids, first sent to the International Space Station, will bring something to the treatment of brain diseases
Source: Academic Latitude and Longitude
Microglia produced by differentiation from iPSCs
The National Stem Cell Foundation (NSCF) recently announced that a team of researchers from the biotechnology company Aspen Neuroscience and the New York Stem Cell Foundation (NYSCF) Institute will perform an unprecedented mission: They are about to launch the first special 3D cell models to the International Space Station , neural organoids , which are formed from induced pluripotent stem cells (iPSCs) derived from patients, which are expected to provide new perspectives on solving incurable neurodegenerative diseases.
The mission is scheduled to launch from the Kennedy Space Center in Florida on the morning of December 4, EST. The main goal of this space mission is to study Parkinson's disease (PD) and multiple sclerosis (MS).
Read the link: Launch coming soon! The human organoids, first sent to the International Space Station, will bring something to the treatment of brain diseases
2, chip neurons | Nature-Communication
Source: Nature Nature Research
Neuronal chip | Source: University of Bath
A paper published this week in Nature Communications, The Optimal solid state neurons reports a method for making silicon chips that reproduce the electrical behavior of biological neurons. Using this method, it is expected to develop biomimetic chips to repair biological circuits in the nervous system that function abnormally due to disease.
Alain Nogaret and colleagues at the University of Bath in the United Kingdom designed a microcircuit that mimics ion channels and integrates and responds to primitive neural stimuli like biological neurons. Afterwards, the authors reproduced the activity of individual hippocampal neurons and respiratory neurons in a silicon chip. Through 60 electrical stimulation protocols, the authors found that solid-state neurons produced almost exactly the same electrical response as biological neurons.
Read the link: Neurons on a Chip | Nature Communications
3, Gut: The role of brain imaging technology in brain-intestinal interaction diseases
Source: Siying Technology
Great progress has been made in the development of new imaging techniques to study the structure, function, and metabolic properties of brain regions and networks. However, the identification of preclinical susceptibility factors and prognostic predictors has been slow. Therefore, researchers from the Neuroimaging Research Group at UCLA have made a new discussion on the role of brain imaging techniques in the study of brain-intestinal interactions in functional intestinal disorders. This article was published in the prestigious journal Gut. In this article, the author is from
Understand changes in brain structure and function and their role in the pathophysiology of DBGIs (brain-gut interaction disorders).
Understand changes in brain structure and function and their role in the pathophysiology of DBGIs
At present, the main multimodal research methods and techniques are used
The pathophysiology of DBGIs is better understood from PET ligand studies as well as the exploration of brain metabolism by MR spectroscopy
Analysis of multimodal brain imaging data
A big data approach to study brain-gut interactions
Neurobiological basis for determining therapeutic efficacy using neuroimaging and its relevance to DBGI pathophysiology and treatment
How do pharmacotherapeutic interventions affect brain network changes in DBGIs?
How do non-pharmacological interventions affect changes in brain networks?
These ten aspects provide a detailed and appropriate analysis of the main research scope, main research objects, main research views, main research methods, characteristics of different means, how multimodal methods converge, the impact of drug therapy and non-drug treatment, and the role of brain networks in the whole research.
Read: Gut: The Role of Brain Imaging Techniques in Brain-Gut Interaction Disorders
4, creativity and bipolar disorder: anything is possible
Source: Spirit Time
To study the relationship between emotional state and creativity at different times in people with bipolar disorder, Professor Natalie Miller from Australia and his team conducted a 1-year study. The results were published in the May 2019 issue of the journal Psychiatry Research.
Studies have shown that self-reported creativity varies significantly between different stages of bipolar disorder (depression, hypomania, mixed states, and periods of remission). Patients in hypomania and remission are more creative than depressed patients, especially in theater, math or science, and human interaction.
Read the link: Creativity and Bipolar Disorder: Anything is possible
5, long text detailed explanation: electroconvulsive therapy
Source: Medical Pulse Psychiatry
Electroconvulsive therapy is one of the most effective treatments in psychiatry, but it is clearly underapplicated at present, in large part due to the poor "reputation" and the lack of understanding of modern electroconvulsive techniques. For these reasons, many patients miss out on this potentially fate-changing treatment.
An article was published online on November 27 in Acta Psychiatr Scand. In the review, the US researchers combined the new evidence to discuss the clinical indications for electroconvulsiveness, patient selection, current operating norms, etc., aiming to improve people's understanding of electroconvulsive therapy and its status.
Read the link:
Long article details: Electroconvulsive therapy | Clinical essentials
6, PLoS Biol: Poverty also affects the gut microbiome?
Source: Cells
Poverty limits people's access to healthy food, healthy environments, and the likelihood of living a "stress-free" life, thereby increasing their risk of multiple diseases. In addition, Suzanne Ishaq of the University of Oregon and colleagues in a new article published Nov. 26 in the open access journal PLOS Biology argue that poverty can also harm health by lowering the homeostasis balance of beneficial microbes.
Scientists have linked low microbial diversity to poor health conditions, including obesity and associated metabolic problems, as well as a variety of mental health and psychiatric disorders. These problems can disproportionately affect the poor and exacerbate existing health disparities.
PLoS Biol: Does poverty also affect gut microbes?
7, parents are poor, children's brains and genes will suffer, Nature confirmed...
Source: Medical Neurology Channel
A study published in Nature used economic income as a benchmark to measure the neurophysiological effects of "poverty." A group of researchers from Columbia University scanned the brains of 1,099 children, and after correcting for genetic disparities in age, sex, and ethnicity, they analyzed and found that children with an annual household income of less than $25,000 were directly 6% less cerebral cortex than children with an annual household income of $150,000.
They further found that for the lowest-income families, an income gap of a few thousand dollars is enough to cause major changes in the neural structure of children's brains, especially in the brain regions that control language and judgment and decision-making functions! And, their tests showed that children's cognitive functions, such as literacy and memory, declined as household income declined.
Read the link: Parents are poor, children's brains and genes suffer, Nature confirms...
8. Some foods can cause depression? Scientists give you the answer
Source: Alzheimer and Brain Health
Although it has been thought that the two may be linked by the effects of mental illness, a growing body of research suggests that this connection may actually be supported by biological mechanisms. A new study led by scientists at the University of Glasgow in Scotland shows a direct causal relationship between a high-fat diet and the onset of depression.
The new study suggests that food fats can enter the brain, disrupt specific signaling pathways in the hypothalamus, and subsequently induce depressive symptoms. The new study was published in the journal Translational Psychiatry.
Read the link: What Foods Cause Depression? Scientists give you the answer
1, Brain Science Daily | study found that autism, ADHD and mothers use this during pregnancy
2, Brain Science Daily | how does the brain perceive the value of objects? The biological theory behind economic behavior