Sanxiang Metropolis Daily, New Hunan Client November 15 (All-media reporter Li Qi correspondent Zhu Wenqing) The season to eat grapefruit has arrived, sweet and sour grapefruit, do you love to eat? But grapefruit can interact with a variety of drugs!
A few days ago rushed to Weibo hot search of a news report: Jiangsu Changzhou 60-year-old Ms. Wang, usually need to take drugs to control blood pressure, recently after eating grapefruit actually caused hypotensive shock, almost died, after rescue before finally turning the crisis into safety. Is grapefruit really so scary? Wen Dandan, a pharmacist in charge of the Pharmacy Department of Changsha Central Hospital, analyzed it.
According to Vindhan, grapefruit, also known as grapefruit, is one of the most popular fruits in everyone's daily life. Grapefruit juice is often widely used in production and life as a beverage or flavoring agent. However, grapefruit is also a fruit that pharmacists focus on.
Important components in grapefruit juice, such as flavonoid naringin, and furfurancoumarin 6', 7'-dihydroxybergamotine, etc., inhibit the CYP3A4-mediated first-pass effect in the intestine, so that the blood concentration of some drugs increases, resulting in adverse consequences such as inconsistent efficacy and expected efficacy, increased adverse reactions and so on.
There are many oral drugs affected by grapefruit juice, and most of the drugs that interact with grapefruit juice are substrates of the enzyme CYP3A 4, such as the commonly used calcium channel blocker verapamil, the hypolipididic drug simvastatin, the antihistamine drug terfenadine, the gastrointestinal motility drug cisabili, the sedative hypnotic diazepam, the antipsychotic drug clomipamin, the antiparasitic drug artemisinin and the like. There are individual differences in the expression of CYP3A4 on the mucosa of the small intestine, so there are also large individual differences in the interaction of grapefruit juice with the drug. Some people take a glass of grapefruit juice of about 200mL, which can lead to an increase in peak blood concentrations, potency enhancement, or increased adverse effects; for others, a similar effect is not observed.
Frozen concentrated, diluted or freshly frozen grapefruit juice can interact with drugs, but the degree of interaction varies from type or brand of grapefruit juice to different types or brands, depending on the amount of active ingredients in the grapefruit juice. The effects of grapefruit juice can be maintained for 24 h, even if taking a glass of grapefruit juice a few hours before taking the drug will increase the oral bioavailability, efficacy, or incidence of adverse drug reactions of many drugs.
Food-drug interactions occur on a daily basis and are of great clinical importance when they affect the total amount of drugs absorbed. The adverse consequences of the interaction between grapefruit juice and drugs have attracted everyone's attention, and pharmacists need to drink grapefruit juice carefully when taking relevant drugs when explaining the medication to patients. In addition, patients should also carefully consider the interaction between food and drugs when taking drugs, and carefully ask doctors and pharmacists before taking drugs to avoid similar serious adverse events.
[Editor-in-charge: Wu Daixia]
[Source: Sanxiang Metropolis Daily]